Results 61 to 70 of about 3,728 (186)
The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation
Advanced Science, Volume 13, Issue 17, 23 March 2026.ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley +1 more source
Cell Reports, 2013 A hallmark of retroviral replication is integration of the viral genome into host cell DNA. This characteristic makes retrovirus-based vectors attractive delivery vehicles for gene therapy.
Jan De Rijck +11 more
doaj +1 more source
Advanced Science, Volume 13, Issue 7, 3 February 2026.MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li +10 more
wiley +1 more source
Scientific Reports, 2017 The heat shock response is characterized by the transcriptional activation of both hsp genes and noncoding and repeated satellite III DNA sequences located at pericentric heterochromatin.
Edwige Col +17 more
doaj +1 more source
WHO classification of skin tumours: key updates in the fifth edition
Histopathology, Volume 88, Issue 3, Page 555-568, February 2026.This review article summarizes the key updates in the 5th edition of the WHO Classification of Skin Tumours. It provides an overview of the major changes and new entities specific to the skin section, covering areas such as epidermal, melanocytic, mesenchymal and other tumours. The 5th edition of the World Health Organization Classification of Tumours (
Gabrielle Goldman‐Lévy +29 more
wiley +1 more source
, 2021 BACKGROUND: Nuclear protein in testis (NUT) carcinoma (NC) is an aggressive type of poorly differentiated carcinoma with a variable degree of squamous differentiation. NC is defined by the presence of BRD-NUT fusion oncogenes, the most common fusion form
Perry, Kyle +5 more
core
ChemBioChem, Volume 27, Issue 1, January 2026.Quantitative proteomics reveal distinct activities of speckle‐type POZ protein (SPOP) cancer mutants. SPOP‐F133L, unlike F102C, retains degradation of NUP153 and TPR, and partially down‐regulates p53 through a Cullin‐RING ligase‐dependent mechanism. Both mutants support targeted protein degradation in engineered cells, highlighting opportunities to ...
Alana G. Caldwell +4 more
wiley +1 more source
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation [PDF]
, 2019 Abstract Gene programs that control differentiation are regulated through the interplay between DNA, RNA, and protein. Cooperation among these fundamental cellular components can occur through highly structured interactions connecting domains formed by specific sequences of nucleotides, ribonucleotides, and/or amino ...
Daneshvar, Kaveh +12 more
openaire +1 more source
Frontiers in OncologyBackgroundNuclear protein in testis (NUT) carcinoma (NC) is a rare, aggressive tumor with a typical NUTM1 gene rearrangement.MethodsHerein, we report a series of 2 cases of sinonasal NC: one in a 16-year-old woman and one in a 37-year-old man ...
Min Chen, Shuang Li, Lili Jiang
doaj +1 more source
Melanoma: Pathogenesis and Targeted Therapy
MedComm, Volume 7, Issue 1, January 2026.The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu +5 more
wiley +1 more source