Results 61 to 70 of about 2,051 (160)

Supramolecular Coordination Platforms for Smart Theranostics: Leveraging the Dynamic Molecular Networks of Metal–Polyphenol Assemblies

Aggregate, Volume 7, Issue 7, July 2026.
In this review, we summarize the recent developments of metal–polyphenol networks (MPNs) as a highly versatile and functionally integrated supramolecular assembly platform. We also discuss their pivotal role in steering biomedical materials away from conventional single‐function designs and toward intelligent, unified diagnostic and therapeutic ...
Kang Zhu, Minjing Guo, Wenping Li, Xiaoyu Zhang, Ling Chen, Jibin Song   +5 more
wiley   +1 more source

Synthetic scheme of 3-phospho-bufalin.

, 2015
Synthetic scheme of 3-phospho-bufalin.
Mingkun Zhao (803007), Xing Liu (221084), Feng Li (30515), Jianwei Chen (281404), Chengwei Zhang (573927), Jianming Xu (15308), Xiaosong Wang (14022), Hui Chen (28597), David M. Lonard (554019), Xianzhou Song (803006), Bert W. O’Malley (63322), Jin Wang (29560), Li Qin (205731)   +12 more
core   +1 more source

Bufalin Inhibits Cellular Proliferation and Cancer Stem Cell-Like Phenotypes via Upregulation of MiR-203 in Glioma

Cellular Physiology and Biochemistry, 2017
Background/Aims: Prior studies have shown that bufalin inhibits cellular proliferation and induces apoptosis in various human cancers. MicroRNA-203 (miR-203) has been shown to function as an important regulator of tumor progression at various stages.
Tao Liu, Chanji Wu, Guohu Weng, Zhongyan Zhao, Xiangying He, Chuanyi Fu, Zhiyan Sui, Shi-Xiong Huang   +7 more
doaj   +1 more source

Reverse Thermo‐Responsive Nanoshells: The Interplay Between the Composition of Their Building Blocks and Their Temperature‐Responsive Morphing

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
The graphical abstract shows hollow polymeric nanoshells from crosslinked PEO–PPO–PEO with methacrylate end‐groups. These shells expand at low temperatures (6 °C, ∼310 nm) and shrink at 37 °C (∼35 nm)—a 700‐fold volume change. This reverse thermo‐responsiveness, driven by polymer coiling–uncoiling, enables potential biomedical applications like ...
Mark David Samraj, Rajdip Roy, Gilad Lando, Daniel Cohn   +3 more
wiley   +1 more source

New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin

Cancer Cell International, 2019
Aim of the review In the past decade, increasing research attention investigated the novel therapeutic potential of steroidal cardiac glycosides in cancer treatment.
Chien-shan Cheng, Jiaqiang Wang, Jie Chen, Kuei Ting Kuo, Jian Tang, Huifeng Gao, Lianyu Chen, Zhen Chen, Zhiqiang Meng   +8 more
doaj   +1 more source

Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. [PDF]

PLoS ONE, 2015
Triple negative breast cancer (TNBC) has the poorest prognosis of all types of breast cancer and currently lacks efficient targeted therapy. Chemotherapy is the traditional standard-of-care for TNBC, but is frequently accompanied by severe side effects ...
Xianzhou Song, Chengwei Zhang, Mingkun Zhao, Hui Chen, Xing Liu, Jianwei Chen, David M Lonard, Li Qin, Jianming Xu, Xiaosong Wang, Feng Li, Bert W O'Malley, Jin Wang   +12 more
doaj   +1 more source

Traditional Chinese medicine bufalin inhibits infectious hematopoietic necrosis virus infection in vitro and in vivo

Microbiology Spectrum
Infectious hematopoietic necrosis virus (IHNV) causes infectious hematopoietic necrosis and severe economic losses to salmon and trout aquaculture worldwide.
Jing-Zhuang Zhao, Li-Ming Xu, Lin-Fang Li, Guang-Ming Ren, Yi-Zhi Shao, Qi Liu, Tong-Yan Lu   +6 more
doaj   +1 more source

Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways

Gastroenterology Research and Practice, 2015
Aims. To investigate the anticolorectal cancer (CRC) effects of Bufalin, a bioactive polyhydroxysteroid from Venenum Bufonis, using HCT116 human CRC cell and an established orthotopic xenograft model in mice, and to explore the mechanisms of action ...
Jie Wang, Chao Chen, Shiying Wang, Yong Zhang, Peihao Yin, Zhongxiang Gao, Jie Xu, Dianxu Feng, Qinsong Zuo, Ronghua Zhao, Teng Chen   +10 more
doaj   +1 more source

Vitamin D receptor signaling in inflammatory senescence–associated skin aging: Mechanisms and therapeutic potentials

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Vitamin D receptor (VDR) signaling is implicated in inflammatory senescence‐associated skin aging, a growing health concern in aging populations where cellular senescence and chronic inflammation converge to create complex pathophysiological conditions.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source