Results 11 to 20 of about 2,051 (160)

Improved Antitumor Efficacy and Pharmacokinetics of Bufalin via PEGylated Liposomes

Nanoscale Research Letters, 2017
Bufalin was reported to show strong pharmacological effects including cardiotonic, antiviral, immune-regulation, and especially antitumor effects. The objective of this study was to determine the characterization, antitumor efficacy, and pharmacokinetics
Jiani Yuan, Xuanxuan Zhou, Wei Cao, Linlin Bi, Yifang Zhang, Qian Yang, Siwang Wang   +6 more
doaj   +2 more sources

Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents [PDF]

Mediators of Inflammation, 2014
The aims of this study were to evaluate the anti-inflammatory and analgesic effects of bufalin, a major component of “Chan-su.” We used a carrageenan-induced paw edema model to assess the anti-inflammatory activity of this compound, and Western blot ...
Lili Wen, Yang Huang, Xianbiao Xie, Wan Huang, Junqiang Yin, Wenqian Lin, Qiang Jia, Weian Zeng   +7 more
doaj   +2 more sources

Targeting poly (ADP-ribose) polymerase partially contributes to bufalin-induced cell death in multiple myeloma cells. [PDF]

PLoS ONE, 2013
Despite recent pharmaceutical advancements in therapeutic drugs, multiple myeloma (MM) remains an incurable disease. Recently, ploy(ADP-ribose) polymerase 1 (PARP1) has been shown as a potentially promising target for MM therapy.
He Huang, Yang Cao, Wei Wei, Wei Liu, Shao-Yong Lu, Yu-Bao Chen, Yan Wang, Hua Yan, Ying-Li Wu   +8 more
doaj   +2 more sources

Bufalin Inhibits hTERT Expression and Colorectal Cancer Cell Growth by Targeting CPSF4

Cellular Physiology and Biochemistry, 2016
Background/Aims: Bufalin can induce apoptosis in certain human cancer cell lines, but bufalin has not yet been thoroughly evaluated in colorectal cancer cells.
Ningning Zhang, Yunpeng Xie, Yidi Tai, Yingying Gao, Wei Guo, Wendan Yu, Jia Li, Xu Feng, Jiaojiao Hao, Yue Gao, Xinrui Zhao, Yina Liao, Wei Jiang, Ge Liu, Wuguo Deng, Xiaonan Cui   +15 more
doaj   +2 more sources

Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. [PDF]

PLoS ONE, 2012
Bufalin is the primary component of the traditional Chinese herb "Chan Su". Evidence suggests that this compound possesses potent anti-tumor activities, although the exact molecular mechanism(s) is unknown.
Xian-biao Xie, Jun-qiang Yin, Li-li Wen, Zhen-hua Gao, Chang-ye Zou, Jin Wang, Gang Huang, Qing-lian Tang, Chiara Colombo, Wei-ling He, Qiang Jia, Jing-nan Shen   +11 more
doaj   +2 more sources

Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress

Biology Open, 2017
Bufalin has been used to treat cancer for several years. However, the molecular mechanisms for its anti-tumor function are not fully understood. This work aimed to investigate the effect of bufalin on the proliferation and apoptosis of human gastric ...
Hongyan Zhao, Qinghua Li, Jie Pang, Huilin Jin, Hongwei Li, Xiaoying Yang   +5 more
doaj   +2 more sources

Bufalin Suppresses Esophageal Squamous Cell Carcinoma Progression through Protein Arginine Methyltransferase-6/AKT/Mammalian Target of Rapamycin Pathway Inhibition

World Journal of Traditional Chinese Medicine
Objective: Esophageal squamous cell carcinoma (ESCC), a commonly encountered malignant tumor in the gastrointestinal tract, poses a significant health burden.
Yao-Ke Jia, Qian-Qian Ju, Hui Shi, Xin-Xin Si   +3 more
doaj   +2 more sources

Inhibition of Jak-STAT3 pathway enhances bufalin-induced apoptosis in colon cancer SW620 cells

World Journal of Surgical Oncology, 2012
Background The purpose of the research is to investigate the roles of Jak-STAT3 signaling pathway in bufalin-induced apoptosis in colon cancer SW620 cells.
Zhu Zhitu, Li Enze, Liu Yangyang, Gao Yu, Sun Hongzhi, Ma Guangyou, Wang Zhenghua, Liu Xiaomei, Wang Qingjun, Qu Xiujuan, Liu Yunpeng, Yu Yunlong   +11 more
doaj   +2 more sources

Preparation of bufalin-loaded pluronic polyetherimide nanoparticles, cellular uptake, distribution, and effect on colorectal cancer

International Journal of Nanomedicine, 2014
Qiang Hu,1,3,* Bo Liang,2,* Ying Sun,4 Xiao-Ling Guo,2,* Yi-Jie Bao,2 Dong-Hao Xie,3 Ming Zhou,3 You-Rong Duan,4 Pei-Hao Yin,2 Zhi-Hai Peng11Department of Hepatobiliary Surgery, Qianfoshan Hospital, Shandong University, Jinan, 2Department of General ...
Hu Q, Liang B, Sun Y, Guo XL, Bao YJ, Xie DH, Zhou M, Duan YR, Yin PH, Peng ZH   +9 more
doaj   +1 more source

Bufalin Inhibits Melanoma Progression and Endothelial Angiogenic Phenotypes via AKT Signaling. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Introduction Bufalin (BF) exhibits anti‐tumor activity in many tumor types. However, there are few reports on BF in melanoma, and its pharmacological effects have not yet been elucidated. The present study aimed to investigate the effects of BF on melanoma and angiogenesis and to explore its possible mechanism.
Zhao XX, Li MX, Qu JX.
europepmc   +2 more sources