Results 11 to 20 of about 126,969 (147)

Na⁺,K⁺-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies

Biomedicines, 2023
In recent years, enough evidence has accumulated to assert that cardiotonic steroids, Na+,K+-ATPase ligands, play an integral role in the physiological and pathophysiological processes in the body.
Alisa A. Markina, Rogneda B. Kazanskaya, Julia A. Timoshina, Vladislav A. Zavialov, Denis A. Abaimov, Anna B. Volnova, Tatiana N. Fedorova, Raul R. Gainetdinov, Alexander V. Lopachev   +8 more
doaj   +2 more sources

Ouabain exerts protective effects on SH-SY5Y cells upon Zika virus infection [PDF]

Virology Journal
Zika virus (ZIKV) remains a significant global health threat due to its association with severe neurological disorders, yet no specific treatments are available. Ouabain (OUA) has demonstrated antiviral and immunomodulatory properties, but its mechanisms
José Marreiro de Sales-Neto, Daniel Wilson Arruda Magalhães, Deyse Cristina Madruga Carvalho, Poliana Gomes da Silva, Lindomar José Pena, Marcelo Tigre Moura, Sandra Rodrigues-Mascarenhas   +6 more
doaj   +2 more sources

Corrigendum: Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain [PDF]

Frontiers in Physiology, 2018
Luiz H. A. Cavalcante-Silva, Éssia de Almeida Lima, Deyse C. M. Carvalho, José M. de Sales-Neto, Anne K. de Abreu Alves, José G. F. M. Galvão, Juliane S. de França da Silva, Sandra Rodrigues-Mascarenhas, Sandra Rodrigues-Mascarenhas, Sandra Rodrigues-Mascarenhas   +9 more
doaj   +2 more sources

Beta-amyloid influences the content and trafficking of beta-amyloid precursor protein via Na,K-ATPase-Src kinase positive feedback loop [PDF]

Frontiers in Pharmacology
Beta-amyloid (Aβ) is an important factor in the development of pathology in Alzheimer’s disease. Level of beta-amyloid precursor protein (APP) is increased in neurites with age and in Alzheimer’s disease model mice.
Irina Y. Petrushanko, Denis R. Lisitskii, Filipp A. Filonov, Olga G. Leonova, Vladimir A. Mitkevich, Maria A. Strelkova, Alexander A. Makarov   +6 more
doaj   +2 more sources

Autonomic activity and its relationship with the endogenous cardiotonic steroid marinobufagenin: the African-PREDICT study [PDF]

Nutritional Neuroscience, 2020
Aletta E. Schutte, Olga Fedorova, Wayne Smith   +2 more
exaly   +2 more sources

Elevated Plasma Marinobufagenin, An Endogenous Cardiotonic Steroid, Is Associated With Right Ventricular Dysfunction and Nitrative Stress in Heart Failure [PDF]

Circulation: Heart Failure, 2015
David J Kennedy, Alexei Y Bagrov, Yuping Wu   +2 more
exaly   +2 more sources

Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na+/K+-ATPase Profibrotic Signaling Pathways [PDF]

International Journal of Molecular Sciences, 2018
David J Kennedy, Fatimah K Khalaf, Alexei Y Bagrov   +2 more
exaly   +2 more sources

Discovery of Ro 41-0960, a Non-Steroidal Inhibitor of the Na⁺/K⁺-ATPase. [PDF]

ChemMedChem
Ro 41‐0960 is a non‐steroidal Na+/K+‐ATPase inhibitor with low micromolar potency and a mixed inhibitory mechanism distinct from classical cardiotonic steroids, without acute pro‐arrhythmic effects in human cardiomyocytes. The Na+/K+‐ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure.
Cruz-Cortés C, Šeflová J, Guerrero-Serna G, Jimenez-Vazquez EN, Anumonwo J, Espinoza-Fonseca LM.   +5 more
europepmc   +2 more sources

A real-time PCR method to genotype mutant mouse models with altered affinity for cardiotonic steroids on the Na,K-ATPase

PLoS ONE, 2022
The highly conserved, cardiotonic steroid binding site (also termed ouabain binding site) on the primary α subunit of Na,K-ATPase plays a receptor signaling role in a range of vital cell processes and is a therapeutic target for human disease.
Peter W. Chomczynski, Kianna M. Vires, Michal Rymaszewski, Judith A. Heiny   +3 more
doaj   +2 more sources

The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B. [PDF]

RNA, 2012
Modulation of alternative pre-mRNA splicing is a potential approach to therapeutic targeting for a variety of human diseases. We investigated the mechanism by which digitoxin, a member of the cardiotonic steroid class of drugs, regulates alternative ...
Anderson ES, Lin CH, Xiao X, Stoilov P, Burge CB, Black DL.   +5 more
europepmc   +2 more sources