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First-Line Treatment of Advanced Thoracic SMARCA4-Deficient Undifferentiated Tumor: A Case Report and Review of the Literature. [PDF]
Case Rep Oncol MedWen Q +6 more
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International Journal of Molecular Sciences, 2023 BRG1 is one of two catalytic subunits of the SWI/SNF ATP-dependent chromatin-remodeling complex. In cancer, it has been hypothesized that BRG1 acts as a tumor suppressor. Further study has shown that, under certain circumstances, BRG1 acts as an oncogene.
Aaron Shaykevich +2 more
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Clinicopathologic Characteristics of BRG1-Deficient NSCLC [PDF]
Journal of Thoracic Oncology, 2020 Ten percent of NSCLCs harbor mutations in SMARCA4, the gene encoding the SWItch/Sucrose Non-Fermentable ATPase BRG1. In preclinical models, BRG1 inactivation increases tumor aggressiveness but enhances sensitivity to drugs that target oxidative phosphorylation and inhibit SMARCA2, EZH2, CDK4, or CDK6.
Ibiayi Dagogo-Jack +2 more
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The role of BRG1 in epigenetic regulation of cardiovascular diseases
European Journal of Pharmacology, 2023Cardiovascular diseases have been closely linked to abnormal epigenetic regulation. In the context of epigenetic regulation, BRG1, a pivotal SWI/SNF chromatin remodeling enzyme, emerges as a key epigenetic regulator with significant impact on the development and progression of cardiovascular disorders.
Zi-Yue, Ma +6 more
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A role for BRG1 in vascular development
The FASEB Journal, 2007ATP‐dependent chromatin‐remodeling complexes such as the mammalian SWI/SNF‐related complexes BAF and PBAF can alter the conformation or position of nucleosomes, thereby affecting the ability of large nuclear factors to access gene promoters.
Courtney Griffin +2 more
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Production of a Rat Monoclonal Antibody Against Brg1
Hybridoma, 2009Brm-related gene-1 (Brg1) is a catalytic subunit of the SWI/SNF chromatin remodeling enzyme complex that has ATPase activity. This complex facilitates chromatin remodeling for gene expression by utilizing energy for ATP hydrolysis. It is well known that the SWI/SNF chromatin remodeling enzyme complex is essential for cell differentiation, cell cycle ...
Yasuyuki, Ohkawa +4 more
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BRG1 is correlated with poor prognosis in colorectal cancer
Human Pathology, 2018Brahma-related gene 1 (BRG1), a component of the chromatin-remodeling complex, regulates transcription by remodeling the chromatin structure. The present study aimed to elucidate the clinicopathological significance and prognostic role of BRG1 in colorectal cancer (CRC).
Jung-Soo, Pyo +3 more
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Brg1 mutation alters oxidative stress responses in glioblastoma
Neurochemistry International, 2021Increasing evidences suggest that the SWI/SNF chromatin remodeling complex involved in the organization of chromatin architecture via ATP hydrolysis, plays an important role in human cancer. As TCGA gene expression analyses revealed signature of enhanced oxidative stress in GBMs harbouring Brg1mutations, we examined the involvement of ATPase subunit of
Pruthvi Gowda +3 more
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HMGA1 Mediates the Activation of the CRYAB Promoter by BRG1
DNA and Cell Biology, 2007alphaB-Crystallin (CRYAB) is a small heat-shock protein that is implicated in many cellular processes, such as transcription and differentiation, as well as pathologic process. It is expressed at high levels in vertebrate eye lens and at low levels in a variety of other cell types.
Beverly, Duncan, Keji, Zhao
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