Results 11 to 20 of about 104,745 (290)
BRCA2 in mammalian meiosis [PDF]
Trends in Cell Biology, 2022 Breast cancer type 2 susceptibility protein (BRCA2) is a central regulator of homologous recombination in somatic cells and safeguards genomic integrity against DNA double-strand breaks (DSBs). Recent evidence suggests that association with unique meiosis-specific cofactors allows BRCA2 to facilitate homologous recombination in germ cells.
Zhang, Jingjing +2 more
openaire +2 more sources
Current Biology, 2000 Bertwistle D, Ashworth A: Functions of the BRCA1 and BRCA2 genes.Curr Opin Genet Dev 1998, 8:14-20.Rahman N, Stratton MR: The genetics of breast cancer susceptibility.Annu Rev Genet 1998, 32:95-121.Hongbing Z, Tombline G, Weber BL: BRCA1, BRCA2, and DNA damage response: collision or collusion?Cell 1998, 92:433-436.
Bertwistle, David, Ashworth, Alan
openaire +2 more sources
Role of Single Nucleotide Polymorphisms in BRCA1 and BRCA2 Genes Relative to Previous Studies in Pakistan in the Prognosis of Breast Cancer [PDF]
Journal of Liaquat National HospitalBreast cancer is a complex disease characterized by a myriad of genetic alterations. Single nucleotide polymorphisms are particularly relevant due to small allelic variations.
Saba Munir +6 more
doaj +1 more source
Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells [PDF]
, 2011 This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Sapir et al.Background: Recent studies suggest that BRCA2 affects telomere maintenance.
Al-Wahiby, S +5 more
core +3 more sources
Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2 -Mutated Ovarian Carcinoma [PDF]
Cancer Research, 2009 Abstract Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas. However, the mechanism of the drug resistance has not been elucidated. Here, we show functional significance of restoration of BRCA2 protein by secondary BRCA2 mutations in acquired drug resistance of BRCA2-mutated ovarian carcinoma ...
Sakai, Wataru +9 more
openaire +3 more sources
Опухоли женской репродуктивной системы, 2015 Background. The early diagnosis of ovarian cancer (OC) is an important problem in modern gynecological oncology due to significant detection rates for late-stage tumors. Intensive screening of patients from high-risk groups that include OC predisposition
Ye. I. Bateneva +10 more
doaj +1 more source
Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum. [PDF]
, 2012 In most organisms, the primary function of homologous recombination (HR) is to allow genome protection by the faithful repair of DNA double-strand breaks.
Buisson, Rémi +9 more
core +2 more sources
Опухоли женской репродуктивной системы, 2014 Screening of breast cancer with mammography recommended to women over 40 has been shown to decrease breast cancer mortality. But mam- mography has much lower accuracy in young women with BRCA1/2 mutations and women with a strong family history. Therefore
M. S. Karpova +4 more
doaj +1 more source
Case Reports in Oncology, 2020 DNA repair mutations (BRCA1 and BRCA2) are found in metastatic castration-resistant prostate cancer (CRPC) patients. Here, we report a case of a 71-year-old male patient with metastatic CRPC along with BRCA2 and PTEN mutations.
Pramod Kumar Julka +2 more
doaj +1 more source
Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients. [PDF]
, 2017 PurposeMany women with an elevated risk of hereditary breast and ovarian cancer have previously tested negative for pathogenic mutations in BRCA1 and BRCA2. Among them, a subset has hereditary susceptibility to cancer and requires further testing.
Adams, Sophie B +8 more
core +1 more source