Results 51 to 60 of about 1,970,039 (250)
Experimental and Molecular Medicine, 2019 Fat tissue disorders: Dysfunctional fat cell differentiation An abnormal distribution of fatty tissues associated with certain tissue disorders is driven by disrupted fat cell differentiation.
Camilla Pellegrini +17 more
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BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
Nature Communications, 2020 The regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin ...
Tongyu Liu +10 more
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Science-Business eXchange, 2010 German researchers have identified a COX-2–mediated pathway in mice that could trigger weight loss. To use this to treat obesity, the challenge would be to develop compounds that boost activity of the pathway in adipose tissue without increasing COX-2–related inflammation.
openaire +1 more source
FAT TISSUE DISTRIBUTION BETWEEN SUBCUTANEOUS AND INTERMUSCULAR FAT TISSUE IN SIMMENTAL AND BROWN BULLS [PDF]
Poljoprivreda, 2007 Simmental and Brown bulls from progeny testing station were used to evaluate the effect of breed on fat tissue partition between subcutaneous and intermuscular fat.
S. Žgur, M. Čepon
doaj
RalA controls glucose homeostasis by regulating glucose uptake in brown fat
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance The primary event in diabetes pathogenesis is the development of insulin resistance. Insulin is elevated during feeding and maintains blood glucose levels within a physiological range, largely by increasing glucose uptake in muscle and fat ...
Y. Skorobogatko +15 more
semanticscholar +1 more source
PLoS ONE, 2015 Brown fat generates heat to protect against cold and obesity. Adrenergic stimulation activates the thermogenic program of brown adipocytes. Although the bioactivity of brown adipose tissue in adult humans had been assumed to very low, several studies ...
Gaku Nagano +6 more
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Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat
Cell Reports, 2017 Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic function of
Lu Yao +8 more
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The significance of beige and brown fat in humans
Endocrine Connections, 2017 Promotion of brown adipose tissue (BAT) activity or browning of white adipose tissue has shown great potential as anti-obesity strategy in numerous preclinical models.
F. Kiefer
semanticscholar +1 more source
Essential role for miR-196a in brown adipogenesis of white fat progenitor cells.
PLoS Biology, 2012 The recent discovery of functional brown adipocytes in adult humans illuminates the potential of these cells in the treatment of obesity and its associated diseases. In rodents, brown adipocyte-like cells are known to be recruited in white adipose tissue
Masaki Mori +4 more
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Brown Algae Polyphenol, a Prolyl Isomerase Pin1 Inhibitor, Prevents Obesity by Inhibiting the Differentiation of Stem Cells into Adipocytes. [PDF]
PLoS ONE, 2016 While screening for an inhibitor of the peptidyl prolyl cis/trans isomerase, Pin1, we came across a brown algae polyphenol that blocks the differentiation of fibroblasts into adipocytes.
Atsuko Suzuki +4 more
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