Results 21 to 30 of about 417 (140)

Type‐2‐Inflammatory‐Diseases Share Comorbidities, Molecular Signatures, IL4/IL13 Genetics, and Response to IL4/IL13 Blockade

Allergy, EarlyView.
Studies suggest that type 2 inflammatory diseases are driven by overactivation of the IL4/IL13 pathway, manifesting differently in distinct tissues. We performed quantitative analyses using several large independent datasets to explore the interrelation of type 2 inflammatory diseases based on co‐prevalence, genetic predispositions, and transcriptomic ...
Jennifer D. Hamilton, Manuel A. R. Ferreira, Wei Keat Lim, Carlo Sidore, Matthew F. Wipperman, Wenzhen Ge, Xue Song, Changming Xia, Julie E. Horowitz, Andrea T. Hooper, Sara C. Hamon, Jennifer Maloney, Jamie M. Orengo, Zhen Chen, Stephanie Amato Ricci, Bolanle Akinlade, Aris Baras, Gary Herman, Brandy L. Bennett, George D. Yancopoulos   +19 more
wiley   +1 more source

Is Asthma Remission a New Achievable Goal? A Review of the Current Drug‐Related Evidence and Predictors

Allergy, EarlyView.
ABSTRACT Advances in asthma therapies have shown that clinical remission may be an achievable therapeutic goal for patients with asthma. This review discusses the current definitions of remission in asthma, the predictors of remission, airway inflammation/epithelial damage in asthma remission, airway remodeling, paradigms in defining remission and ...
Fatma Esra Gunaydin, Giulia Marcassa, Bianca Olivieri, Gianenrico Senna, Marco Caminati   +4 more
wiley   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Deaths certified as asthma and use of medical services: A national case-control study

, 2005
This is an open access publication. The official published version can be accessed from the link below.Background: Studies have linked asthma death to either increased or decreased use of medical services.
Sturdy, PM, Anderson, HR, Victor, CR, Peckitt, C, Butland, BK, Harrison, BDW, Ayres, JG, Bland, JM   +7 more
core   +1 more source

Management of Paediatric Acute Asthma in a Metropolitan Emergency Department: A Retrospective Audit

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim To evaluate adherence to the Sydney Children's Hospital Network (SCHN) Asthma‐Acute Management Practice Guideline in the management of paediatric patients presenting to a metropolitan emergency department (ED). Methods A cross‐sectional retrospective audit of 153 paediatric ED presentations with acute asthma between March 2023 and February
Yasmine Toufaili, Nounu Sarukkali
wiley   +1 more source

Association of Nasal and Inhalant Corticosteroids With Pediatric Perioral Dermatitis: A TriNetX Retrospective Cohort Study

Pediatric Dermatology, EarlyView.
ABSTRACT Although topical corticosteroids are known triggers in the development of perioral dermatitis (PD), investigation into inhalant and nasal corticosteroid preparations, commonly used to manage allergic rhinitis and asthma, remains limited to case series.
Taylor Merkle, Caitlyn Curley, Dylan Wambold, Basira Iginla, Erum N. Ilyas   +4 more
wiley   +1 more source

asthma and anti-asthmatic agents

, 2022
asthma is chronic inflammation of airway which causes shortness of breath, repeated coughing and wheezing. The treatment is bronchodilator, mast cell stabilizer, corticosteroid, anti IgE.gyógyszerészangolegységes ...
sherkat, fatemeh
core  

Effect of foot immersion and neck cooling on renal, intestinal, immune and inflammatory markers in older adults exposed to extreme heat

Experimental Physiology, EarlyView.
Abstract Older adults with reduced thermoregulatory capabilities are increasingly at risk of heat‐related pathophysiological outcomes (e.g., acute kidney injury, heatstroke) due to increasingly frequent, prolonged and intense heatwaves. Foot immersion and neck cooling have been proposed as practical, non‐electrical cooling strategies for protecting ...
Thomas McCarthy, Ben J. Lee, James J. McCormick, Kelli E. King, Emma R. McCourt, Luana C. Main, Robert D. Meade, Glen P. Kenny   +7 more
wiley   +1 more source

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 178-192, July 2026.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source