Results 11 to 20 of about 45,831 (210)
Pleura and Peritoneum, 2023 The aim of this study is to analyze the prevalence of somatic mutations in BRCA1 and BRCA2 in malignant mesothelioma and their putative impact on protein properties.
Krishnamurthy Kritika +4 more
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Case Reports in Gastroenterology, 2022 Smoking is a known risk factor for the development of colorectal polyps. Even in familial adenomatous polyposis and serrated polyposis syndrome, smoking is a risk factor of the development of polyps.
Naohisa Yoshida +10 more
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Diagnosis and treatment of ovarian cancer in the light of modern molecular genetic achievements
Сибирский онкологический журнал, 2023 The purpose of the study was to systematize and summarize the literature data on the study of clinical and genetic aspects, molecular pathogenesis, as well as new trends in the diagnosis and treatment of ovarian cancer.Material and Methods.
E. M. Kagirova +2 more
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Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2 -Mutated Ovarian Carcinoma [PDF]
Cancer Research, 2009 Abstract Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas. However, the mechanism of the drug resistance has not been elucidated. Here, we show functional significance of restoration of BRCA2 protein by secondary BRCA2 mutations in acquired drug resistance of BRCA2-mutated ovarian carcinoma ...
Sakai, Wataru +9 more
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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
Molecular & Cellular Oncology, 2021 In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair ...
Belen Gómez-González +3 more
doaj +1 more source
BRCA1 and BRCA2 and Inherited Predisposition to Breast and Ovarian Cancers
McGill Journal of Medicine, 2002 N ...
Patricia N. Tonin
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Case Reports in Oncology, 2020 DNA repair mutations (BRCA1 and BRCA2) are found in metastatic castration-resistant prostate cancer (CRPC) patients. Here, we report a case of a 71-year-old male patient with metastatic CRPC along with BRCA2 and PTEN mutations.
Pramod Kumar Julka +2 more
doaj +1 more source
Clinical consequences of BRCA2 hypomorphism [PDF]
npj Breast Cancer, 2021 AbstractThe tumor suppressor FANCD1/BRCA2 is crucial for DNA homologous recombination repair (HRR). BRCA2 biallelic pathogenic variants result in a severe form of Fanconi anemia (FA) syndrome, whereas monoallelic pathogenic variants cause mainly hereditary breast and ovarian cancer predisposition.
Laia Castells-Roca +17 more
openaire +6 more sources
Guideline-Based, Multi-Gene Panel Germline Genetic Testing for at-Risk Patients with Breast Cancer
Breast Cancer: Targets and Therapy, 2023 Hikmat Abdel-Razeq,1,2 Lama Abujamous,3 Khansa Al-Azzam,1 Hala Abu-Fares,1 Hira Bani Hani,1 Mais Alkyam,1 Baha’ Sharaf,1 Shatha Elemian,1 Faris Tamimi,1 Fawzi Abuhijla,4 Sarah Edaily,1 Osama Salama,1 Hazem Abdulelah,1 Rand Daoud,1 Mohammad Abubaker,1 ...
Abdel-Razeq H +15 more
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BRCA2 Haploinsufficiency in Telomere Maintenance [PDF]
Genes, 2021 Our previous studies showed an association between monoallelic BRCA2 germline mutations and dysfunctional telomeres in epithelial mammary cell lines and increased risk of breast cancer diagnosis for women with BRCA2 999del5 germline mutation and short telomeres in blood cells.
Soffía R. Gunnarsdottir +6 more
openaire +2 more sources