Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression [PDF]
Advanced ScienceBreast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects.
Siyu Guo +15 more
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Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha [PDF]
Nature CommunicationsTarget identification in natural products plays a critical role in the development of innovative drugs. Bufalin, a compound derived from traditional medicines, has shown promising anti-cancer activity; however, its precise molecular mechanism of action ...
Shilong Jiang +12 more
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Bufalin-Loaded Multifunctional Nanodrugs for Cancer Therapy: Mechanisms, Delivery Strategies, and Translational Perspectives [PDF]
BiomoleculesBufalin is a naturally occurring bufadienolide with broad-spectrum anticancer activity. Unlike conventional cytotoxic agents, bufalin exerts pleiotropic antitumour effects by directly modulating oncogenic proteins and promoting their degradation. It also
Yanrui Yang +7 more
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Bufalin post-transcriptionally suppresses STAT3 to alleviate renal ferroptosis and tubulointerstitial fibrosis in diabetic kidney disease [PDF]
Renal FailureThe pathological hallmark of diabetic kidney disease (DKD) is tubulointerstitial fibrosis (TIF), which arises from extracellular matrix (ECM) synthesis in renal tubular epithelial cells (RTECs).
Yunyang Qiao +9 more
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Bufalin targets E2F2 to transcriptionally inhibit LINC01410 and suppress Wnt/β-catenin signaling in esophageal squamous cell carcinoma [PDF]
npj Precision OncologyBufalin, a main active monomer component extracted from the Traditional Chinese Medicine toad venom, exhibits potent anti-tumour activity across diverse malignancies.
Xiaohong Kang +14 more
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Bufalin Suppresses Colorectal Cancer Liver Metastasis by Inhibiting De Novo Fatty Acid Synthesis via the PI3K/AKT-Mediated SREBP1/FASN Pathway [PDF]
MoleculesBackground: Colorectal cancer (CRC) is the third most common cancer worldwide, with liver metastasis being the leading cause of mortality. De novo fatty acid synthesis plays a critical role in CRC progression and metastasis.
Wenwen Pang +7 more
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Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple‐Negative Breast Cancer [PDF]
Advanced ScienceIdentifying novel therapeutic targets and drugs is crucial for treating triple‐negative breast cancer (TNBC). Bufalin, a key active ingredient of the traditional Chinese medicine HuaChansu, has been employed in tumor therapy.
Shilong Jiang +11 more
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Bufalin targets the SRC-3/c-Myc pathway in chemoresistant cells to regulate metastasis induced by chemoresistance in colorectal cancer [PDF]
Journal of Cancer Research and Clinical OncologyBackground Metastasis and chemoresistance are often major challenges in advanced-stage colorectal cancer. Bufalin has a therapeutic effect on both metastasis and drug resistance, but how bufalin affects chemoresistance-mediated metastasis remains unclear.
Jinbao Chen +10 more
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Effect of Bufalin-PLGA Microspheres in the Alleviation of Neuropathic Pain via the CCI Model
Frontiers in Pharmacology, 2022 The treatment of neuropathic pain (NPP) is considered challenging, while the search for alternative medication is striving. NPP pathology is related with the expression of both the purinergic 2X7 (P2X7) receptor and the transient receptor potential ...
Lina Long +9 more
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Bufalin suppresses ovarian cancer cell proliferation via EGFR pathway
Chinese Medical Journal, 2022 . Background:. Previous studies have shown that bufalin exerts antitumor effects through various mechanisms. This study aimed to determine the antineoplastic mechanism of bufalin, an extract of traditional Chinese medicine toad venom, in ovarian cancer ...
Lei Dou +7 more
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