Results 71 to 80 of about 2,051 (160)
Bufalin-induced Akt inactivation is IRE1 dependent.
, 2015 (A) Huh7 cells were exposed to 100 nM bufalin for 12, 24, or 48 h. Untreated cells served as controls. Cell lysates were immunoblotted, and the density of each band was measured. Band densities were normalized to β-actin.
Xueying Sun (201047) +8 more
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Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen +3 more
wiley +1 more source
, 2001 Bufalin, an Na+-K+-ATPase inhibitor, simultaneously induced cell differentiation and apoptosis in human monocytic leukemia THP-1 cells. In this study, we investigated the regulatory role of protein kinase C (PKC) isozymes in bufalin-induced cell ...
Takemi Yoshida +4 more
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Integrative Cancer TherapiesChemoresistance is still an important factor affecting the efficacy of treatment in colorectal cancer (CRC) patients. Hypoxia is related to poor prognosis and treatment resistance in cancer. Relevant studies have shown that a hypoxic microenvironment can
Haijing Wang MD +6 more
doaj +1 more source
, 2012 Peihao Yin,1,* Yan Wang,1,* YanYan Qiu,1 LiLi Hou,1 Xuan Liu,1 Jianmin Qin,1 Yourong Duan,2 Peifeng Liu,2 Ming Qiu,3 Qi Li11Department of Clinical Oncology, Putuo Hospital and Interventional Cancer Institute of Integrative Medicine, Shanghai University ...
Liu X +9 more
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Reversal effect of bufalin on multidrug resistance in K562/VCR vincristine-resistant leukemia cell line [PDF]
, 2014 ObjectiveTo probe insights into the reversal effect of bufalin on vincristine-acquired multidrug resistance (MDR) in human leukemia cell line K562/VCR.MethodsProliferative inhibition rate and the reversal index (RI) of bufalin were determined by Methyl ...
Lu, Jianying +11 more
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, 2019 Glioma is the most common malignant tumor of the central nervous system, and it is characterized by high relapse and fatality rates and poor prognosis. Bufalin is one of the main ingredients of Chan-su, a traditional Chinese medicine (TCM) extracted from
Yi Chen +14 more
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Cellular Physiology and Biochemistry, 2015 Background/Aims: Osteosarcoma (OS) is the second leading cause of cancer-related death in children and young adults. Chemoresistance is the most important cause of treatment failure in OS, largely resulting from presence of cancer stem cells (CSCs ...
Yuewen Chang +6 more
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Bufalin modifies the endogenous level of Hsp27 and its relevant molecules.
, 2013 (A) The level of Hsp27 in U-2OS and U-2OS/MTX300 cells were detected by Western blot after bufalin treatment. (B) Following incubation with bufalin for 48 h, the level of Hsp27 mRNA was examined by RT-PCR analysis.
Jing-nan Shen (302702) +11 more
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OncoImmunology, 2018 The Toll-like receptor 3 (TLR3) agonists as polyriboinosinic–polyribocytidylic acid (poly (I:C)) have been implicated as potential immunotherapy adjuvant for cancer whereas the exact roles of TLR3 agonists in hepatocellular carcinoma (HCC) treatment have
Yinglu Feng +6 more
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