Results 141 to 150 of about 66,586 (258)

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, EarlyView.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Cancer cachexia induces senescent reprogramming of brown adipose tissue and pro-cachectic S100A9 secretion by adipocytes. [PDF]

Cell Death Dis
Di Biagio C, Tortolici F, Gaudioso F, Ninni A, Giurdanella Annina F, De Ranieri C, Zaccaria F, Sciarretta F, Luca V, Arciprete F, Carotti S, Af de Vries A, Kooijman S, Pacello F, Battistoni A, Lettieri-Barbato D, Aquilano K.   +16 more
europepmc   +1 more source

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

From brown to white: Brown adipose tissue endothelial cells whiten in culture conditions. [PDF]

Mol Metab
Elschner T, Grein S, Sander J, Hildebrand S, Heubach L, Pannwitz N, Mircea M, Raimundez E, Karagiannakou V, Georgiadi A, Heeren J, Hasenauer J, Pfeifer A, Wilhelm-Jüngling K.   +13 more
europepmc   +1 more source

Do Habitat Restoration Efforts and the Associated Releases of Hatchery‐Reared Fish Affect the Genetic Diversity and Integrity of Native Brown Trout Populations?

Fisheries Management and Ecology, EarlyView.
ABSTRACT Habitat restoration may protect brown trout (Salmo trutta) populations from loss of genetic diversity by increasing environmental carrying capacity and, consequently, population size. However, the accompanying release of hatchery‐reared fish may threaten the genetic integrity of native populations through introgression.
Noor Alwash, Ari Huusko, Tuomas Leinonen, Teppo Vehanen, Aki Mäki‐Petäys, Giovanna Mottola, Anssi Vainikka   +6 more
wiley   +1 more source

Single intake of matcha increases brown adipose tissue activity in young women with low thermogenesis. [PDF]

Physiol Rep
Taniguchi H, Hachikawa C, Iwase S, Nirengi S, Nagahata T.   +4 more
europepmc   +1 more source

Dolutegravir population pharmacokinetics in racially, sex‐ and age‐diverse and antiretroviral therapy‐experienced adults with HIV in the United States

HIV Medicine, EarlyView.
Abstract Objectives Dolutegravir (DTG) has been associated with weight gain in women with HIV, Black people with HIV and people with HIV60 years. This study aimed to characterise DTG population pharmacokinetics (PopPK) in a diverse population including these sub‐populations.
Adrian Khoei, Andrew Edmonds, Yen Chang, Catalina Ramirez, Mackenzie Vogan, Amanda Poliseno, Steven Wolinsky, Ken Ho, Todd T. Brown, Joseph B. Margolick, Jacquett Batson, Jennifer Hoffmann, Mark A. Marzinke, Mirjam‐Colette Kempf, Maria L. Alcaide, Joffi Effoe, Cecile D. Lahiri, Igho Ofotokun, Anandi N. Sheth, Stephen Gange, Audrey L. French, Bani Tamraz, Bradley E. Aouizerat, Phyllis C. Tien, Seble G. Kassaye, Jack DeHovitz, Kathryn Anastos, Kara W. Chew, Michelle Floris‐Moore, Julie B. Dumond   +29 more
wiley   +1 more source

Dual Role of Transcription Factors in the Development and Thermogenic Function of Brown Adipose Tissue. [PDF]

Int J Med Sci
Wang S, Xie F, Li W, Xie W, Cheng H.
europepmc   +1 more source

Associations of finerenone with reduced insulin resistance in patients with type 2 diabetes and chronic kidney disease: A real‐world observational study

Journal of Diabetes Investigation, EarlyView.
This real‐world observational study enrolled 256 patients with type 2 diabetes and chronic kidney disease (T2D‐CKD). After 12 months of finerenone treatment, 45 patients completed follow‐up. Finerenone was associated with significant improvements in insulin resistance markers (HOMA‐IR, TyG index), lipid profile (LDL‐C), glycemic control (HbA1c), and ...
Xin Zhao, Bohan Liu, Ran Sun, Yaxuan Shi, Ya Liu   +4 more
wiley   +1 more source

Association of BCAAs/BCKAs with pancreatic steatosis in patients with type 2 diabetes mellitus: A cross‐sectional study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims To examine the association between branched‐chain α‐keto acids (BCKAs) and pancreatic steatosis in patients with type 2 diabetes (T2DM). Methods This cross‐sectional study was conducted from January 2023 to March 2025. Upper abdominal computerized tomography was performed, pancreatic volume (PV), PV index (PVI), CT attenuation of pancreas
Jie Gao, Pijun Cheng, Fusong Jiang, Wenmin Li, Yingying Shi, Wenjun Wang, Liang Wang, Tao Lei, Yunxiang Zang, Jun Lu   +9 more
wiley   +1 more source