Clinicopathological Characteristics of Patients with BRCA Mutation Breast Cancer in North Sumatera: Case Report [PDF]
Middle East Journal of Cancer, 2023 The most common cancer in women is breast cancer (BC) with an incidence of 24.2%. BC in younger patients will in general be more forceful, prompting more awful results and a requirement for more forceful treatment which may bring about a higher ...
Dedy Hermansyah +3 more
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Hereditary breast cancer and ovarian cancer: clinical course and treatment
Опухоли женской репродуктивной системы, 2021 This article analyzes current problems associated with surgical and systemic treatment for hereditary breast and ovarian cancers (including those associated with BRCA1/2 gene mutations).
V. V. Semiglazov +2 more
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A systematic review on the association between ovarian and prostate cancer with BRCA1 and BRCA2 gene
Сибирский онкологический журнал, 2023 Background. BRCA1 and BRCA2 were discussed as the basis of inherited adenocarcinoma and breast and ovarian malignancy. Ovarian cancer is uncommon in women below 40 years of age, and prostate cancer mainly occurs in older men cause 90 % in those above ...
Sarpparajan Chitra Veena +2 more
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A Case of Triple-Negative Breast Cancer with Germline Pathogenic Variants in Both BRCA1 and BRCA2
Case Reports in Oncology, 2021 We report a rare case of hereditary breast and ovarian cancer syndrome (HBOC) with pathogenic variants in both BRCA1 and BRCA2. The patient was a 78-year-old woman who visited the hospital after noticing a lump in her left breast 6 months before, which ...
Miyuki Kitahara +3 more
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Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) [PDF]
, 2009 Background: In this study we aimed to evaluate the role of a SNP in intron 1 of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and ...
A Allavena +151 more
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Cells, 2020 Research on repurposing the old alcohol-aversion drug disulfiram (DSF) for cancer treatment has identified inhibition of NPL4, an adaptor of the p97/VCP segregase essential for turnover of proteins involved in multiple pathways, as an unsuspected cancer ...
Dusana Majera +5 more
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Bayesian assessment of the prevalence of BRCA-associated breast cancer in Moscow
Alʹmanah Kliničeskoj Mediciny, 2020 Rationale: For many years, breast cancer has been leading in the cancer structure in women, accounting for 21% from the total number of newly diagnosed cases of malignancies in Russia. The literature on the prevalence of the BRCA-associated breast cancer
A. V. Viskovatykh
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Case Reports in Gastroenterology, 2022 Smoking is a known risk factor for the development of colorectal polyps. Even in familial adenomatous polyposis and serrated polyposis syndrome, smoking is a risk factor of the development of polyps.
Naohisa Yoshida +10 more
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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
Molecular & Cellular Oncology, 2021 In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair ...
Belen Gómez-González +3 more
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Diagnosis and treatment of ovarian cancer in the light of modern molecular genetic achievements
Сибирский онкологический журнал, 2023 The purpose of the study was to systematize and summarize the literature data on the study of clinical and genetic aspects, molecular pathogenesis, as well as new trends in the diagnosis and treatment of ovarian cancer.Material and Methods.
E. M. Kagirova +2 more
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