Results 51 to 60 of about 2,051 (160)
Pharmaceutics, 2021 Cardiotonic steroids are steroid-like natural compounds known to inhibit Na+/K+-ATPase pumps. To develop a broad-spectrum antiviral drug against the emerging coronavirus infection, this study assessed the antiviral properties of these compounds.
Young-Hee Jin +8 more
doaj +1 more source
MedComm, Volume 7, Issue 9, September 2026.This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng +9 more
wiley +1 more source
Bufalin suppresses endometriosis progression by inducing pyroptosis and apoptosis
, 2018 The steroid receptor coactivator (SRC)-1 isoform/estrogen receptor (ER)-β axis has an essential role in endometriosis progression. In this context, therefore, bufalin was employed as a ‘tool compound’ to evaluate inhibitors of SRC in alternative ...
Sang Jun Han +4 more
core +1 more source
Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Precision Medical Sciences, Volume 15, Issue 3, Page 206-226, September 2026.Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley +1 more source
Bufalin synergizes with sorafenib to inhibit HCC cell growth.
, 2015 (A) HepG2 and Huh7 cells were exposed to different concentrations of bufalin and/or sorafenib for 48 h. (B) The above cells were incubated with 100 nM bufalin and/or 5 μM sorafenib for different periods.
Xueying Sun (201047) +8 more
core +1 more source
Breaking Physiological Barriers in Women's Health: Mucoadhesive and Stimuli‐Responsive Nanomaterials
WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 5, September/October 2026.Drug delivery vehicles generated from biomaterials for women's health. In particular, the breast and the reproductive system, including the ovary, uterus, cervix, vagina, and the surrounding tissues, targeted drug delivery. BioRender. ABSTRACT Biomaterials are natural or synthetic molecules that exhibit biocompatibility, biodegradability, or ...
Maddox Parsons +4 more
wiley +1 more source
Bufalin inhibits MM cells proliferation.
, 2013 (A–D) Cells were seeded in 96-well plates and treated with different concentrations of bufalin for 12, 24 and 48 h. Bufalin-induced effects on cell proliferation were measured by CCK8 assay. All values represent means ± S.D.
He Huang (50693) +8 more
core +1 more source
Advanced Science, Volume 13, Issue 46, 17 August 2026.SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng +18 more
wiley +1 more source
, 2022 The treatment of neuropathic pain (NPP) is considered challenging, while the search for alternative medication is striving. NPP pathology is related with the expression of both the purinergic 2X7 (P2X7) receptor and the transient receptor potential ...
Liwei Guo (1424869) +4 more
core +1 more source
Autophagy Modulation in Cancer Therapy: Navigating the Dual Roles to Overcome Chemoresistance
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background Autophagy is a fundamental cellular recycling mechanism with complex and often opposing roles in cancer, functioning as both a tumor suppressor and a pro‐survival mechanism in established tumors. This duality has attracted considerable attention, particularly regarding the therapeutic modulation of autophagy to overcome ...
Md Mohiuddin, Md Al Mamun Ahsan
wiley +1 more source