Results 21 to 30 of about 11,084,010 (163)

Dual‐Functional Silent‐Region SERS Nanoplatform for Real‐Time Bacterial Tracking and Wound Healing Therapy

Advanced Science, EarlyView.
ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng, Rui Wang, Dianqi Zhang, Wei Zhang, Jaebum Choo, Fabiao Yu, Shaowen Cheng   +6 more
wiley   +1 more source

Evaluation of Probiotic Properties and Antimicrobial Substances Produced by Five Lactic Acid Bacteria Against Foodborne and Spoilage Pathogens. [PDF]

Microbiologyopen
ABSTRACT The rise of multidrug‐resistant (MDR) pathogens presents a major challenge to food safety, particularly in preservation approaches. Lactic acid bacteria (LAB) gain probiotic recognition by effectively controlling MDR pathogens using antimicrobial substances (AMSs) and bacteriocin‐like inhibitory substances (BLISs).
Rahman MM, Sazili AQ, Ahmad SA, Khalil KA, Ismail-Fitry MR, Sarker MSK.   +5 more
europepmc   +2 more sources

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Comparision of Colistin Broth Disc Elution, Rapid Resapolymyxin NP and Broth Microdilution Methods in Determining Colistin Sensitivity in Acinetobacter, Pseudomonas and Enterobacterales species

, 2022
© 2022 Ankara Microbiology Society. All rights reserved.In recent years, with the increase of carbapenem resistance in Acinetobacter, Pseudomonas, Enterobacterales species, the use of colistin in treatment has gradually increased.
Mumcuoğlu, İpek, Aksoy, Altan, BARAN, IRMAK, Dinç, Bedia, Irmak Baran, Sarikaya, Ayşenur, Ayşenur Sarıkaya, Altan Aksoy, Bedia Dinç, İpek Mumcuoğlu   +9 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics

Advanced Science, EarlyView.
This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka, Bushra Raahat, Spyros Tragoudas, Hui Li   +3 more
wiley   +1 more source

Evaluation of Spectrophotometric Broth Microdilution Method to Determine the Fluconazole MIC of the Candida Species [PDF]

, 2002
Background :Although the broth microdilution method has been recently established for antifungal susceptibility testing of the Candida species, there is still an argue in the interpretation of the trailing endpoint.
용동은, 이경원
core  

Comparison of Broth Microdilution, Agar Dilution, and Etest for Susceptibility Testing of Doripenem against Gram-Negative and Gram-Positive Pathogens

, 2010
The susceptibility of 513 clinical isolates to doripenem was determined by broth microdilution, agar dilution, and Etest. Overall agreements for Etest and agar dilution MIC values compared to reference broth microdilution at ±1 log 2
R. Flamm, K. Bush, B. Foleno, K. Amsler, C. Santoro   +4 more
core   +1 more source

Diagnosis of bacteraemia in neonatal foals using 16S rRNA high‐throughput sequencing

Equine Veterinary Journal, EarlyView.
Abstract Background Sepsis is an important cause of morbidity and mortality in foals. Early diagnosis can improve outcome but is complicated by non‐specific clinical signs and delayed confirmation of infection via blood culture. Molecular assays represent a rapid and more sensitive alternative.
Flavie Payette, Alicia E. Long, Weiming Hu, Kyle Bittinger, Ahmed M. Moustafa, Darko Stefanovski, Michelle Abraham, Maia R. Aitken   +7 more
wiley   +1 more source

Challenges for interpreting results of antimicrobial susceptibility testing for treating infections of foals with Rhodococcus equi

Equine Veterinary Journal, EarlyView.
Abstract Rhodococcus equi is a facultative intracellular pathogen and a major cause of pneumonia in foals worldwide. The standard treatment for affected foals is a combination of a macrolide with rifampicin. The widespread use of this combination has led to the emergence of multidrug‐resistant (MDR) strains of R. equi.
Marlane Geribone Seeger, Letícia Trevisan Gressler, Laura Huber, Sonsiray Alvarez‐Narvaez, Juliana Felipetto Cargnelutti, Angela Ilha Bordin, Sara D. Lawhon, Noah D. Cohen   +7 more
wiley   +1 more source