Results 231 to 240 of about 180,287 (345)

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

11-Oxygenated Androgens Inhibit Brown Adipose Tissue Differentiation.

Endocrinology
Yuan Y, Steenbergen J, de Oliveira Santos Goulart A, Sabaté-Pérez A, Visser JA.   +4 more
europepmc   +1 more source

Metabolic signals in sleep regulation: the role of brown adipose tissue. [PDF]

Neurobiol Sleep Circadian Rhythms
Szentirmai É, Kapás L.
europepmc   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue. [PDF]

NPJ Sci Food
Wang S, Lin S, Xie F, Liu S, He T, Chen K, Huang Z, Xie W, Cheng H, Zhang J, Li W.   +10 more
europepmc   +1 more source

Cdkn2a deficiency promotes adipose tissue browning

, 2017
Nabil Rabhi, Sarah Anissa Hannou, Xavier Gromada, Elisabet Salas, Xi Yao, Frédérik Oger, Charlène Carney, Isabel C. López‐Mejía, Emmanuelle Durand, Iandry Rabearivelo, Amélie Bonnefond, Émilie Caron, Lluís Fajas, Christian Dani, Philippe Froguel, Jean‐Sébastien Annicotte   +15 more
openalex   +1 more source

Precision nutrition in weight loss and neuroendocrine control of people with obesity: The study protocol of a factorial randomised controlled trial (GenON Programme)

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Precision nutrition, guided by genetic testing, has emerged as a promising approach for managing obesity. However, robust clinical trials testing its effectiveness in real‐world dietary interventions remain scarce. The GenOn Programme aims to evaluate whether tailoring nutritional care based on genetic risk for obesity enhances weight ...
Karla P. Balbino, Ana Claudia P. Kravchychyn, Flávia G. Cândido, Mariana de Moura e Dias, Tiago Antônio de O. Mendes, Leandro Licursi de Oliveira, Luiza Carla V. Castro, Josefina Bressan, Ana Laura de la Garza, Fermín I. Milagro, María A. Zulet, Helen Hermana M. Hermsdorff   +11 more
wiley   +1 more source

Deletion of MMP12 improves energy metabolism and brown adipose tissue function in mice prone to cardiometabolic disease. [PDF]

J Lipid Res
Amor M, Diaz M, Fuerlinger A, Svecla M, Bianco V, Schooltink L, Dobrijević A, Schwarz B, Akhmetshina A, Vujić N, Korbelius M, Hirtl M, Buerger M, Pirchheim A, Rainer S, Schauer S, Beretta G, Goessler W, Kolb D, Hoefler G, Hackl H, Madreiter-Sokolowski C, Abdellatif M, Norata GD, Kratky D.   +24 more
europepmc   +1 more source

Dual action of imeglimin on insulin secretion and sensitivity in type 2 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Imeglimin is a novel oral hypoglycemic agent approved for the treatment of type 2 diabetes in Japan, with dual actions to enhance insulin secretion and improve insulin sensitivity, suggested by preclinical evidence. However, the effect of imeglimin on tissue‐specific insulin sensitivity and glucose kinetics using glucose tracers is ...
Tsubasa Tajima, Hideyoshi Kaga, Naoaki Ito, Toshiki Kogai, Hitoshi Naito, Saori Kakehi, Satoshi Kadowaki, Yuya Nishida, Ryuzo Kawamori, Yoshifumi Tamura, Hirotaka Watada   +10 more
wiley   +1 more source