Results 1 to 10 of about 126,969 (147)

Evaluation of Anti-Inflammatory Activity of the New Cardiotonic Steroid γ-Benzylidene Digoxin 8 (BD-8) in Mice [PDF]

Cells
Cardiotonic steroids are known to bind to Na+/K+-ATPase and regulate several biological processes, including the immune response. The synthetic cardiotonic steroid γ-Benzylidene Digoxin 8 (BD-8) is emerging as a promising immunomodulatory molecule ...
Davi Azevedo Ferreira, Anna Beatriz Araujo Medeiros, Mariana Mendonça Soares, Éssia de Almeida Lima, Gabriela Carolina Santos Lima de Oliveira, Mateus Bernardo da Silva Leite, Matheus Vieira Machado, José Augusto Ferreira Perez Villar, Leandro Augusto Barbosa, Cristoforo Scavone, Marcelo Tigre Moura, Sandra Rodrigues-Mascarenhas   +11 more
doaj   +3 more sources

Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads †

Molecules, 2022
Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000 years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of amphibians and toads and can also be extracted from natural products such ...
shaymaa Mahmoud, Ahmed Zayed, Ming Du
exaly   +4 more sources

Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus Infections

Pharmaceutics, 2021
Cardiotonic steroids are steroid-like natural compounds known to inhibit Na+/K+-ATPase pumps. To develop a broad-spectrum antiviral drug against the emerging coronavirus infection, this study assessed the antiviral properties of these compounds.
Young-Hee Jin, Min Seong Jang, Sunoh Kwon   +2 more
exaly   +4 more sources

Evaluation of the Anti-Mycobacterial and Anti-Inflammatory Activities of the New Cardiotonic Steroid γ-Benzylidene Digoxin-15 in Macrophage Models of Infection [PDF]

Microorganisms
Cardiotonic steroids modulate various aspects of the inflammatory response. The synthetic cardiotonic steroid γ-benzylidene digoxin 15 (BD-15), a digoxin derivative, has emerged as a promising candidate with potential immunomodulatory effects.
Daniel Wilson A. Magalhães, Maria Gabriella S. Sidrônio, Noêmia N. A. Nogueira, Deyse Cristina Madruga Carvalho, Maria Eugênia G. de Freitas, Ericke Cardoso Oliveira, Gustavo F. de Frazao Lima, Demétrius A. M. de Araújo, Cristoforo Scavone, Thalisson Amorim de Souza, José Augusto F. P. Villar, Leandro A. Barbosa, Francisco Jaime Bezerra Mendonça-Junior, Valnês S. Rodrigues-Junior, Sandra Rodrigues-Mascarenhas   +14 more
doaj   +3 more sources

Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain [PDF]

Frontiers in Physiology, 2017
Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described.
Luiz H. A. Cavalcante-Silva, Éssia de Almeida Lima, Deyse C. M. Carvalho, José M. de Sales-Neto, Anne K. de Abreu Alves, José G. F. M. Galvão, Juliane S. de França da Silva, Sandra Rodrigues-Mascarenhas, Sandra Rodrigues-Mascarenhas, Sandra Rodrigues-Mascarenhas   +9 more
doaj   +3 more sources

Ca²⁺-Driven Selectivity of the Effect of the Cardiotonic Steroid Marinobufagenin on Rabbit Sinoatrial Node Function [PDF]

Cells, 2023
The synergy between Na+-K+ pumps, Na+-Ca2+ exchangers, membrane currents and the sarcoplasmic reticulum (SR) generates the coupled-clock system, which governs the spontaneous electrical activity of heart sinoatrial node cells (SANCs).
Sofia Segal, Yael Yaniv
doaj   +2 more sources

The endogenous cardiotonic steroid Marinobufagenin and decline in estimated glomerular filtration rate at follow-up in patients with arterial hypertension. [PDF]

PLoS ONE, 2019
BackgroundMarinobufagenin (MBG) is an endogenous cardiotonic steroid (CTS) that inhibits the Na+/K+-ATPase. Human MBG is significantly increased in end-stage renal disease and immunization against MBG attenuates cardiovascular fibrosis in a rat model of ...
Martin H Keppel, Grzegorz Piecha, Winfried März, Janne Cadamuro, Simon Auer, Thomas K Felder, Cornelia Mrazek, Hannes Oberkofler, Christian Trummer, Martin R Grübler, Verena Schwetz, Nicolas Verheyen, Marlene Pandis, Valentin Borzan, Elisabeth Haschke-Becher, Andreas Tomaschitz, Stefan Pilz   +16 more
doaj   +2 more sources

From hormonal immunomodulation to glioblastoma therapy: the emerging role of Ouabain [PDF]

Frontiers in Immunology
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, characterized by rapid proliferation, diffuse infiltration, and resistance to conventional therapies.
Arthur Gomes de Andrade, Deyse Cristina Madruga Carvalho, Daniel Wilson Arruda Magalhaes, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira, Sandra Rodrigues-Mascarenas, Luiz Henrique Agra Cavalcante-Silva, Luiz Henrique Agra Cavalcante-Silva   +7 more
doaj   +2 more sources

Evolutionary insights into Na+/K+-ATPase-mediated toxin resistance in the Crested Serpent-eagle preying on introduced cane toads in Okinawa, Japan [PDF]

BMC Ecology and Evolution
Prey species often develop toxic chemical defenses against predators, prompting predators to evolve traits that counteract these toxins. A prime example of this evolutionary arms race involves resistance to lethal cardiotonic steroids, which is ...
Alisa Tobe, Yu Sato, Mitsuki Kondo, Manabu Onuma, Miho Inoue-Murayama   +4 more
doaj   +2 more sources

Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na+/K+‐ATPase‐α‐1

Journal of the American Heart Association, 2020
Background Recent studies have highlighted a critical role for a group of natriuretic hormones, cardiotonic steroid (CTS), in mediating renal inflammation and fibrosis associated with volume expanded settings, such as chronic kidney disease.
David J Kennedy, Yiliang Chen, Fatimah K Khalaf   +2 more
exaly   +3 more sources