Results 11 to 20 of about 95,123 (282)
International Journal of Biological Sciences, 2021 Breast cancer susceptibility gene 1 (BRCA1) encodes a tumor suppressor that is frequently mutated in familial breast and ovarian cancer patients. BRCA1 functions in multiple important cellular processes including DNA damage repair, cell cycle checkpoint activation, protein ubiquitination, chromatin remodeling, transcriptional regulation, as well as R ...
Yang, Jing +5 more
openaire +2 more sources
Current Biology, 2000 Bertwistle D, Ashworth A: Functions of the BRCA1 and BRCA2 genes.Curr Opin Genet Dev 1998, 8:14-20.Rahman N, Stratton MR: The genetics of breast cancer susceptibility.Annu Rev Genet 1998, 32:95-121.Hongbing Z, Tombline G, Weber BL: BRCA1, BRCA2, and DNA damage response: collision or collusion?Cell 1998, 92:433-436.
Bertwistle, David, Ashworth, Alan
openaire +2 more sources
A systematic review on the association between ovarian and prostate cancer with BRCA1 and BRCA2 gene
Сибирский онкологический журнал, 2023 Background. BRCA1 and BRCA2 were discussed as the basis of inherited adenocarcinoma and breast and ovarian malignancy. Ovarian cancer is uncommon in women below 40 years of age, and prostate cancer mainly occurs in older men cause 90 % in those above ...
Sarpparajan Chitra Veena +2 more
doaj +1 more source
Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1 [PDF]
Oncogene, 2001 Unregulated expression of wild-type BRCA1 (wtBRCA1) confers an altered phenotype in cultured human prostate cancer cells, characterized by chemosensitivity, susceptibility to apoptosis, decreased DNA repair activity, and alterations of key cell regulatory proteins.
S, Fan +5 more
openaire +2 more sources
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2022 Введение. Овариальные карциномы – сложное гетерогенное заболевание с разнообразием клинико-морфологических форм. В большинстве случаев опухоли яичников экспрессируют эстрогеновые (РЭ), прогестероновые (РП) или андрогеновые (РА) рецепторы, но, в отличие ...
А. L. Savаnevich +2 more
doaj +1 more source
BRCA1-BARD1: the importance of being in shape
Molecular & Cellular Oncology, 2019 The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation.
Manuel Daza-Martin +2 more
doaj +1 more source
BRCA1 16 years later: DNA damage‐induced BRCA1 shuttling [PDF]
The FEBS Journal, 2010 The tumor suppressor, breast cancer susceptibility gene 1 (BRCA1), plays an integral role in the maintenance of genome stability and, in particular, the cellular response to DNA damage. Here, the emerging role of BRCA1 in nonhomologous end‐joining‐mediated DNA repair following DNA damage will be reviewed, as well as the activation of apoptotic pathways.
Eddy S, Yang, Fen, Xia
openaire +2 more sources
The prognostic significance of BRCA1 gene expression in patients with breast cancer
Успехи молекулярной онкологии, 2019 Background. Nowadays, BRCA-associated breast cancer occupies a special position in the choice of treatment strategy. Although, the drug treatment of such patients was almost the same as the treatment of sporadic disease.
M. M. Tsyganov +5 more
doaj +1 more source
Hereditary breast cancer: genetic and clinical hetergeneity, genetic testing, prophylactic surgery
Успехи молекулярной онкологии, 2015 5–10 % of breast cancer cases are hereditary, 30 % of them are caused by BRCA1 and BRCA2 mutations (breast / ovarian cancer syndrome). Average cumulative risks of breast and ovarian cancer in BRCA1 mutation carriers run up to 87 % and 44 ...
L. N. Lyubchenko +8 more
doaj +1 more source
Успехи молекулярной онкологии, 2018 Background. Most modern studies are limited to the study of only germline mutations of the BRCA1 gene (most often 5382insC). And there are very few works that characterize the different somatic changes in the BRCA1 gene in the tumor, in particular the ...
M. M. Tsyganov +6 more
doaj +1 more source