Results 31 to 40 of about 2,051 (160)

Bufalin inhibits the growth and epithelial to mesenchymal transition of human gastric cancer cells via modulation of MEK/ERK pathway

Bangladesh Journal of Pharmacology, 2021
This study was designed to evaluate the anti-cancer effects of bufalin against the human gastric cancer cells and unveil the underlying mechanism. The results showed that bufalin inhibited the proliferation and colony formation of the MGC-803 gastric ...
Yi Zhou, Liguo Wang, Hui Lin, Yunxia Wang, Kezhu Hou   +4 more
doaj   +1 more source

Bufalin induces mitochondrial dysfunction and promotes apoptosis of glioma cells by regulating Annexin A2 and DRP1 protein expression

Cancer Cell International, 2021
Background Glioma is a common primary central nervous system tumour, and therapeutic drugs that can effectively improve the survival rate of patients in the clinic are lacking.
Yao Li, Yan Zhang, Xufang Wang, Qian Yang, Xuanxuan Zhou, Junsheng Wu, Xu Yang, Yani Zhao, Rui Lin, Yanhua Xie, Jiani Yuan, Xiaohui Zheng, Siwang Wang   +12 more
doaj   +1 more source

Synthesis and Biological Evaluation of Novel Bufalin Derivatives

, 2022
Bufalin and other cardiac steroids (CS) have been used for centuries for the treatment of congestive heart failure, arrhythmias, and other maladies. However, toxicity and the small therapeutic window of this family of steroids limit their use. Therefore,
Shiv Vardan Singh, Hiba Zannadeh, Ilana Pogodin, Joseph Deutsch, VishnuPriya Sampath, Noa Horesh, Ben Sasi, David Lichtstein   +7 more
core   +1 more source

Bufalin targeting CAMKK2 inhibits the occurrence and development of intrahepatic cholangiocarcinoma through Wnt/β-catenin signal pathway

Journal of Translational Medicine, 2023
Background Intrahepatic cholangiocarcinoma (ICC) accounts for about 15% of primary liver cancer, and the incidence rate has been rising in recent years. Surgical resection is the best treatment for ICC, but the 5-year survival rate is less than 30%.
Huhu Zhang, Xiaolei Dong, Xiaoyan Ding, Guoxiang Liu, Fanghao Yang, Qinghang Song, Hongxiao Sun, Guang Chen, Shuang Li, Ya Li, Mengjun Wang, Tingting Guo, Zhe Zhang, Bing Li, Lina Yang   +14 more
doaj   +1 more source

Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC–MS/MS

Molecules, 2019
Characterization and determination of metabolites to monitor metabolic pathways play a paramount role in evaluating the efficacy and safety of medicines.
Wenlong Wei, Yang Yu, Xia Wang, Linhui Yang, Hang Zhang, Hongjian Ji, Zhenwei Li, Jinjun Hou, Wanying Wu, Dean Guo   +9 more
doaj   +1 more source

H-E staining of bufalin or 3-phospho-bufalin treated mouse heart.

, 2015
H&E staining of heart tissues 24 h after drug administration. Neither of bufalin or 3-phospho-bufalin caused severe damage to the heart muscle, indicating that the acute toxicity of bufalin is reversible.
Mingkun Zhao (803007), Xing Liu (221084), Feng Li (30515), Jianwei Chen (281404), Chengwei Zhang (573927), Jianming Xu (15308), Xiaosong Wang (14022), Hui Chen (28597), David M. Lonard (554019), Xianzhou Song (803006), Bert W. O’Malley (63322), Jin Wang (29560), Li Qin (205731)   +12 more
core   +1 more source

Electrocardiogram (EKG) measurements in mice treated with bufalin and 3-phospho-bufalin.

, 2015
Electrocardiogram (EKG) measurements in ICR mice treated with different doses of bufalin and 3-phospho-bufalin. EKG was measured 5 min before drug administration and 5, 10, 15 min and 24 h after drug administration. Significant changes in EKG output were
Mingkun Zhao (803007), Xing Liu (221084), Feng Li (30515), Jianwei Chen (281404), Chengwei Zhang (573927), Jianming Xu (15308), Xiaosong Wang (14022), Hui Chen (28597), David M. Lonard (554019), Xianzhou Song (803006), Bert W. O’Malley (63322), Jin Wang (29560), Li Qin (205731)   +12 more
core   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Pharmacokinetic (PK) parameters of 3-Phospho-bufalin.

, 2015
3-Phospho-bufalin (0.5 mg/kg by i.p.) were injected to female ICR mice (n = 3). Blood was collected at 5, 15, 30 min, and 1, 2, 4, 6, 12, and 24 h.
Mingkun Zhao (803007), Xing Liu (221084), Feng Li (30515), Jianwei Chen (281404), Chengwei Zhang (573927), Jianming Xu (15308), Xiaosong Wang (14022), Hui Chen (28597), David M. Lonard (554019), Xianzhou Song (803006), Bert W. O’Malley (63322), Jin Wang (29560), Li Qin (205731)   +12 more
core   +1 more source

Data_Sheet_1_Determination of Endogenous Bufalin in Serum of Patients With Hepatocellular Carcinoma Based on HPLC-MS/MS.pdf

, 2020
Bufalin is a cardiotonic steroid and a key active ingredient of the Chinese medicine ChanSu. It has significant anti-tumor activity against many malignancies, including hepatocellular carcinoma (HCC). Previous studies have shown that human bodies contain
Geliang Yang (8347641), Qing Lin (5273), Mengfei Han (8347638), Yanlong Yang (386386), Huiqing Zhang (727329), Yonghua Su (8347644)   +5 more
core   +1 more source