Results 41 to 50 of about 37,992 (224)

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Stabilization of tigecycline solutions during susceptibility testing of microorganisms by broth microdilution method

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Tigecycline is widely used in the treatment of infections, leading to the emergence of resistant bacteria. Determining susceptibility by broth microdilution method is recommended to be conducted using freshly prepared Mueller–Hinton broth ...
Irina S. Kosilova, Lyubov V. Domotenko, Mikhail V. Khramov   +2 more
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Susceptibility Testing of Malassezia Species Using the Urea Broth Microdilution Method [PDF]

Antimicrobial Agents and Chemotherapy, 2000
ABSTRACT A urea broth microdilution method to assay the susceptibilities of seven Malassezia species was developed. This method indicated the same sensitivities as the agar plate dilution method for isolates of Malassezia furfur , M. pachydermatis ,
Y, Nakamura, R, Kano, T, Murai, S, Watanabe, A, Hasegawa   +4 more
openaire   +2 more sources

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Discordance of vancomycin minimum inhibitory concentration for methicillin-resistant Staphylococcus aureus at 2 μg/mL between Vitek II, E-test, and Broth Microdilution [PDF]

PeerJ, 2020
Background Vancomycin, the first line antibiotic for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, is often administered inappropriately when MIC is greater than 2 µg/mL, including ‘susceptible’ strains.
Chien-Feng Kuo, Chon Fu Lio, Hsiang-Ting Chen, Yu-Ting Tina Wang, Kevin Sheng-Kai Ma, Yi Ting Chou, Fu-Chieh Chang, Shin-Yi Tsai   +7 more
doaj   +2 more sources

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Incidence, Risk Factors and Susceptibility Prole of Candida species Isolated from Blood of Non-Neutropenic Medical Intensive Care Unit Patients in a Tertiary Care Centre [PDF]

Journal of Krishna Institute of Medical Sciences University, 2016
Background: The critically ill patients are particularly susceptible to rapid colonization by endemic pathogens or hospital ora. Both immunocompetent and immunocompromised patients are particularly exposed to various risk factors.
Vijaya S. Rajmane, V. C. Patil, Shivaji T. Mohite, M. P. Ghatole   +3 more
doaj  

Comparative Evaluation of Disc Diffusion and E-test with Broth Micro-dilution in Susceptibility testing of Amphotericin B, Voriconazole and Caspofungin against Clinical Aspergillus isolates [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background: Clinical importance of Aspergillus has increased over the past few decades because of rise in immunosuppressive drugs and immune-modulating diseases.
Prashant Gupta, Vineeta Khare, Deepak Kumar, Abrar Ahmad, Gopa Banerjee, Mastan Singh   +5 more
doaj   +1 more source

Dual‐Functional Silent‐Region SERS Nanoplatform for Real‐Time Bacterial Tracking and Wound Healing Therapy

Advanced Science, EarlyView.
ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng, Rui Wang, Dianqi Zhang, Wei Zhang, Jaebum Choo, Fabiao Yu, Shaowen Cheng   +6 more
wiley   +1 more source