Results 31 to 40 of about 1,970,039 (250)
Cell Reports, 2018 Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved.
David Lasar +18 more
doaj +1 more source
Indomethacin Enhances Brown Fat Activity [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2018 Indomethacin, a nonsteroidal anti-inflammatory drug, has been shown to induce white adipocyte differentiation; however, its roles in brown adipocyte differentiation and activation in brown adipose tissue (BAT) and obesity are unknown. To address this issue, we treated mouse brown preadipocytes with different doses of indomethacin, and delivered ...
Hao, Lei +9 more
openaire +4 more sources
Enhancing brown fat with NFIA [PDF]
Nature Cell Biology, 2017 Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.
Suzanne N, Shapira, Patrick, Seale
openaire +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Mirabegron as a β3-adrenoceptor agonist is a routinely prescribed drug for treating overactive bladder syndrome. However, the effect of this drug on off-targeted tissues and organs is largely unknown.
Wenhai Sui +17 more
semanticscholar +1 more source
Heliyon, 2023 Background: Bone marrow mesenchymal stem cells (BMMSCs) possess the ability of adipogenic differentiation. Icariin (ICA) is a prenylated flavonol glycoside with diverse pharmacological activities and has been reported to promote osteogenic ...
Yao Lu +7 more
doaj +1 more source
Ginsenoside Rb2 Alleviates Obesity by Activation of Brown Fat and Induction of Browning of White Fat
Frontiers in Endocrinology, 2019 Ginsenoside Rb2 (Rb2), the most abundant saponin contained in Panax ginseng, has been used to treat variety of metabolic diseases. However, its effects in obesity and potential mechanisms are not well-understood.
Yilian Hong +5 more
semanticscholar +1 more source
Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis
Nature Metabolism, 2019 Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process is poorly understood. Here, we identify mitochondrial lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Kazuki Tajima +9 more
semanticscholar +1 more source
Scientific Reports, 2022 Beige and brown fat consume glucose and lipids to produce heat, using uncoupling protein 1 (UCP1). It is thought that full activation of brown adipose tissue (BAT) may increase total daily energy expenditure by 20%.
Mojgan Nazari +10 more
doaj +1 more source
Brown Fat Promotes Muscle Growth During Regeneration
Journal of Orthopaedic Research, 2019 Accumulation of adipose tissue around and within muscles is highly correlated with reduced strength, functional limitations, and poor rehabilitative outcomes.
Anna Bryniarski, G. Meyer
semanticscholar +1 more source
Role of energy metabolism in the brown fat gene program
Frontiers in Endocrinology, 2015 In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes.
Minwoo eNam, Marcus eCooper
doaj +1 more source