A systematic review on the association between ovarian and prostate cancer with BRCA1 and BRCA2 gene
Сибирский онкологический журнал, 2023 Background. BRCA1 and BRCA2 were discussed as the basis of inherited adenocarcinoma and breast and ovarian malignancy. Ovarian cancer is uncommon in women below 40 years of age, and prostate cancer mainly occurs in older men cause 90 % in those above ...
Sarpparajan Chitra Veena +2 more
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Mutations in pathways depending on BRCA1 and BRCA2 may increase cancer risks from an environmental carcinogen [PDF]
, 2011 Recently, the President’s Cancer Panel [2008-2009] protested that preventive action is not taken when uncertainty exists about potential harm from a chemical, because the US regulatory approach demands that a hazard be incontrovertibly ...
Bernard Friedenson
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Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2022 Введение. Овариальные карциномы – сложное гетерогенное заболевание с разнообразием клинико-морфологических форм. В большинстве случаев опухоли яичников экспрессируют эстрогеновые (РЭ), прогестероновые (РП) или андрогеновые (РА) рецепторы, но, в отличие ...
А. L. Savаnevich +2 more
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DNA methylation profiling to assess pathogenicity of BRCA1 unclassified variants in breast cancer [PDF]
, 2015 Germline pathogenic mutations in BRCA1 increase risk of developing breast cancer. Screening for mutations in BRCA1 frequently identifies sequence variants of unknown pathogenicity and recent work has aimed to develop methods for determining pathogenicity.
AFFECT +10 more
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BRCA1/2 associated cancer susceptibility: a clinical overview
Forum of Clinical Oncology, 2016 The most frequently identified genetic cause of breast cancer is the germline mutation of BRCA1 and 2 genes. The carriers of these mutations are at high risk for breast and ovarian cancers and increased risk for pancreatic and prostate cancers.
Lypas Georgios
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Developing a community-based breast cancer risk prediction tool for resource-poor settings
Journal of Education and Health Promotion, 2019 BACKGROUND: With an estimation of every two women newly diagnosed with breast cancer, one dies. It is accounted that 1 in 28 women is likely to develop breast cancer during her lifetime.
Divya Pillai +2 more
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RE: Universal tumor DNA BRCA1/2 testing of ovarian cancer: prescreening PARPi treatment and genetic predisposition [PDF]
, 2019 BRCA1/2 mutations play a predictive role in ovarian cancer risk evaluation. Moreover , patients are today being tested for BRCA1/2 mutations to select a tailored therapy too , because they could benefit from a treatment with PARP inhibitors (PARPi ...
Panici, Pierluigi Benedetti +2 more
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PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks [PDF]
, 2020 Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating DNA damage ...
Alonso de la Vega, Ignacio +9 more
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BRCA1 A-Complex fine tunes repair functions of BRCA1
Aging, 2011 Germline mutations in BRCA1 increase the risk of breast and ovarian cancer, but the specific pathways driving breast and ovarian cancer development in BRCA1 mutants are currently unclear [1]. Several studies have demonstrated that BRCA1 is required for cellular responses to DNA double strand breaks (DSBs) and homologous recombination (HR), although its
Janelle L, Harris, Kum Kum, Khanna
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Contribution of MUTYH variants to male breast cancer risk: results from a multicenter study in Italy [PDF]
, 2018 Inherited mutations in BRCA1, and, mainly, BRCA2 genes are associated with increased risk of male breast cancer (MBC). Mutations in PALB2 and CHEK2 genes may also increase MBC risk.
Azzollini, Jacopo +25 more
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