Results 1 to 10 of about 39,292 (166)
Coenzyme A binding sites induce proximal acylation across protein families
Scientific Reports, 2023 Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications that regulate protein function. In mitochondria, lysine acylation is predominantly non-enzymatic, and only a specific subset of the proteome is acylated ...
Chris Carrico +8 more
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A role for worm cutl-24 in background- and parent-of-origin-dependent ER stress resistance
BMC Genomics, 2022 Background Organisms in the wild can acquire disease- and stress-resistance traits that outstrip the programs endogenous to humans. Finding the molecular basis of such natural resistance characters is a key goal of evolutionary genetics.
Wenke Wang +4 more
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Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs
JBMR Plus, 2021 Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age‐related disease and improve the quality of life.
Daniel S Evans +24 more
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Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types
iScience, 2022 Summary: Cellular senescence is a driver of many age-related pathologies. There is an active search for pharmaceuticals termed senolytics that can mitigate or remove senescent cells in vivo by targeting genes that promote the survival of senescent cells.
Chandani Limbad +9 more
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Nature Communications, 2022 Circadian dysfunction is a potential driver of eye aging. Here the authors report that in conjunction with the core molecular clock transcription factor Clock, dietary restriction promotes rhythmic homeostatic mechanisms within photoreceptors to delay ...
Brian A. Hodge +12 more
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CD38 regulates ovarian function and fecundity via NAD+ metabolism
iScience, 2023 Summary: Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show that
Rosalba Perrone +17 more
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A novel splice variant of Elp3/Kat9 regulates mitochondrial tRNA modification and function
Scientific Reports, 2022 Post-translational modifications, such as lysine acetylation, regulate the activity of diverse proteins across many cellular compartments. Protein deacetylation in mitochondria is catalyzed by the enzymatic activity of the NAD+-dependent deacetylase ...
Rachid Boutoual +11 more
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A Fault-Tolerant DC-DC Converter with Zero Interruption Time Using Capacitor Health Prognosis
International Journal of Prognostics and Health Management, 2023 A high-end critical electronic system is expected to have hundreds of electronic subsystems, which rely on the Power Management Unit (PMU) to be energized.
Preethi Sharma K, Vijayakumar T
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Stem Cell Reports, 2015 In this study, we used patient-specific and isogenic PARK2-induced pluripotent stem cells (iPSCs) to show that mutations in PARK2 alter neuronal proliferation.
Atossa Shaltouki +6 more
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Conservation of Buck’s Spermatozoa during Cooling Storage Period through Cooling Medium Supplementation with L-Carnitine [PDF]
Archives of Razi Institute, 2021 This research examined the influence of the addition of L-carnitine (LC) to cooling medium on buck’s semen quality during cooling storage periods at 4oC.
M Heydari +4 more
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