Results 81 to 90 of about 3,728 (186)

Polymorphism of pfmdr1 Gene Mutation Conferring Resistance to Artemisinin‐Based Combination Therapy in Plasmodium falciparum in Patients at Gulu Regional Referral Hospital in Northern Uganda

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Background Malaria is one of the most devastating infectious diseases in humans, and antimalarial drugs have been used to combat it with minimal success. Worldwide, malaria treatment is threatened by the emergence and spread of artemisinin resistance, which is associated with mutations in the PfK13 propeller domain. In Sub‐saharan Africa, data relating
Florence Peace Amito, Harriet Angwech, Lonzy Ojok, Godfrey Wokorach, Stephen Ochaya, Quinto Ogwang, Robert Opiro, Richard Echodu, Satabdi Datta Choudhury   +8 more
wiley   +1 more source

AF-CBA results for BRD3:MLVIN-TP

<p>This tarball has all the inputs, setup files, analysis scripts, and results for reproducing the AF-CBA pipeline for the BRD3:MLVIN complex. For more details, please go through our AF-CBA paper https://doi.org/10.1101/2024.01.20.576374. </
Mondal, Arup
core   +1 more source

Three calcium-sensitive genes, fus, brd3 and wdr5, are highly expressed in neural and renal territories during amphibian development

, 2013
Numerous Ca2+ signaling events have been associated with early development of vertebrate embryo, from fertilization to organogenesis. In Xenopus laevis, Ca2+ signals are key regulators in the earliest steps of the nervous system development.
Néant, I., Bibonne, A., Moreau, M., Leclerc, C., Batut, J., Gilbert, T.   +5 more
core   +1 more source

Overcoming BET‐inhibitor JQ1 resistance in aggressive non‐small cell lung cancer by inducing ferroptosis via inhibition of the BRD2–FTH1 axis

The FEBS Journal, Volume 292, Issue 23, Page 6345-6364, December 2025.
Recent studies emphasize alternative functions of FTH1 relevant for nuclear processes, such as transcriptional regulation. This study shows a novel FTH1/BRD2 association in non‐small cell lung carcinoma (NSCLC). This nuclear interaction affects BRD2 protein stability in aggressive NSCLC cells.
Stefania Scicchitano, Cinzia Garofalo, Beatrice Stella, Gianluca Santamaria, Flora Cozzolino, Vittoria Monaco, Flavia Biamonte, Maria Monti, Eleonora Vecchio, Maria Concetta Faniello   +9 more
wiley   +1 more source

Analysis of Patterns of Gene Expression Variation within and between Ethnic Populations in Pediatric B-ALL

Cancer Informatics, 2013
B-Precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Although 80% of B-ALL patients are able to be cured, significant challenges persist.
Chindo Hicks, Lucio Miele, Tejaswi Koganti, LaFarra Young-Gaylor, Deidre Rogers, Vani Vijayakumar, Gail Megason   +6 more
doaj   +1 more source

SP3 and DEP1 Orchestrate Panicle Architecture by Jointly Regulating APO2 Expression in Rice

Advanced Science, Volume 12, Issue 44, November 27, 2025.
The transcription factor SP3 enhances inflorescence meristem activity and interacts with the cysteine‐rich domain of DEP1. This interaction alters DEP1's subcellular localization between the plasma membrane and nucleus, and suppresses SP3‐mediated transcriptional activation of APO2.
Yuexin Liu, Niannian Chen, Xiaowei Fan, Xueqing Xia, Yilong Yao, Wen Huang, Jin Sun, Lintao Huang, Lei Wang, Hong Yu, Jiayang Li, Yongzhong Xing   +11 more
wiley   +1 more source

The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators

, 2018
Members of the bromodomain and extra-terminal domain (BET) family of proteins (bromodomain-containing (BRD) 2, 3, 4 and T) are widely expressed and highly conserved regulators of gene expression in eukaryotes.
Jason K.K. Low, Wayne M. Patrick, Dorothy C.C. Wai, Taylor N. Szyszka, Wai, Dorothy C., Szyszka, Taylor N., Amy E. Campbell, Ann H. Kwan, Mackay, J. P., Gamsjaeger, R., Cherry Kwong, Gerd A. Blobel, Gamsjaeger, Roland (R16936), Wai, D. C., Campbell, A. E., Lu, Bin, Chalmers, J. N., Low, Jason K., Mackay, Joel P., Patrick, W. M., Chalmers, James N., Bin Lu, Silva, A. P. G., Blobel, Gerd A., Ana P.G. Silva, Blobel, G., Silva, Ana P., Christopher R. Vakoc, Patrick, Wayne N., Vakoc, Christopher R., Vakoc, C. R., Kwan, Ann H., Szyszka, T. N., Low, J. K. K., Lorna E. Wilkinson-White, Campbell, Amy E., Kwan, A. H., Lu, B., Joel P. Mackay, Roland Gamsjaeger, Wilkinson-White, L. E., Wilkinson-White, Lorna, Kwong, Cherry, Kwong, C., James D. Chalmers   +44 more
core   +1 more source

Case report: Diagnosis of NUT carcinoma of hepatic origin by next-generation sequencing

Frontiers in Oncology
NUT carcinoma is a rare subcategory of squamous cell carcinoma. The latter is primarily characterized by the fusion of the coding sequence NUTM1 on chromosome 15q14 with BRD4 or BRD3, both of which are acetyl-histone binding bromodomains.
Bach Ardalan, Jose Azqueta, Jia Luo, Christopher French   +3 more
doaj   +1 more source

Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases

Frontiers in Pharmacology, 2019
Epigenetic mechanisms, especially DNA methylation and histone modifications, are dynamic processes that regulate the gene expression transcriptional program in normal and diseased states. The bromodomain and extraterminal (BET) protein family (BRD2, BRD3,
Jose Luis Morgado-Pascual, Jose Luis Morgado-Pascual, Sandra Rayego-Mateos, Sandra Rayego-Mateos, Lucia Tejedor, Lucia Tejedor, Beatriz Suarez-Alvarez, Beatriz Suarez-Alvarez, Marta Ruiz-Ortega, Marta Ruiz-Ortega   +9 more
doaj   +1 more source

DataSheet_1_Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma.pdf

, 2022
NUT carcinoma (NC) is a rare and extremely aggressive form of cancer, usually presenting with intrathoracic or neck manifestations in adolescents and young adults.
Sebastian Böhm (14016468), Sven Günther (408410), Sandra Mairhofer (14016474), Tina Ganzenmueller (6830906), Stephan Singer (3404138), Simone Haas (14016471), Linus D. Kloker (9091764), Susanne Berchtold (152851), Mary E. Carter (11870858), Branko Calukovic (14016459), Niels Reinmuth (4471012), Thomas Duell (6985016), Julia Beil (9091767), Robert Stöhr (3583700), Katrin Benzler (14016462), Marius Horger (848053), Ulrich M. Lauer (8746293), Alexander Golf (14016465), Lars Zender (698425), Abbas Agaimy (395011), Arndt Hartmann (42756), Fabian Fohrer (14016477)   +21 more
core   +1 more source