Results 21 to 30 of about 3,728 (186)

BRD3 Gene [PDF]

, 2020
openaire   +2 more sources

Discovery of SKP2-Recruiting PROTACs for Target Protein Degradation. [PDF]

Adv Sci (Weinh)
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Dong G, Huang A, Zhao Z, Lai B, Pan X, Yang H, Xu X, Wang T, Zhao F, Zhang Z, Xue Y, Deng G, Deng W, Chen J.   +13 more
europepmc   +2 more sources

Systematic analysis of the BET family in adrenocortical carcinoma: The expression, prognosis, gene regulation network, and regulation targets

Frontiers in Endocrinology, 2023
BackgroundBromodomain and extracellular terminal (BET) family (including BRD2, BRD3, and BRD4) is considered to be a major driver of cancer cell growth and a new target for cancer therapy.
Yongli Situ, Quanyan Liang, Ziying Zeng, Jv Chen, Zheng Shao, Qinying Xu, Xiaoyong Lu, Yongshi Cui, Juying Zhang, Lingling Lu, Li Deng   +10 more
doaj   +1 more source

Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2 [PDF]

Nature Communications
PROTAC® (proteolysis-targeting chimera) molecules induce proximity between an E3 ligase and protein-of-interest (POI) to target the POI for ubiquitin-mediated degradation.
Daniel C. Scott, Suresh Dharuman, Elizabeth Griffith, Sergio C. Chai, Jarrid Ronnebaum, Moeko T. King, Rajendra Tangallapally, Chan Lee, Clifford T. Gee, Lei Yang, Yong Li, Victoria C. Loudon, Ha Won Lee, Jason Ochoada, Darcie J. Miller, Thilina Jayasinghe, Joao A. Paulo, Stephen J. Elledge, J. Wade Harper, Taosheng Chen, Richard E. Lee, Brenda A. Schulman   +21 more
doaj   +2 more sources

BRD3 wt Allele [PDF]

, 2020
openaire   +2 more sources

Epigenetic readers and lung cancer: the rs2427964C>T variant of the bromodomain and extraterminal domain gene BRD3 is associated with poorer survival outcome in NSCLC

Molecular Oncology, 2022
Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate gene expression. We investigated whether variants in BET genes are associated with survival outcomes for lung cancer.
Jang Hyuck Lee, Seung Soo Yoo, Mi Jeong Hong, Jin Eun Choi, Hyo‐Gyoung Kang, Sook Kyung Do, Won Kee Lee, Sun Ha Choi, Yong Hoon Lee, Hyewon Seo, Jaehee Lee, Shin Yup Lee, Seung Ick Cha, Chang Ho Kim, Eung Bae Lee, Sukki Cho, Sanghoon Jheon, Jae Yong Park   +17 more
doaj   +1 more source

Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma

Frontiers in Oncology, 2022
NUT carcinoma (NC) is a rare and extremely aggressive form of cancer, usually presenting with intrathoracic or neck manifestations in adolescents and young adults.
Linus D. Kloker, Branko Calukovic, Katrin Benzler, Alexander Golf, Sebastian Böhm, Sven Günther, Marius Horger, Simone Haas, Simone Haas, Susanne Berchtold, Julia Beil, Julia Beil, Mary E. Carter, Tina Ganzenmueller, Stephan Singer, Abbas Agaimy, Robert Stöhr, Arndt Hartmann, Thomas Duell, Sandra Mairhofer, Fabian Fohrer, Niels Reinmuth, Lars Zender, Lars Zender, Ulrich M. Lauer, Ulrich M. Lauer   +25 more
doaj   +1 more source

Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers [PDF]

Journal of Immunotherapy and Precision Oncology, 2020
The bromodomain and extraterminal (BET) domain protein family is involved in the process of transcription of genetic information. The BET protein family includes BRD2, BRD3, BRD4, and bromodomain testis-specific protein.
Martin V. Nguyen, Lydia Loof, Gerald S. Falchook   +2 more
doaj   +1 more source

Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation

Biomedicines, 2023
BET proteins function as histone code readers of acetylated lysins that determine the positive regulation in transcription of genes involved in cell cycle progression, differentiation, inflammation, and many other pathways. In recent years, thanks to the
Noemi Martella, Daniele Pensabene, Michela Varone, Mayra Colardo, Michele Petraroia, William Sergio, Piergiorgio La Rosa, Sandra Moreno, Marco Segatto   +8 more
doaj   +1 more source

NUT-midline carcinoma of the lung with rare BRD3-NUTM1 fusion

Cancer Research, Statistics, and Treatment
Prerana Jha, Vaishakhi Trivedi, Nandini Menon, Minit Shah, Irene A George, Rohit Mishra, Trupti Pai, Fuzail Ahmad, Venkataramanan Ramachandran, Vanita Noronha, Kumar Prabhash, Prashant Kumar   +11 more
doaj   +2 more sources