Results 11 to 20 of about 3,728 (186)

lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation

Nature Cell Biology, 2020
Cooperation between DNA, RNA and protein regulates gene expression and controls differentiation through interactions that connect regions of nucleic acids and protein domains and through the assembly of biomolecular condensates. Here, we report that endoderm differentiation is regulated by the interaction between the long non-coding RNA (lncRNA) DIGIT ...
Kaveh Daneshvar, M Behfar Ardehali, Isaac A Klein   +2 more
exaly   +5 more sources

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2011
Acetylation of histones triggers association with bromodomain-containing proteins that regulate diverse chromatin-related processes. Although acetylation of transcription factors has been appreciated for some time, the mechanistic consequences are less well understood. The hematopoietic transcription factor GATA1 is acetylated at conserved lysines that
Stephan Kadauke, Amy E Campbell, Roland Gamsjaeger   +2 more
exaly   +5 more sources

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells. [PDF]

PLoS ONE, 2017
In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. We show that MLL-AF9 cells critically depend on FLT3-ligand induced pathways as well as on BRD3/4 for their survival. We evaluated the in vitro and in vivo
Marco Carretta, Annet Z Brouwers-Vos, Matthieu Bosman, Sarah J Horton, Joost H A Martens, Edo Vellenga, Jan Jacob Schuringa   +6 more
doaj   +7 more sources

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. [PDF]

PLoS ONE, 2016
Displacement of Bromodomain and Extra-Terminal (BET) proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET proteins in metabolic disease remain unexplored.
Jude T Deeney, Anna C Belkina, Orian S Shirihai, Barbara E Corkey, Gerald V Denis   +4 more
doaj   +5 more sources

BRD3 (bromodomain containing 3) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2017
BRD3 is a ubiquitously expressed member of the bromodomain and extraterminal motif (BET) family of proteins that use their tandem N-terminal bromodomains to associate with acetylated histones and transcription factors. Translocations involving BRD3 and NUT generate oncogenic fusion proteins that drive NUT midline carcinoma (NMC), an aggressive squamous
Werner, Michael T, Hsu, Sarah C, Blobel, Gerd A   +2 more
core   +4 more sources

mRNA display in cell lysates enables identification of cyclic peptides targeting the BRD3 extraterminal domain

Angewandte Chemie International Edition
ABSTRACT mRNA display is a powerful technology to screen libraries of >10 12 cyclic peptides against a protein target, enabling the rapid discovery of high affinity ligands. These cyclic peptides are particularly well suited to challenging protein targets that have been difficult
Catherine A. Hurd, Jacob T. Bush, Andrew J. Powell, Louise J. Walport   +3 more
core   +10 more sources

Hybrid AI/physics pipeline for miniprotein binder prioritization: application to the BRD3 ET domain.

Chem Commun (Camb)
AI-based protein design can rapidly generate thousands of candidate binders, but most fail to fold or bind productively, creating a critical need for robust prioritization.
Gaza J, Roth MJ, Montelione GT, Perez A.
europepmc   +3 more sources

Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3 [PDF]

Molecular and Cellular Biology, 2011
Recent data demonstrate that small synthetic compounds specifically targeting bromodomain proteins can modulate the expression of cancer-related or inflammatory genes. Although these studies have focused on the ability of bromodomains to recognize acetylated histones, it is increasingly becoming clear that histone-like modifications exist on other ...
Gamsjaeger, Roland (R16936), Webb, Sarah R., Lamonica, Janine M., Billin, Andrew, Blobel, Gerd A., Mackay, Joel P.   +5 more
openaire   +4 more sources

Correction: Hybrid AI/physics pipeline for miniprotein binder prioritization: application to the BRD3 ET domain.

Chem Commun (Camb)
Correction for ‘Hybrid AI/physics pipeline for miniprotein binder prioritization: application to the BRD3 ET domain’ by Jokent Gaza et al. , Chem. Commun. , 2025, 61 , 19028–19031, https://doi.org/10.1039 ...
Gaza J, Roth MJ, Montelione GT, Perez A.
europepmc   +2 more sources

Pulmonary Nuclear protein in Testis (NUT) carcinoma: clinical, molecular characteristics, and treatment strategies [PDF]

BMC Cancer
Background Pulmonary nuclear protein in testis (NUT) carcinoma is a rare and aggressive malignancy that often exhibits clinical and pathological features overlapping with other thoracic malignancies, posing significant challenges for accurate diagnosis ...
Jingjing Qu, Zhen Chen, Yanping Zhu, JinYan Huang, Qian Shen   +4 more
doaj   +2 more sources