Results 91 to 100 of about 3,728 (186)
Stem Cell Research, 2016 Neural stem cells and progenitor cells (NPCs) are increasingly appreciated to hold great promise for regenerative medicine to treat CNS injuries and neurodegenerative diseases.
Jingjun Li +14 more
doaj +1 more source
Differentially expressed genes in endothelial differentiation
, 2005 By screening differentially expressed genes in mouse embryonic stem (ES) cells by subtractive hybridization, we identified three conserved but uncharacterized genes encoding bromodomain containing 3 (BRD3), protein lysine methyltransferase (PLM), and ...
Hideshi Ishii +3 more
core +1 more source
Binding of BET bromodomain mutants to acetylated histone peptides and inhibitors.
, 2016 (A) BLI study showing the interaction of some mutants with acetylated histone peptides. Shown is the maximum response at a protein concentration of 20 μM after subtraction of non-acetylated reference peptides using a colour code as indicated in the ...
Cynthia Tallant (372948) +7 more
core +1 more source
MoleculesA 3D structure-based pharmacophore model built for bromodomain-containing protein 4 (BRD4) is reported here, specifically developed for investigating and identifying the key structural features of the (+)-JQ1 known inhibitor within the BRD4 binding site.
Ester Colarusso +7 more
doaj +1 more source
brd3a is an important regulator of thrombopoiesis.
, 2014 (A) Live confocal imaging of zebrafish embryos injected with hBRD3-GFP mRNA revealed the nuclear localization of hBRD3 and that it binds to mitotic chromosomes (white arrows).
Lauren Ferreira (595949) +6 more
core +1 more source
Supplementary Figure 3 from Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma
, 2013 PDF file - 4 MB, (A) Reduced expression of BRD2, BRD3, BRD4 following expression of corresponding shRNA sequences was determined by qRT-PCR in T4302 CD133+ cells.
Reid C. Thompson (14985159) +9 more
core +1 more source
Figure S6 from BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer
, 2019 Figure S6. BRD3 and BRD4 are associated with disease-specific survival in METABRIC cohort.
Suet-Feung Chin (13233) +21 more
core +1 more source
Scientific Reports, 2017 The bromodomain protein Brd4 is an epigenetic reader and plays a critical role in the development and maintenance of leukemia. Brd4 binds to acetylated histone tails and activates transcription by recruiting the positive elongation factor P-TEFb.
Tim-Michael Decker +6 more
doaj +1 more source
Effect of siRNAs directed toward different BET proteins on ApoA-I mRNA levels in Huh7 cells.
, 2013 A. Individual BRD2 and pooled BRD3 siRNAs. siRNAs were transfected for 48% DMSO. Protein knockdown was 56%, 42% and 44% for Brd2#1, #2 and #3 siRNAs and 86% for pooled Brd3 siRNAs. B. Individual BRD4 siRNAs.
Robert K. Suto (504423) +14 more
core +1 more source
Case Reports in Pathology, 2015 Background. Nuclear protein in testis (NUT) midline carcinoma (NMC) is a very rare and aggressive malignancy. In more than two-thirds of these NMC cases, a fusion between NUT and BRD4 or BRD3 has been documented; other variants are rare.
Shiho Kuroda +6 more
doaj +1 more source