The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms [PDF]
, 2015 Objectives: The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.
Clark, S. +10 more
core +3 more sources
Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming [PDF]
, 2017 BACKGROUND: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and in
Czech, Michael P +11 more
core +7 more sources
PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]
, 2017 How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M +8 more
core +3 more sources
mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]
, 2016 Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Albert V +12 more
core +4 more sources
Bioengineering beige adipose tissue therapeutics
Frontiers in Endocrinology, 2015 Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue.
Kevin eTharp, Andreas eStahl
doaj +1 more source
miR-34a-/- mice are susceptible to diet-induced obesity [PDF]
, 2016 Objective: MicroRNA (miR)−34a regulates inflammatory pathways, and increased transcripts have been observed in serum and subcutaneous adipose of subjects who have obesity and type 2 diabetes.
Baker, Andrew H. +7 more
core +1 more source
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
doaj +1 more source
Characterisation of human adipose tissue : ceramide metabolism, depot differences and evaluation of dysfunctionality [PDF]
, 2016 Normal adipose tissue function is necessary for maintaining proper energy balance, as both excess and absence of this tissue lead to metabolic disturbances, such as insulin resistance.
Gertow, Joanna
core +1 more source
Resveratrol and Pterostilbene, Two Analogue Phenolic Compounds, Affect Aquaglyceroporin Expression in a Different Manner in Adipose Tissue [PDF]
, 2018 Aquaglyceroporins (AQPs) are transmembrane channels that mediate glycerol release and glycerol uptake. They are involved in fat metabolism, with implications in obesity. The aim was to determine whether the administration of resveratrol and pterostilbene
Fernández Quintela, Alfredo +4 more
core +2 more sources
Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling [PDF]
, 2015 BACKGROUND: Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT).
Basse, Astrid L. +9 more
core +3 more sources