Results 41 to 50 of about 417 (140)

Fentanyl Compromises Lower‐Airway Mechanics and Naloxone Triggers a Transient Mechanical Overshoot

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Opioid‐induced respiratory depression (OIRD) is the leading cause of death following opioid overdose, due to its effects on central rhythm generation, and airway and thoracic constriction. While the effects on rhythm generation have been well documented, the effects of fentanyl on airway constriction are less well understood. We tested the
Riley R. Parks, Marissa J. Andersen, Mackenna L. Hatfield, Madeline M. Johnson, Nicholas J. Burgraff   +4 more
wiley   +1 more source

Effects of long-term bronchodilators in bronchiectasis patients with airflow limitation based on bronchodilator response at baseline

, 2016
Ho Jung Jeong,1,* Hyun Lee,1,* Keumhee C Carriere,2,3 Jung Hoon Kim,1 Jin-Hyung Han,1 Beomsu Shin,1 Byeong-Ho Jeong,1 Won-Jung Koh,1 O Jung Kwon,1 Hye Yun Park1 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical ...
Carriere KC, Shin B, Kwon OJ, Jeong HJ, Park HY, Koh WJ, Lee H, Kim JH, Jeong BH, Han JH   +9 more
core  

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, Volume 183, Issue 11, Page 2660-2674, June 2026.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Current Evidence on the Usefulness of Potential Therapies in the Prevention of COPD Exacerbations: Beyond the Use of Bronchodilator Therapy and Inhaled Corticosteroids [PDF]

Prevention of exacerbations is a key objective in chronic obstructive pulmonary disease (COPD) management. The adverse effects of an exacerbation include a negative impact on patient quality of life and symptoms, an accelerated rate of decline in lung ...
Hurtado-Fuentes, Álvaro, Callejas-González, Francisco Javier, Miguel-Díez, Javier de, Golpe, Rafael, Marín-Oto, Marta, Loscertales-Vacas, Guillermo Samuel, Máiz-Carro, Luis, Figueira-Gonçalves, Juan Marco, Tordera-Mora, José María   +8 more
core   +1 more source

Respiratory Biomarkers: An Opportunity for Patient‐Centric Microsampling Approach for Treatment Optimization

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
Overview of patient centric microsampling approach for monitoring respiratory biomarkers for treatment optimization. Image created in BioRender. Khan, A. (2026) https://BioRender.com/17jm5cs. ABSTRACT The clinical heterogeneity of respiratory disorders emphasizes the need for personalized approaches to prevention, diagnosis, and therapy.
Ahmar Khan, Jacqueline L. Stair, Daniel Baker, Neil Spooner, Darragh Murnane   +4 more
wiley   +1 more source

New beta-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents

, 1998
WOS: 000075057400007PubMed ID: 9689423Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5-dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities ...
Balkan, A, Akgün, H, Erol, Kevser, Batu, Ö. S.   +3 more
core  

Occupational asthma due to low molecular weight agents: eosinophilic and non-eosinophilic variants.

, 2002
BACKGROUND: Despite having a work related deterioration in peak expiratory flow (PEF), many workers with occupational asthma show a low degree of within day diurnal variability atypical of non-occupational asthma.
Pavord, ID, Huggins, V, Robertson, AS, Anees, W, Burge, PS   +4 more
core   +1 more source

A Qualitative Exploration of Unanticipated Effects Experienced By People With Chronic Obstructive Pulmonary Disease Who Participated in Interventions Designed to Reduce Sedentary Behaviour

Health Expectations, Volume 29, Issue 3, June 2026.
ABSTRACT Introduction This study explored the lived experiences of people with chronic obstructive pulmonary disease (COPD) who participated in interventions designed to reduce the accumulation of sedentary behaviour in prolonged uninterrupted bouts. Methods Ten participants with stable COPD participated in a multi‐component intervention that spanned ...
Fiona Coll, Vinicius Cavalheri, Daniel F. Gucciardi, Kylie Hill   +3 more
wiley   +1 more source

Long-acting β2-adrenergic receptor agonist in pediatric asthma

, 2004
Long-acting β2-adrenergic receptor agonists (LABA), a class of agents for the long-term management of childhood bronchial asthma, are recommended for use in combination with steroid inhalation for the treatment of the morning dip in severe childhood ...
Yoshihara, Shigemi, Osamu Arisaka, Yumi Yamada, Yamada, Yumi, Toshio Abe, Arisaka, Osamu, Abe, Toshio, Shigemi Yoshihara   +7 more
core   +1 more source

Impact of Respiratory Viral Codetections on RSV Disease Burden in Young Children in Primary Care

Influenza and Other Respiratory Viruses, Volume 20, Issue 6, June 2026.
ABSTRACT Background Young children with respiratory syncytial virus (RSV) often have viral coinfections. This study assessed the impact of respiratory viral codetections on RSV disease burden in children < 5 years and whether this varies by specific codetected viruses.
Levi Duijst, Valérie Sankatsing, Caterina Rizzo, Francesco Baglivo, Elizabeth Button, Marta Carballal Mariño, María Garcés Sánchez, Christine Hagemann, Simon de Lusignan, Oliver Martyn, Marc Raes, Daan Van Brusselen, Joanne Wildenbeest, Sarah Hak, Foekje Stelma, Jojanneke van Summeren, on behalf of the RSV ComNet network   +16 more
wiley   +1 more source