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Virologic effects of broadly neutralizing antibodies VRC01LS and VRC07-523LS on chronic HIV-1 infection. [PDF]
Happe M +37 more
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Cost-effectiveness of broadly neutralizing antibodies for HIV prophylaxis for infants born in settings with high HIV burdens. [PDF]
Alba C +23 more
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Isolation and escape mapping of broadly neutralizing antibodies against emerging delta-coronaviruses. [PDF]
Rexhepaj M +20 more
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Delivery platforms for broadly neutralizing antibodies
Current Opinion in HIV and AIDS, 2023Purpose of review Passive administration of broadly neutralizing antibodies (bNAbs) is being evaluated as a therapeutic approach to prevent or treat HIV infections. However, a number of challenges face the widespread implementation of passive transfer for HIV. To reduce the need of recurrent administrations of bNAbs, gene-based
Lok R, Joshi +4 more
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Broadly neutralizing antibodies against influenza viruses [PDF]
Despite available antivirals and vaccines, influenza continues to be a major cause of mortality worldwide. Vaccination generally induces an effective, but strain-specific antibody response. As the virus continually evolves, new vaccines have to be administered almost annually when a novel strain becomes dominant.
Ian Andrew Wilson, Nick S Laursen
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Broadly neutralizing antibodies in HIV-1 treatment and prevention
Antibodies that naturally develop in some individuals infected with human immunodeficiency virus 1 (HIV-1) and are capable of broadly neutralizing diverse strains of HIV-1 are useful for two applications: they can inform the rational design of vaccine ...
Jayanta Bhattacharya +2 more
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Broadly Neutralizing Antibodies for HIV Prevention
Annual Review of Medicine, 2020In the last decade, over a dozen potent broadly neutralizing antibodies (bnAbs) to several HIV envelope protein epitopes have been identified, and their in vitro neutralization profiles have been defined. Many have demonstrated prevention efficacy in preclinical trials and favorable safety and pharmacokinetic profiles in early human clinical trials ...
Shelly T, Karuna, Lawrence, Corey
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Summary: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on
Michael S Seaman +2 more
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In vivo protection by broadly neutralizing HIV antibodies
Trends in Microbiology, 2014Passive immunization studies, including a recent one by Pegu et al., have repeatedly shown that HIV-specific broadly neutralizing antibodies (bnAbs) protect rhesus macaques from HIV acquisition. In vitro neutralization potency and in vivo protection correlate very strongly, supporting the quest for an HIV vaccine that induces potent bnAbs.
Marit J. van Gils, Rogier W. Sanders
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A recipe for inducing broadly neutralizing antibodies
Nature Reviews Immunology, 2016An immune profile associated with the production of broadly neutralizing antibodies is identified in HIV-1-infected individuals.
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