Results 41 to 50 of about 3,728 (186)

Magnifying Glass on Sinonasal NUT Carcinoma Heterogeneity via Spatial Transcriptomics. [PDF]

Head Neck
ABSTRACT Background Nuclear protein in testis (NUT) carcinomas (NCs) are rare, clinically aggressive tumors with characteristic translocation involving NUTM1 and BRD4 genes. While NCs are generally characterized by undifferentiated basaloid cells with focal/abrupt squamous differentiation, tumoral heterogeneity remains unexplored.
Bell D, Choby G, Afkhami M, Maghami E, Ferrarotto R, Snyderman C, Wang E, Hanna E, Seethala R.   +8 more
europepmc   +2 more sources

BRD2 and BRD3 genes independently evolved RNA structures to control unproductive splicing

NAR Genomics and Bioinformatics, 2023
Abstract The mammalian BRD2 and BRD3 genes encode structurally related proteins from the bromodomain and extraterminal domain (BET) protein family.
Petrova, Marina, Margasyuk, Sergey, Vorobeva, Margarita, Skvortsov, Dmitry, Dontsova, Olga A, Pervouchine, Dmitri D   +5 more
openaire   +2 more sources

Anticancer Effects of I-BET151, an Inhibitor of Bromodomain and Extra-Terminal Domain Proteins

Frontiers in Oncology, 2021
I-BET151 is an inhibitor of bromodomain and extra-terminal domain (BET) proteins that selectively inhibits BET family members (BRD2, BRD3, BRD4, and BRDT).
Jiacheng Lai, Ziqiang Liu, Yulei Zhao, Chengyuan Ma, Haiyan Huang   +4 more
doaj   +1 more source

A Common Binding Motif in the ET Domain of BRD3 Forms Polymorphic Structural Interfaces with Host and Viral Proteins [PDF]

SSRN Electronic Journal, 2020
Summary The extra-terminal (ET) domain of BRD3 is conserved among BET proteins (BRD2, BRD3, BRD4), interacting with multiple host and viral protein-protein networks. Solution NMR structures of complexes formed between BRD3-ET domain with either the 79-residue murine leukemia virus integrase (IN) C-terminal domain (IN
Sriram Aiyer, G.V.T. Swapna, Li-Chung Ma, Gaohua Liu, Jingzhou Hao, Gordon Chalmers, Brian C. Jacobs, Gaetano T. Montelione, Monica J. Roth   +8 more
openaire   +2 more sources

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

Epigenetics & Chromatin, 2019
Background Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding
P. Khoueiry, A. Ward Gahlawat, M. Petretich, A. M. Michon, D. Simola, E. Lam, E. E. Furlong, V. Benes, M. A. Dawson, R. K. Prinjha, G. Drewes, P. Grandi   +11 more
doaj   +1 more source

A Novel BRD Family PROTAC Inhibitor dBET1 Exerts Great Anti-Cancer Effects by Targeting c-MYC in Acute Myeloid Leukemia Cells

Pathology and Oncology Research, 2022
Acute myeloid leukemia (AML) represents an aggressive hematopoietic malignancy with a prognosis inferior to that of other leukemias. Recent targeted therapies offer new opportunities to achieve better treatment outcomes.
Kunlong Zhang, Kunlong Zhang, Li Gao, Jianwei Wang, Xinran Chu, Zimu Zhang, Yongping Zhang, Fang Fang, Yanfang Tao, Xiaolu Li, Yuanyuan Tian, Yuanyuan Tian, Zhiheng Li, Xu Sang, Li Ma, Lihui Lu, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Jian Pan, Shaoyan Hu   +21 more
doaj   +1 more source

Abstract 3931: BRD4, BRD3, NSD3, and ZNF532 fusions in histologies beyond NUT carcinomas: Investigation of a large pan-cancer cohort

, 2023
Background: NUT rearrangements drive NUT carcinomas (NCs), which are rare, poorly differentiated tumors with a survival from diagnosis of ~6-7 months.
Febres-Aldana, Christopher A., Mullaney, Kerry, Iasonos, Alexia, Drilon, Alexander E., Cocco, Emiliano, Nykaza, Ian R., Murciano-Goroff, Yonina R., Lin, Sabrina T., Benayed, Ryma, Ladanyi, Marc   +9 more
core   +1 more source

BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes

Cancer Cell International, 2021
Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a high risk of induction failure and poor outcomes, with relapse due to drug resistance.
Shuiyan Wu, You Jiang, Yi Hong, Xinran Chu, Zimu Zhang, Yanfang Tao, Ziwei Fan, Zhenjiang Bai, Xiaolu Li, Yanling Chen, Zhiheng Li, Xin Ding, Haitao Lv, Xiaoli Du, Su Lin Lim, Yongping Zhang, Saihu Huang, Jun Lu, Jian Pan, Shaoyan Hu   +19 more
doaj   +1 more source

Pharmacological Modulation of BET Family in Sepsis

Frontiers in Pharmacology, 2021
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis 3.0) recommended defining sepsis as a life-threatening organ dysfunction caused by the host's uncontrolled response to infection.
Nian Wang, Runliu Wu, Paul B. Comish, Rui Kang, Daolin Tang   +4 more
doaj   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source