Results 71 to 80 of about 102,830 (343)

Several mechanisms drive the heterogeneity in browning across a boreal stream network [PDF]

open access: gold, 2023
Xudan Zhu   +5 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Integrated Metabolomic and Transcriptomic Analyses Reveal the Potential Molecular Mechanism Underlying Callus Browning in Paeonia ostii

open access: yesPlants
Callus browning is a significant problem that hinders plant tissue regeneration in Paeonia ostii “Fengdan” by causing cell death and inhibiting growth. However, the molecular mechanism underlying callus browning in P. ostii remains unclear. In this study,
Xiaohui Wen   +6 more
doaj   +1 more source

Soft X-ray emission in kink-unstable coronal loops [PDF]

open access: yes, 2014
Solar flares are associated with intense soft X-ray emission generated by the hot flaring plasma. Kink unstable twisted flux-ropes provide a source of magnetic energy which can be released impulsively and account for the flare plasma heating.
Brun, A. S., Pinto, R. F., Vilmer, N.
core   +5 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Brown adipocyte and browning thermogenesis: metabolic crosstalk beyond mitochondrial limits and physiological impacts

open access: yesAdipocyte, 2023
Brown adipocytes were proposed to reverse metabolic conditions such as obesity and diabetes, which make them potential for therapeutic applications.
Van Thi-Tuong Nguyen   +2 more
doaj   +1 more source

Solar convection zone dynamics

open access: yes, 2010
A comprehensive understanding of the solar magnetic cycle requires detailed modeling of the solar interior including the maintenance and variation of large scale flows (differential rotation and meridional flow), the solar dynamo and the flux emergence ...
Rempel, M.
core   +1 more source

Magnetic Inhibition of Convection and the Fundamental Properties of Low-Mass Stars. II. Fully Convective Main Sequence Stars [PDF]

open access: yes, 2014
We examine the hypothesis that magnetic fields are inflating the radii of fully convective main sequence stars in detached eclipsing binaries (DEBs). The magnetic Dartmouth stellar evolution code is used to analyze two systems in particular: Kepler-16 ...
Chaboyer, Brian, Feiden, Gregory A.
core   +3 more sources

Metabolomics and Transcriptomics unravel the mechanism of browning resistance in Agaricus bisporus [PDF]

open access: green, 2021
Zhongshun Cai   +6 more
openalex   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

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