Results 101 to 110 of about 3,728 (186)

Time-resolved transcriptome analysis of TH-MYCN driven hyperplastic ganglia and tumors marks BRD3 as a novel candidate oncogene

, 2014
Time-resolved transcriptome analysis of a transgenic mouse model has been shown useful to study the molecular events associated with tumor progression, and to identify novel therapeutic candidates.
Carter, Daniel, Vandesompele, Jo, Marshall, Glen, Speleman, Franki, De Preter, Katleen, Beckers, Anneleen, Belamy, Cheung   +6 more
core  

Supplementary Figure S1 from The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects

, 2016
The BET bromodomain proteins BRD3 and BRD4 induce N-Myc expression, but do not function synergistically.
Pei Y. Liu (14896544), Bernard Atmadibrata (524472), Richard B. Lock (12588187), Tao Liu (10785), Glenn M. Marshall (9902807), Jeyran Shahbazi (14998872), James E. Bradner (513974)   +6 more
core   +1 more source

Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

Cells
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, associated with poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular mechanism of the origin and development of uLMS is limited. Bromodomain and extra-
Qiwei Yang, Ali Falahati, Azad Khosh, Ricardo R. Lastra, Thomas G. Boyer, Ayman Al-Hendy   +5 more
doaj   +1 more source

Additional file 1: of FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma

, 2018
Figure S1. BRD2, BRD3 or BRD4 make no effect on the expression of FBP1. Table S2. Sequences for shRNAs.
Bo Wang (86769), Xin Jin (108988), Heshui Wu (734481), Heyu Wu (5735504), Ping Fan (378817), Jingyuan Zhao (811333)   +5 more
core   +1 more source

Interactome rewiring following pharmacological targeting of BET bromodomains

, 2018
U-2 OS cells were seeded onto 8-well LabTek II imaging chambers (ThermoFisher) in complete media with 1 μg/mL tetracycline and grown for 24 h to allow expression of GFP-tagged protein. Before imaging, the media was replaced with 200 μL of phenol red-free
Lambert, J (via Mendeley Data)
core   +1 more source

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts.

, 2014
OBJECTIVE: To investigate the effects of BET bromodomain protein inhibition on inflammatory activation and functional properties of rheumatoid arthritis synovial fibroblasts (RASF).
Prinjha, Rab K, Reedquist, Kris A, Kolling, Christoph, Ospelt, Caroline, Klein, Kerstin, Grabiec, Aleksander M, Kabala, Pawel A, Gay, Steffen, Gay, Renate E, Lin, Lih-Ling, Tak, Paul P   +10 more
core   +1 more source

Aggressive PTH-secreting lung carcinoma with a BRD3: NUTM1 fusion presenting with refractory hypercalcemia

Journal of Case Reports and Images in Oncology
Introduction: Nuclear protein in testis (NUT) midline carcinomas (NMCs) are rare and aggressive cancers. These carcinomas are defined by gene re-arrangement leading to fusion of the NUT gene on chromosome 15 with other genes. These are named as such as they are solid tumors most frequently occurring in the midline including lung, central ...
Spyridon Gennatas, Alexandros Georgiou, Thomas Simpson, Emma Mclean, Keziah Abbotts, Rosa Evans   +5 more
openaire   +1 more source

The role of GATA1 acetylation during erythroid development

, 2011
Post-translational modifications such as acetylation and phosphorylation play key roles in controlling protein function. The hematopoietic transcription factor GATA1 is acetylated at several lysine residues near its zinc finger domains. To understand the
Lamonica, Janine M
core  

Thermodynamic analysis of acetylation-dependent Pb1 bromodomain-histone H3 interactions

, 2008
An acetyl-histone peptide library was used to determine the thermodynamic parameters that define acetylation-dependent bromodomain-histone interactions. Bromodomains interact with histones by binding acetylated lysines. The bromodomain used in this study,
Chandrasekaran, Renu, Thompson, Martin
core   +1 more source

Bromodomain containing 4 (BRD4); BRD2; BRD3 [PDF]

Science-Business eXchange, 2014
openaire   +1 more source