Results 81 to 90 of about 95,123 (282)

Цитогенетические повреждения и эпигенетический статус промоторов генов TP53, BRCA1 и ERCC2 у работников угольных предприятий [PDF]

Письма в Вавиловский журнал генетики и селекции
Человек подвергается воздействию различных химических соединений на протяжении жизни, однако профессиональная специализация обуславливает наиболее опасное воздействие на организм. Важной проблемой является понимание влияния промышленной среды на геномную
Марущак А.В, Астафьева М.В, Глушков А.Н., Минина В.И.   +3 more
doaj   +1 more source

BRCA1 testing [PDF]

Hereditary Cancer in Clinical Practice, 2008
Górski Bohdan, Lubiński Jan
openaire   +3 more sources

Pearl‐Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair

Advanced Science, EarlyView.
In this study, inspired by pearl architecture, we developed a layered Ca–P “brick” and Fn‐mimetic peptide “mortar” coating on Mg alloys. The Ca–P layer moderates corrosion and offers mineral cues, while the peptide enhances adhesion and regulates immune‐vascular responses.
Siming Zhang, Tao Zhang, Yuan Chen, Nikolaos Kourkoumelis, Mo Chen, Jiale Dong, Zhenyu Li, Yanling Zhou, Ning Li, Chen Zhu, Xifu Shang, Jiaxiang Bai, Xianzuo Zhang   +12 more
wiley   +1 more source

?????? ??????????????: ???????????????? ?????????????? ?????????????? ???? ???????????????? ???????????????? ???????????????????? ?????????????? ?? ?????????? BRCA1 ???? BRCA2 [PDF]

, 2019
?? ???????????? ???????????????????????????? ???????? ???????????????????? ?? ???????????????????? ?????????????? ???????????????????? ???????????????? ???????? ?????????????? (????) ???? ??????????????, ???? ?????????????????????? ?? ?????????????????? ?? ??????????-???????????????????? ???????????????????? ?????????? BRCA1/2, ?? ???? ?????????????????
openaire   +3 more sources

Carrier screening program for BRCA1/BRCA2 pathogenic variants among Ashkenazi Jewish women in Israel: An observational study

, 2023
Rotem Greenberg, Efrat Aharonov‐Majar, Ofer Isakov, Samah Hayek, Naama Elefant, Ran D. Balicer, Adi Berliner Senderey, Shay Ben‐Shachar   +7 more
openalex   +1 more source

Phagocytic Mesothelial Cells in Pericardial Effusion Following Allogeneic Peripheral Blood Stem Cell Transplantation for Chronic Active Epstein–Barr Virus Infection: A Distinctive Cytomorphological and Immunocytochemical Case Study

Diagnostic Cytopathology, EarlyView.
ABSTRACT Phagocytic activity of mesothelial cells is a rare phenomenon requiring careful differentiation from histiocytic hemophagocytosis to ensure appropriate patient management, as these phenomena could exhibit distinct clinical implications. In this study, we report a case of phagocytic mesothelial cells found in pericardial effusion that developed
Hidetoshi Satomi, Ayumi Ryu, Sei Murayama, Hiroya Kojima, Satoshi Tanada, Keiichiro Honma   +5 more
wiley   +1 more source

Screening of BRCA1 variants c.190T>C, 1307delT, g.5331G>A and c.2612C>T in breast cancer patients from North India

Genetics and Molecular Biology
The polymorphic variants of BRCA1, which lead to amino acid substitutions, have a known pathogenic role in breast cancer. The present study investigated in North Indian breast cancer patients the association of risk with four reported pathogenic variants
Akeen Kour, Vasudha Sambyal, Kamlesh Guleria, Neeti Rajan Singh, Manjit Singh Uppal, Mridu Manjari, Meena Sudan   +6 more
doaj   +1 more source

Novel associations between BRCA1 variants c.181 t>g (rs28897672) and ovarian cancer risk in Saudi females [PDF]

Journal of Medical Biochemistry, 2019
Background: Mutations in BRCA1 gene have been implicated in ovarian cancers, and BRCA testing may be conducted in high-risk women. This study was designed to determine the frequency of three single nucleotide polymorphisms (SNPs) variants in BRCA1 gene ...
Alyahr Nora, Abdi Saba, Khan Wajahatullah, Elrobh Mohamed, Addar Mohammed H., Babay Zeneb A., Alanaz Mohamed, Aldaihan Sooad, Shaik Jilani, Arafah Maha, Reddy-Parine Narasimha, Warsy Arjumand   +11 more
doaj  

Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study

Programme Grants for Applied Research, 2016
Background: In the UK, women are invited for 3-yearly mammography screening, through the NHS Breast Screening Programme (NHSBSP), from the ages of 47–50 years to the ages of 69–73 years.
D Gareth Evans, Susan Astley, Paula Stavrinos, Elaine Harkness, Louise S Donnelly, Sarah Dawe, Ian Jacob, Michelle Harvie, Jack Cuzick, Adam Brentnall, Mary Wilson, Fiona Harrison, Katherine Payne, Anthony Howell   +13 more
doaj   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source