Results 71 to 80 of about 3,728 (186)

Expanding the spectrum of non-canonical NUT carcinoma: clinicopathological and molecular characterization of BRD3::NUTM1 and WWTR1::NUTM1 fusion variants

Frontiers in Oncology
IntroductionNuclear protein in testis (NUT) carcinoma (NC) is an extremely rare and highly aggressive tumor. Non-canonical NC patients frequently have unique clinicopathological characteristics in terms of location, molecular alteration, and outcome ...
Zuoyu Liang, Chan Yang, Chan Yang, Xiaoqian Zhai, Yan Wang, Min Chen, Mei Tang, Linlin Huang, Mengqian Li, Ping Zhou, Xuexue Wu, Ji Bao, Dongni Liang, Dongni Liang, Lili Jiang, Weiya Wang   +15 more
doaj   +1 more source

The expanding universe of NUTM1 fusions in pediatric cancer

Clinical and Translational Science, 2023
NUT midline carcinoma family member 1 (NUTM1) fusions were originally identified in poorly differentiated and clinically aggressive carcinomas typically located in the midline structures of children and young adults, and collectively known as NUT ...
Rosane Charlab, Rebecca Racz
doaj   +1 more source

The Selective Bromodomain and Extra‐Terminal Domain (BET) Inhibitor RVX‐208 Reduces Cocaine‐Seeking Behaviour and Alters Proteomic Pathways in the Nucleus Accumbens

Addiction Biology, Volume 31, Issue 1, January 2026.
Rats treated with the domain‐selective BET inhibitor RVX‐208 during a 2‐week forced abstinence period exhibited a reduction in cocaine‐seeking behaviour but not sucrose seeking or open field behaviour. This treatment effect was associated with proteomic changes in pathways relevant to dopaminergic and glutamatergic signalling in the nucleus accumbens ...
Tyler J. Sacko, Afshin Seyednejad, Jesse Engelhardt, Gregory C. Sartor   +3 more
wiley   +1 more source

BRD4 regulates self‐renewal ability and tumorigenicity of glioma‐initiating cells by enrichment in the Notch1 promoter region

Clinical and Translational Medicine, 2020
Bromodomain and extraterminal domain (BET) family proteins are considered to be epigenetic readers that regulate gene expression by recognizing acetyl lysine residues on histones and nonhistone chromatin factors and have been classified as curative ...
Zhennan Tao, Xuetao Li, Hao Wang, Guangliang Chen, Zibin Feng, Yue Wu, Haoran Yin, Guozheng Zhao, Zhitong Deng, Chaohui Zhao, Yanyan Li, Ting Sun, Youxin Zhou   +12 more
doaj   +1 more source

Correspondence: Primary Cutaneous NUT Adnexal Carcinoma: A Case Report With Novel Clinical and Pathological Observations

Journal of Cutaneous Pathology, Volume 53, Issue 7, Page 622-623, July 2026.
Woo Cheal Cho
wiley   +1 more source

Investigating Dysbiosis‐Driven Colonization by Staphylococcus aureus and the Mitigative Potential of Medicinal Plants in Diabetes‐Linked Inflammation

Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
Objective Antibiotic‐induced dysbiosis predisposes hosts to colonization by opportunists such as Staphylococcus aureus, with downstream metabolic and inflammatory consequences. This study evaluated the physiological impact of dysbiosis and S. aureus challenge in rats and tested three Nigerian medicinal plants, Vernonia amygdalina (Bitter Leaf ...
Kehinde Abel Ajadi, Oluwapelumi Oyindamola Ogunleye, Adeogo Oreoluwa Jibodu, Awele Oluwayemisi Abuah, Olajide Olasubomi Diya, Benedicta Bialichukwu Onochie, Princess Okeoghene Irivradje, Oore-oluwapo Ololade Daramola, Adeleke Osho, Jian Wu   +9 more
wiley   +1 more source

Construction and verification of a histone deacetylases-related prognostic signature model for colon cancer

Scientific Reports
Histone deacetylases (HDACs) contribute significantly to the initiation, progression, and prognosis of colorectal adenocarcinoma (COAD). Additionally, HDACs regulate the tumor microenvironment, immune escape, and tumor stem cells, and are closely linked ...
Lei Hao, Weiqi Lu, Jianyu Wu, Yuzhong Chen, Dongni Xu, Peizong Wang   +5 more
doaj   +1 more source

Effects of the BET Bromodomain Inhibitor OTX015 on Epithelial–Mesenchymal Transition in Human Pancreatic Cancer Cells

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Background This study aimed to explore the role of the bromodomain and extraterminal (BET) inhibitor OTX015 in pancreatic cancer cells and to investigate the potential mechanisms underlying its association with epithelial–mesenchymal transition (EMT).
Shan Zhao, Yaman Chen, Zuzhi Tang, Anle Huang, Zhiwen Luo   +4 more
wiley   +1 more source

Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma

, 2021
Ovarian clear cell carcinoma (OCCC) is a rare, chemo-resistant subtype of ovarian cancer. To identify novel therapeutic targets and combination therapies for OCCC, we subjected a set of patient-derived ovarian cancer cell lines to arrayed high-throughput
Rosati, Rachele, Kemp, Christopher J, Moser, Russell, Durenberger, Grace, Shigeta, Shogo, Shaw, Reid, Swisher, Elizabeth M, Grandori, Carla, Gurley, Kay E, Diaz, Robert L, Ince, Tan A, Lui, Goldie Y L   +11 more
core   +1 more source

In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations

Frontiers in Pharmacology
Oral cancer is a severe health problem that accounts for an alarmingly high number of fatalities worldwide. Withania somnifera (L.) Dunal has been extensively studied against various tumor cell lines from different body organs, rarely from the oral ...
Ahmed Abdullah Al Awadh, Hiroshi Sakagami, Shigeru Amano, Ahmed M. Sayed, Ahmed M. Sayed, Mohamed E. Abouelela, Abdulaziz Hassan Alhasaniah, Nayef Aldabaan, Mohamed S. Refaey, Reda A. Abdelhamid, Heba M. A. Khalil, Dalia I. Hamdan, El-Shaymaa Abdel-Sattar, Mohamed A. A. Orabi   +13 more
doaj   +1 more source