Intravitreally injected anti-VEGF antibody reduces brown fat in neonatal mice [PDF]
, 2015 Anti-vascular endothelial growth factor (VEGF) agents are the mainstay treatment for various angiogenesis-related retinal diseases. Currently, bevacizumab, a recombinant humanized anti-VEGF antibody, is trailed in retinopathy of prematurity, a ...
A Hellstrom +40 more
core +10 more sources
Di-san junyi daxue xuebao, 2019 Objective To study the changes in the metabolic activity of brown adipose tissues in a mouse model of progeria using Cerenkov luminescence imaging. Methods 18F-FDG PET/CT imaging and Cerenkov luminescence imaging were used to dynamically monitor the ...
WANG Zhengjie +4 more
doaj +1 more source
Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology [PDF]
, 2016 To view supplementary material for this article, please visit http://dx.doi.org/10.1017/S1751731116000872Both white and brown adipose tissues are recognized to be differently involved in energy metabolism and are also able to secrete a variety of ...
Bonnet, Muriel +3 more
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Human Brown Adipose Tissue [PDF]
Cell Metabolism, 2010 The BAT organ is unique in that it has evolved to safely dissipate large amounts of chemical energy--a quality that might be harnessed to help humans deal with a dangerously hypercaloric environment and still remain in good health.
openaire +3 more sources
Reduced maximum capacity of glycolysis in brown adipose tissue of genetically obese, diabetic (db/db) mice and its restoration following treatment with a thermogenic β-adrenoceptor agonist [PDF]
, 1984 The maximal activities of the key glycolytic enzymes hexokinase and 6-phosphofructokinase, were reduced in brown adipose tissue in db/db mice compared to their lean littermates.
Alison L. Levy +28 more
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Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling [PDF]
, 2015 BACKGROUND: Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT).
Basse, Astrid L. +9 more
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Bioengineering beige adipose tissue therapeutics
Frontiers in Endocrinology, 2015 Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue.
Kevin eTharp, Andreas eStahl
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Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
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Brown vs white adipocytes: The PPARγ coregulator story [PDF]
, 2010 The development of adipose tissue is a process which involves the concerted cooperation of numerous transcription factors together with their coactivators and corepressors.
Kalkhoven, Eric, Koppen, Arjen
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‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk [PDF]
, 2017 Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating ...
Akyol +177 more
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