Results 151 to 160 of about 172,968 (298)

Brown adipose tissue

Best Practice & Research Clinical Endocrinology & Metabolism, 2016
openaire   +4 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism

Cell Proliferation, EarlyView.
This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang, Juan He, Jing Zheng, Bing Shao, Lixin Shi, Miao Zhang   +5 more
wiley   +1 more source

Cold‐Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Cold exposure activates brown adipose tissue (BAT) and promotes thermogenic and metabolic adaptations. While BAT activation has been linked to improved cardiometabolic health, how acute cold exposure reshapes the circulating lipidome in humans remains incompletely understood.
Yu Zhang, Borja Martinez‐Tellez, Alida Kindt, Nicolas Drouin, Amy Harms, Thomas Hankemeier, Jonatan R. Ruiz, Lucas Jurado‐Fasoli   +7 more
wiley   +1 more source

Periodontal diseases and adverse pregnancy outcomes. Present and future

Periodontology 2000, EarlyView., 2023
Abstract For more than two decades the possible association between periodontal diseases and adverse pregnancy outcomes has been extensively evaluated. Numerous observational, intervention, and mechanistic studies have offered valuable information on this topic.
Yiorgos A. Bobetsis, Mark Ide, Mervi Gürsoy, Phoebus N. Madianos   +3 more
wiley   +1 more source

Deciphering the Presence of Active Interscapular Brown Adipose Tissue in Humans. [PDF]

Acta Physiol (Oxf)
Sanchez-Gomez J, Ruiz-Campos S, Chica-Perez A, Baena-Raya A, Acosta FM, Wolfrum C, Rensen PCN, Romacho T, Martinez-Tellez B.   +8 more
europepmc   +1 more source

Regulation of Peripheral Molecular Clocks in Mammalian Tissues and In Vitro Skeletal Muscle Activation of AMP-Activated Protein Kinase via AICAR

, 2014
Most organisms possess a common molecular machinery that governs cellular and tissue circadian rhythmicity through a roughly 24-hour transcription-translation feedback loop.
Brandauer, Josef, Lupolt, Alex C., Moorhead, Daniel P.   +2 more
core  

Obesity and pony breed are associated with plasma L‐lactate in horses with acute gastrointestinal disease

Equine Veterinary Education, EarlyView.
Summary Background Plasma L‐lactate (lactate) is widely used as a prognostic marker in horses with acute gastrointestinal disease (colic), but association with obesity is unclear. In humans, plasma lactate is correlated with obesity and insulin resistance. Objectives This study aims to evaluate the association of obesity (body condition score ≥7/9) and
A. L. Tillisch, C. Frørup, M. B. Petersen, S. Jacobsen, T. H. Pihl   +4 more
wiley   +1 more source

Fueling or Fighting Cancer? The Thermogenic Paradox of Brown Adipose Tissue. [PDF]

Curr Obes Rep
Guerrero JJG, Encarnacion PC, Wang CH, Del Rosario MAS, Notarte KI, Zhou J, Hsieh YT, Wang WY, Chang CW, Li WC.   +9 more
europepmc   +1 more source