Results 81 to 90 of about 37,262 (190)

Epigenomes in Cardiovascular Disease. [PDF]

, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA, Morimoto T, Poller W, Turner BM, Wang Y   +4 more
core   +1 more source

Expression and purification of an NSD3-GB1 fusion protein as a way to study the structure of complex formation with Brd4 ET. [PDF]

, 2020
The BRD4 protein belongs to the bromodomain and extraterminal domain (BET) family of eukaryotic transcription factors, and is linked to several types of cancer, inflammation, and obesity.
Tuokkola, Jennifer
core  

New synthetic routes to Triazolo-benzodiazepine analogues:expanding the scope of the bump-and-hole approach for selective Bromo and Extra-Terminal (BET) bromodomain inhibition [PDF]

, 2015
We describe new synthetic routes developed toward a range of substituted analogues of bromo and extra-terminal (BET) bromodomain inhibitors I-BET762/JQ1 based on the triazolo-benzodiazepine scaffold.
Alessio Ciulli, Cynthia Tallant, Enrique Lin-Shiao, Matthias G. J. Baud, Michael Zengerle, Sternbach L. H.   +5 more
core   +4 more sources

Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains

Journal of Biological Chemistry
Promoter-promoter and enhancer-promoter interactions are enriched in histone acetylation and central to chromatin organization in active genetic regions. Bromodomains are epigenetic "readers" that recognize and bind histone acetylation. Bromodomains often exist in tandem or with other reader domains.
Michael D. Olp, Karina L. Bursch, Sarah L. Wynia-Smith, Raymundo Nuñez, Christopher J. Goetz, Vaughn Jackson, Brian C. Smith   +6 more
openaire   +2 more sources

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science
Blood‐brain barrier (BBB) disruption is central to neurodegenerative and cerebrovascular diseases, but its causal role and therapeutic targeting remain challenging.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
doaj   +1 more source

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter. [PDF]

, 2017
The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by ...
Ao, Ming-Tao, Fang, Mei-Juan, Gao, Xiang, Shao, Rui, Wang, Hui-Ru, Wu, Jun, Wu, Zhen, Xue, Yu-Hua, Yu, Diao, Zhou, Qiang   +9 more
core   +2 more sources

Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer [PDF]

, 2013
PurposeAmplification of MYC is one of the most common genetic alterations in lung cancer, contributing to a myriad of phenotypes associated with growth, invasion and drug resistance.
Akbay, Esra, Bradner, James E., Carretero, Julian, Chen, Zhao, Cheng, Katherine A., Cohoon, Travis J., Gao, Yandi, Kikuchi, Eiki, Kimmelman, Alec C., Kung, Andrew L., Qi, Jun, Shimamura, Takeshi, Soucheray, Margaret, Tchaicha, Jeremy H., Wong, Kwok-Kin   +14 more
core   +1 more source

The discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition [PDF]

, 2016
Acetylation of histone lysine residues is one of the most well-studied post-translational modifications of chromatin, selectively recognized by bromodomain “reader” modules.
Andrew J. Bannister, Anne-Marie Michon, Antje Dittmann, Arrowsmith C. H., Bagnyukova T. V., Bamborough P., Baud M. G. J., Borah J. C., Brand M., Bunnage M. E., Chun-wa Chung, Chung C. W., Chung C. W., Chung C. W., Chung C. W., David H. Drewry, Dawson M. A., Demont E. H., Fedorov O., Ferguson F. M., Filippakopoulos P., Filippakopoulos P., Filippalopoulos P., Fish P. V., Furdas S. D., Gardner K. E., Garnier J. M., Gentile G., Gerard Drewes, Gosmini R., Guetzoyan L., Harner M. J., Hay D. A., Hewings D. S., Hewings D. S., Hewings D. S., Hohmann A. F., Hongbin S., Isabelle Becher, Jennings L. E., Judit Molnar, Ka Hing Che, Kadoch C., Knapp S., Laurie Gordon, Mathews T. P., Matthew Lindon, McKeown M. R., McLure K. G., Melanie Leveridge, Middeljans E., Mirguet O., Mirguet O., Morinière J., Mujtaba S., Müller S., Natalie H. Theodoulou, Nicholas C. O. Tomkinson, Nicodeme E., Paola Grandi, Paul Bamborough, Philip G. Humphreys, Picaud S., Prinjha R. K., Rab K. Prinjha, Rino A. Bit, Rooney T. P. C., Samuel C. Robson, Sanchez R., Sattler S., Scotto L., Seal J., Sweis R. F., Tony Kouzarides, Vollmuth F., Yan Y., Young R. J., Zeng L., Zhang G., Zhang S.   +79 more
core   +2 more sources

Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]

, 2015
Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C, Kwok, Rosanna S, Lam, Vu H   +2 more
core   +1 more source

Bromodomain-containing protein 4 knockdown promotes neuronal ferroptosis in a mouse model of subarachnoid hemorrhage

Neural Regeneration Research
Neuronal cell death is a common outcome of multiple pathophysiological processes and a key factor in neurological dysfunction after subarachnoid hemorrhage. Neuronal ferroptosis in particular plays an important role in early brain injury.
Peng Lu, Fan Zhang, Lei Yang, Yijing He, Xi Kong, Kecheng Guo, Yuke Xie, Huangfan Xie, Bingqing Xie, Yong Jiang, Jianhua Peng   +10 more
doaj   +1 more source