Results 161 to 170 of about 3,728 (186)
Molecular regulation of BRD3 in forward programming of Megakaryocytes
, 2019 Platelets are one of the most abundant cell type in the blood, and they play a crucial role in the process of homeostasis. Platelet traits, such as platelet count (PLT) and mean platelet volume (MPV) are highly heritable and stable within individuals, but the molecular mechanisms controlling these traits are poorly understood.
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A non-canonical immunometabolic function of BRD3 during sepsis
Developmental CellSepsis is a life-threatening condition characterized by a dysregulated host innate immune response to pathogen infection. Here, we identify a pathological role for bromodomain-containing 3 (BRD3) in driving septic shock by upregulating aconitate decarboxylase 1 (ACOD1) in monocytes and macrophages via a non-canonical pathway.
Chunhua Yu, Daolin Tang
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European Journal of Medicinal Chemistry, 2023
Targeted degradation of BET family proteins BRD2/3/4 or only BRD4 with PROTAC molecules has been a promising strategy for the treatment of human cancer. Meanwhile, selective degradation of cellular BRD3 and BRD4-L remains a challenging task. We report herein a novel PROTAC molecule 24 that promoted selective degradation of cellular BRD3 and BRD4-L, but
Ziqin Yan, Xilin Lyu, Yujun Zhao
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Targeted degradation of BET family proteins BRD2/3/4 or only BRD4 with PROTAC molecules has been a promising strategy for the treatment of human cancer. Meanwhile, selective degradation of cellular BRD3 and BRD4-L remains a challenging task. We report herein a novel PROTAC molecule 24 that promoted selective degradation of cellular BRD3 and BRD4-L, but
Ziqin Yan, Xilin Lyu, Yujun Zhao
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Ku70 targets BRD3-MYC/Cyclin D1 axis to drive hepatocellular carcinoma progression
Experimental Cell ResearchHepatocellular carcinoma (HCC) is a common cancer characterized by robustly proliferative and metastatic capabilities. Bromodomain-containing proteins are critical to the development of diverse diseases via regulating cell proliferation, differentiation, and death. However, the role of Bromodomain-containing protein 3 (BRD3) in HCC is elusive. Here, we
Cuifu Yu, Gengxi Cai, Qiucheng Lei
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Achieving theranostic probes targeting BRD3/BRD4 for imaging and therapy of tumor
European Journal of Medicinal ChemistryThe BET family proteins play pleiotropic roles in the tumorigenesis and growth of various human malignancies that have aroused great interests as the cancer therapeutic targets. Therefore, it's significant to develop labeling toolkits for the dynamic monitoring of BET family proteins in living tumor cells and tissue slices. In particular, there are few
Cong Song, Tingting Liu
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Structural Insights into Human Epigenetic Regulation from the Proteins SETD7 and Brd3 [PDF]
, 2021 Epigenetics—the study of the layer of gene regulation not accounted for by the DNA sequence itself—is a burgeoning field increasingly tied to diseases such as cancer and Alzheimer’s disease in humans. A prevailing avenue of current research is the so-called histone code—the large number of posttranslational modifications (PTMs) made to the histone ...
Woodmansey, James Nicolas
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Skin adnexal carcinoma with
AbstractNUT carcinomas are genetically defined epithelial neoplasms. Most tumors harbor fusions of NUTM1 with BRD4 or BRD3. Their histopathologic features have been predominantly reported as undifferentiated or poorly differentiated squamous cell carcinoma, and clinically they tend to be aggressive cancers.
Belen Rubio Gonzalez +3 more
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Cellular and Molecular Life Sciences, 2022
The bromodomain and extraterminal motif (BET) proteins are critical drug targets for diseases. The precise functions and relationship of BRD2 with other BET proteins remain elusive mechanistically. Here, we used acute protein degradation and quantitative genomic and proteomic approaches to investigate the primary functions of BRD2 in transcription.
Chenlu Wang +8 more
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The bromodomain and extraterminal motif (BET) proteins are critical drug targets for diseases. The precise functions and relationship of BRD2 with other BET proteins remain elusive mechanistically. Here, we used acute protein degradation and quantitative genomic and proteomic approaches to investigate the primary functions of BRD2 in transcription.
Chenlu Wang +8 more
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GATA1 and the BET Family Protein Brd3 Form a Mitotic Bookmarking Complex
Blood, 2012Abstract Abstract 282 Erythroid-specific transcription patterns are maintained throughout cell division. During mitosis, transcription is silenced globally. This raises the question whether mechanisms are in place that ensure the spatially and temporally correct reassembly of transcriptional regulators and thus maintain ...
Stephan Kadauke +5 more
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Acetylation-Dependent Interaction of GATA-1 with the Potential Mitotic “Bookmarking” Protein Brd3.
Blood, 2010Abstract Abstract 2598 Acetylation of the transcription factor GATA-1 facilitates its ability to drive erythroid differentiation by enhancing its association with in vivo target sites. However, the underlying mechanism through which GATA-1 acetylation functions has remained elusive.
Janine M Lamonica +3 more
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