Results 81 to 90 of about 158,234 (188)

Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase

Cells, 2020
DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear.
Zhongliang Jiang, Yanhao Lai, Jill M. Beaver, Pawlos S. Tsegay, Ming-Lang Zhao, Julie K. Horton, Marco Zamora, Hayley L. Rein, Frank Miralles, Mohammad Shaver, Joshua D. Hutcheson, Irina Agoulnik, Samuel H. Wilson, Yuan Liu   +13 more
doaj   +1 more source

BRCA1 and Oxidative Stress [PDF]

Cancers, 2014
The breast cancer susceptibility gene 1 (BRCA1) has been well established as a tumor suppressor and functions primarily by maintaining genome integrity. Genome stability is compromised when cells are exposed to oxidative stress. Increasing evidence suggests that BRCA1 regulates oxidative stress and this may be another mechanism in preventing ...
Yi, Yong Weon, Kang, Hyo Jin, Bae, Insoo
openaire   +2 more sources

Niraparib in ovarian cancer. results to date and clinical potential [PDF]

, 2017
Ovarian cancer is the first cause of death from gynaecological malignancy. Germline mutation in BRCA1 and 2, two genes involved in the mechanisms of reparation of DNA damage, are showed to be related with the incidence of breast and ovarian cancer, both ...
Benedetti Panici, Pierluigi, Caruso, Davide, Papa, Anselmo, Tomao, Federica, Tomao, Silverio, Vici, Patrizia   +5 more
core   +1 more source

Bayesian assessment of the prevalence of BRCA-associated breast cancer in Moscow

Alʹmanah Kliničeskoj Mediciny, 2020
Rationale: For many years, breast cancer has been leading in the cancer structure in women, accounting for 21% from the total number of newly diagnosed cases of malignancies in Russia. The literature on the prevalence of the BRCA-associated breast cancer
A. V. Viskovatykh
doaj   +1 more source

Exposure to nanographene oxide induces gene expression dysregulation in normal human astrocytes

Endocrine Regulations, 2022
Objective. Nanographene oxide, an oxidation derivative of graphene, is considered to be one of the nanomaterials attractive for biomedical applications, although this nanomaterial is toxic.
Rudnytska Olha V., Kulish Yuliia V., Khita Olena O., Minchenko Dmytro O., Tsymbal Dariia O., Viletska Yuliia M., Sliusar Myroslava Y., Trufanova Dariia D., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

Population testing for cancer predisposing BRCA1/BRCA2 mutations [PDF]

, 2014
Background: Technological advances raise the possibility of systematic population-based genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits outweigh disadvantages.
Wardle, J
core  

PARP inhibition: a promising therapeutic target in ovarian cancer [PDF]

, 2015
Ovarian cancer is burdened by the highest mortality rate among gynecological cancers. Gold standard is represented by the association of platinum-taxane -based chemotherapy and radical surgery.
Abdul Halim, T, BENEDETTI PANICI, PIERLUIGI, CASORELLI, ASSUNTA, DI DONATO, VIOLANTE, DOMENICI, LAVINIA, GASPARRI, MARIALUISA, IMPERIALE, LUDOVICA, MARCHETTI, CLAUDIA, MONTI, Marco, MUSELLA, ANGELA, MUZII, LUDOVICO, PALAIA, INNOCENZA, PECORINI, Francesco, RUSCITO, ILARY, SALERNO, LAURA   +14 more
core   +1 more source

RESPONSE TO NEOADYAVANT CHEMOTHERAPY WITH PLATINUM-BASED DRUGS IN BREAST CANCER PATIENTS WITH BRCA1 DELETION IN TUMOR

Сибирский онкологический журнал, 2019
Currently, the presence of the germinal mutation BRCA1 5382insC in breast cancer patients is one of the determining factors for prescribing platinum-based drugs.
M. M. Tsyganov, N. A. Tarabanovskaya, I. V. Deryusheva, M. K. Ibragimova, P. V. Kazantseva, A. M. Pevzner, E. M. Slonimskaya, N. V. Litviakov   +7 more
doaj   +1 more source

Factors Influencing Uptake of Risk-Reducing Salpingo-Oophorectomy by BRCA1 and BRCA2 Mutation Carriers [PDF]

, 2016
Germline mutations in the BRCA1 and BRCA2 genes are associated with significantly increased risks for ovarian cancer. The National Comprehensive Cancer Network (NCCN) currently recommends that female BRCA mutation carriers undergo risk-reducing salpingo ...
Breen, Victoria E
core   +1 more source

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers [PDF]

, 2014
Peer reviewedPublisher ...
Andrulis, Irene L, Arun, Banu K, Barrowdale, Daniel, Benitez, Javier, Breast Cancer Family Registry, Buys, Saundra S, Cass, Ilana, Cunningham, Julie, Daly, Mary B, Dennis, Joe, Domchek, Susan M, Dorfling, Cecilia M, Duran, Mercedes, Ejlertsen, Bent, Engel, Christoph, Gerdes, Anne-Marie, Goldgar, David E, Hart, Steven, Healey, Sue, James, Paul, Janavicius, Ramunas, Karlan, Beth Y, Kuchenbaecker, Karoline B, Lee, Andrew, Lester, Jenny, McGuffog, Lesley, Miedzybrodzka, Zofia Helena, Mulligan, Anna Marie, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nielsen, Finn C, Nussbaum, Robert L, Osorio, Ana, Radice, Paolo, Ramus, Susan J, Rebbeck, Timothy R, Robson, Mark, Schmidt, Marjanka K, Schmutzler, Rita K, Slager, Susan, Southey, Melissa, Spurdle, Amanda B, Steele, Linda, Terry, Mary Beth, Thomassen, Mads, Tihomirova, Laima, Tung, Nadine, v O Hansen, Thomas, van Rensburg, Elizabeth J, Wappenschmidt, Barbara   +50 more
core   +3 more sources