Results 41 to 50 of about 2,051 (160)
Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.We present a novel convergent strategy that integrates Pd/Ag‐promoted Suzuki–Miyaura coupling with Ir‐catalyzed radical‐relay cyclization, enabling the first total synthesis of 16β‐hydroxylpseudobufarenogin. This approach is broadly applicable to the total synthesis of various oxygenated bufadienolides by simply modifying the fragment structures ...
Wataru Shigematsu +3 more
wiley +2 more sources
Journal of Experimental & Clinical Cancer Research, 2022 Background Currently, multiple myeloma (MM) is still an incurable plasma cell malignancy in urgent need of novel therapeutic targets and drugs. Methods Bufalin was known as a highly toxic but effective anti-cancer compound.
Chunyan Gu +16 more
doaj +1 more source
Molecules, 2022 Toad venom, a dried product of secretion from Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider, has had the therapeutic effects of hepatocellular carcinoma confirmed.
Pan Liang +9 more
doaj +1 more source
Next‐Generation Pluronic Micelles for Advanced Drug Delivery Application
Macromolecular Materials and Engineering, Volume 311, Issue 9, September 2026.The present review provides a comprehensive overview of Pluronic‐based micelles for advanced drug and gene delivery. It highlights their structure, classification, synthesis, self‐assembly, and functionalization, as well as their biocompatibility and stimuli‐responsive properties.
Manoj Gundeti +6 more
wiley +1 more source
Bufalin exhibited strong anti-osteosarcoma activity in vivo.
, 2013 Mice with U-2OS/MTX300 xenografts were treated with bufalin, MTX or vehicle control (n = 6). (A) Bufalin-treated mice exhibited slower tumor growth. (B) A significantly decreased tumor weight at study termination, as compared to control or MTX-treated ...
Jing-nan Shen (302702) +11 more
core +1 more source
, 2020 Bufalin is a cardiotonic steroid and a key active ingredient of the Chinese medicine ChanSu. It has significant anti-tumor activity against many malignancies, including hepatocellular carcinoma (HCC). Previous studies have shown that human bodies contain
Geliang Yang (8347641) +5 more
core +1 more source
Molecules, 2017 Bone cancer is one of the cancer-related diseases, and there are increased numbers of patients with bone cancer worldwide. Therefore the efficacy of treatment of bone cancer is considered extremely vital.
Ching-Hsiao Lee +6 more
doaj +1 more source
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.Dual‐drug‐loaded liposomes enable the simultaneous delivery of hydrophilic and hydrophobic therapeutics to tumors, enhancing anticancer efficacy and overcoming multidrug resistance. Through rational formulation design and surface functionalization, these systems improve tumor targeting, modulate efflux mechanisms and EMT, and achieve synergistic ...
Neelam Sinha +4 more
wiley +1 more source
Bufalin exerted potent anti-osteosarcoma activity in vitro.
, 2013 (A) Bufalin induced a dose- and time-dependent decrease in osteosarcoma cell growth. (B) Bufalin treatment resulted in G2/M cell cycle arrest in osteosarcoma cell lines (PI staining and FACS analysis).
Jing-nan Shen (302702) +11 more
core +1 more source
, 2020 Bufalin is a cardiotonic steroid and a key active ingredient of the Chinese medicine ChanSu. It has significant anti-tumor activity against many malignancies, including hepatocellular carcinoma (HCC). Previous studies have shown that human bodies contain
Geliang Yang (8347641) +5 more
core +1 more source