Results 141 to 150 of about 1,390,341 (404)

Metformin targets brown adipose tissue in vivo and reduces oxygen consumption in vitro

Diabetes, obesity and metabolism, 2018
To test the hypothesis that brown adipose tissue (BAT) is a metformin target tissue by investigating in vivo uptake of [11C]‐metformin tracer in mice and studying in vitro effects of metformin on cultured human brown adipocytes.
P. Breining, J. Jensen, E. Sundelin, L. Gormsen, S. Jakobsen, M. Busk, L. Rolighed, P. Bross, Paula Fernandez-Guerra, Lasse K. Markussen, Nanna E Rasmussen, J. Hansen, S. Pedersen, B. Richelsen, N. Jessen   +14 more
semanticscholar   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science, EarlyView.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
wiley   +1 more source

58 Single-cell comparative analysis reveals a similar regulatory subpopulation in white and brown adipocyte precursors

Journal of Clinical and Translational Science
Objectives/Goals: The goal of this study is to resolve the complexity of the adipose precursor cells and identify potential therapeutic targets/mechanism to treat obesity, diabetes, cancer cachexia, and related metabolic conditions in both white and ...
Hoang Bui, Julia Hansen, Andrea Galmozzi
doaj   +1 more source

Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

Scientific Reports, 2017
Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases has been strongly related to white adipose tissue
M. Alcalá, M. Calderón-Domínguez, Eduviges Bustos, P. Ramos, N. Casals, D. Serra, M. Viana, Laura Herrero   +7 more
semanticscholar   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

Advanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei, Diwen Shou, Siyuan Huang, Yingsi Wang, Quanzhen Liu, Jinfa Liu, Xiaoyu Lv, Yuyi Zeng, Liting Wei, Han Lin, Jiechuan Chen, Yangxiao Chen, Haoyu Zhong, Yanqing Zhou, Wen Ma, Li Wang, Guojun Qian, Jing Guo, Donglin Sun   +18 more
wiley   +1 more source

Histone Deacetylase 3 Prepares Brown Adipose Tissue For Acute Thermogenic Challenge

Nature, 2017
Brown adipose tissue is a thermogenic organ that dissipates chemical energy as heat to protect animals against hypothermia and to counteract metabolic disease.
M. J. Emmett, Hee-Woong Lim, J. Jager, Hannah J Richter, Marine Adlanmerini, Lindsey C Peed, Erika R. Briggs, D. Steger, Tao Ma, C. Sims, J. Baur, Liming Pei, Kyoung-Jae Won, P. Seale, Zachary Gerhart-Hines, M. Lazar   +15 more
semanticscholar   +1 more source

Brown adipose tissue thermogenesis in humans [PDF]

Diabetologia, 2013
The prevalence of obesity and type 2 diabetes is at epidemic proportions. Classical interventions aimed at targeting obesity, such as reducing energy intake or increasing exercise, are often not effective over the long term. In contrast to white adipocytes, which store energy, brown adipocytes generate heat via mitochondrial uncoupling protein 1 ...
openaire   +3 more sources

NRF2‐REGγ‐ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity

Advanced Science, EarlyView.
This study identifies that REGγ is elevated in obese adipose tissue. REGγ modulates WAT browning via ubiquitin‐independent ACADM/KLF15–UCP1 degradation. Overactivation of the NRF2–REGγ axis facilitates adipose tissue function to cause obesity. Inhibition of REGγ in the iWAT alleviates HFD‐induced obesity.
Hui Chen, Qiujing Guan, Shuangming Gong, Yingying Du, Zhidan Zhang, Yan Liu, Lei Zhou, Lin Liu, Baoquan Xin, Yilan Guo, Hui Zhang, Ziyang Zhou, Tongchao Pei, Guohong Yu, Sokun Yin, Lei Li   +15 more
wiley   +1 more source

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, EarlyView.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source

Case report: brown fat accumulation of Tc-99m macroaggregated albumin in a lung perfusion study in a patient with multiple lung arteriovenous malformations and right-to-left shunting [PDF]

, 2015
An 18-year-old man was preoperatively assessed for a varicocele and found to be hypoxemic. A Tc-99m macroaggregated albumin lung perfusion scan showed right-to-left shunting, evidenced by increased radiotracer uptake in the brain, kidneys, thyroid gland,
Marashdeh, Wael, Wahl, Richard L
core   +2 more sources