Results 241 to 250 of about 871,553 (293)

Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques. [PDF]

Cell Rep
Morris DJ, Gorman J, Zhou T, Lora J, Connell AJ, Li H, Liu W, Roark RS, Campion MS, Carey JW, Habib R, Li Y, Martella CL, Park Y, Singh A, Sowers KJ, Teng IT, Wang S, Chohan N, Ding W, Lauer C, Lewis E, Mason RD, Rando JM, Peyton L, Schramm CA, Wagh K, Korber B, Seaman MS, Douek DC, Haynes BF, Kulp DW, Roederer M, Hahn BH, Kwong PD, Shaw GM.   +35 more
europepmc   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Design clues from functional constraints and broadly neutralizing antibodies

Retrovirology, 2006
Dimitrov Dimiter S, Burton Dennis R, Arthos James, Zwick Michael B, Zhang Mei-Yun, Yang Xinzhen, Xiang Shi-Hua, Van Ryk Donald, Majeed Shahzad, Hessell Ann J, Dey Barna, Xu Ling, Zhou Tongqing, Sodroski Joseph, Wyatt Richard, Nabel Gary J, Kwong Peter D   +16 more
doaj   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Genetic signatures in the highly virulent subtype B human immunodeficiency virus-1 conferring resistance to broadly neutralizing antibodies. [PDF]

iScience
Honnayakanahalli Marichannegowda M, Agyekum G, Aparicio CZ, Heredia A, Wang Y, Song H.   +5 more
europepmc   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies. [PDF]

Nat Commun
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF.   +25 more
europepmc   +1 more source

Reshaping antivenom therapy: A triple-synergy strategy featuring broadly neutralizing antibodies and a small-molecule PLA₂ inhibitor. [PDF]

Acta Pharm Sin B
Zhou Y, Shi N, Gao X, Luo L.
europepmc   +1 more source

Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins. [PDF]

MAbs
Wade J, Štrancar N, Fernández-Quintero ML, Siebenhaar S, Jansen T, Meier EPW, Jenkins TP, Bjørn SP, Nguyen GTT, Lomonte B, Gutiérrez JM, Sørensen CV, Loeffler JR, Paul A, Tulika T, Arnsdorf J, Schoffelen S, Lundquist EVS, Sørensen J, Ward AB, Voldborg BG, Bohn MF, Rivera-de-Torre E, Morth JP, Laustsen AH.   +24 more
europepmc   +1 more source

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection. [PDF]

Commun Biol
Yu L, Wang Y, Liu Y, Xing X, Li C, Wang X, Shi J, Ma W, Li J, Chen Y, Qiao R, Zhao X, Tian S, Gao M, Wen S, Xue Y, Qiu T, Yu H, Guan Y, Chu H, Sun L, Wang P.   +21 more
europepmc   +1 more source