Results 31 to 40 of about 3,728 (186)

77232 The role of the bromodomain and extra-terminal motif (BET) family of proteins in head and neck cancer tumorigenic phenotype

Journal of Clinical and Translational Science, 2021
IMPACT: Understanding the biology underpinning head and neck cancer invasion and metastasis could lead to novel targeted therapies that are both effective and tolerable for patients with this debilitating disease.
Reilly A. Sample, Rachel Paolini
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BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia

Journal of Immunology Research, 2022
Background. AML (acute myeloid leukemia) is a common hematological malignancy in children with poor treatment effects and poor prognosis. Recent studies have shown that as a novel BRD4 (bromodomain containing 4) PROTACs (proteolysis targeting chimeras ...
Xu Sang, Yongping Zhang, Fang Fang, Li Gao, Yanfang Tao, Xiaolu Li, Zimu Zhang, Jianwei Wang, Yuanyuan Tian, Zhiheng Li, Di Yao, Yumeng Wu, Xinran Chu, Kunlong Zhang, Li Ma, Lihui Lu, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Zhen Zhang, Jian Pan, Shaoyan Hu   +22 more
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BRD4: New hope in the battle against glioblastoma

Pharmacological Research, 2023
The BET family proteins, comprising BRD2, BRD3 and BRD4, represent epigenetic readers of acetylated histone marks that play pleiotropic roles in the tumorigenesis and growth of multiple human malignancies, including glioblastoma (GBM).
Weichen Duan, Miao Yu, Jiajia Chen
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Identification of photocrosslinking peptide ligands by mRNA display

Communications Chemistry, 2023
Photoaffinity labelling is a promising method for studying protein-ligand interactions. However, obtaining a specific, efficient crosslinker can require significant optimisation.
Yuteng Wu, M. Teresa Bertran, Dhira Joshi, Sarah L. Maslen, Catherine Hurd, Louise J. Walport   +5 more
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A Comprehensive Review of BET Protein Biochemistry, Physiology, and Pathological Roles

Frontiers in Pharmacology, 2022
Epigenetic modifications, specifically acetylation of histone plays a decisive role in gene regulation and transcription of normal cellular mechanisms and pathological conditions.
Hafiz Akbar Ali, Hafiz Akbar Ali, Yalan Li, Akram Hafiz Muhammad Bilal, Tingting Qin, Ziqiao Yuan, Wen Zhao, Wen Zhao   +7 more
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Physachenolide C is a Potent, Selective BET Inhibitor

, 2022
A pulldown using a biotinylated natural product of interest in the 17β-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), identified the bromodomain and extra-terminal domain (BET) family of proteins (BRD2, BRD3, and BRD4), readers of acetyl ...
Raimund Fromme (2565868), Ya-Ming Xu (1344258), Christopher J. Zerio (11595690), Nancy C. Horton (235826), Andrew J. Ambrose (4230583), Niloofar Ghadirian (14308019), Duc T. Ngo (14308013), E. M. Kithsiri Wijeratne (8262507), Eli Chapman (594753), Donna D. Zhang (261086), Jared Sivinski (11595708), A. A. Leslie Gunatilaka (8262510), Luis Villa-Celis (14308016), Michael W. Clarkson (2470651)   +13 more
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Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators

Cell Reports, 2019
Summary: Identifying proteins that function at replication forks is essential to understanding DNA replication, chromatin assembly, and replication-coupled DNA repair mechanisms.
Sarah R. Wessel, Kareem N. Mohni, Jessica W. Luzwick, Huzefa Dungrawala, David Cortez   +4 more
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Role of BET Proteins in Inflammation and CNS Diseases

Frontiers in Molecular Biosciences, 2021
Bromodomain and extra-terminal domain (BET) proteins consist of four mammalian members (BRD2, BRD3, BRD4, and BRDT), which play a pivotal role in the transcriptional regulation of the inflammatory response. Dysregulated inflammation is a key pathological
Lei Liu, Changjun Yang, Eduardo Candelario-Jalil   +2 more
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Supplementary Data from Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma

, 2021
Supplementary Figure 3. Individual dsiRNA knockdown targeting BRD2 and BRD3 in OCI-C5x cells.
Christopher J. Kemp (221372), Shogo Shigeta (9969498), Goldie Y.L. Lui (15088834), Robert L. Diaz (14895831), Elizabeth M. Swisher (14942481), Rachele Rosati (15003246), Grace Durenberger (15088837), Russell Moser (14956812), Tan A. Ince (14906331), Reid Shaw (15005711), Carla Grandori (263244), Kay E. Gurley (8660796)   +11 more
core   +1 more source

The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target

Cell Journal, 2017
Cancer cells have recently been shown to activate hundreds of normally silent tissue-restricted genes, including a specific subset associated with cancer progression and poor prognosis.
Ekaterina Flin, Florent Chuffart, Sophie Rousseaux, Saadi Khochbin   +3 more
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