Results 91 to 100 of about 2,051 (160)

Additional file 1: of Bufalin-Loaded PEGylated Liposomes: Antitumor Efficacy, Acute Toxicity, and Tissue Distribution

, 2019
Figure S1. Characterization of PEGylated liposomes containing bufalin. Figure S2. Representative chromatograms of BF and CBG (IS) in rat tissue homogenate samples. Table S1.
Jiani Yuan (1563913), Qian Yang (300330), Yang Pan (337821), Yanhua Xie (1563916), Xuanxuan Zhou (4583728), Wei Cao (50866), Yifang Zhang (625731), Cheng Zeng (621718), Siwang Wang (431208)   +8 more
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Bufalin functions as an inhibitor of PARP1 in cells.

, 2013
(A) H929 cells were pretreated with indicated concentrations of bufalin or olaparib for 1 h, and then exposed to 100 nM topotecan for another 1 h. Poly (ADP-ribosyl)ation was measured by western blot. (B) H929 cells were cultured with DMSO, 20 nM bufalin,
He Huang (50693), Shao-Yong Lu (419614), Yan Wang (15435), Yu-Bao Chen (419615), Hua Yan (211621), Ying-Li Wu (419616), Wei Wei (21173), Wei Liu (20030), Yang Cao (53545)   +8 more
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Bufalin interacts with PARP1 and inhibits PARP1 activity in vitro.

, 2013
(A–B) Whole cell lysates of U266 cells were incubated with bufalin followed by digestion with pronase according to “Materials and Methods”. Then, the degree of Na+-K+-ATPase (A) or PARP1 (B) degradation was determined by western blot.
He Huang (50693), Shao-Yong Lu (419614), Yan Wang (15435), Yu-Bao Chen (419615), Hua Yan (211621), Ying-Li Wu (419616), Wei Wei (21173), Wei Liu (20030), Yang Cao (53545)   +8 more
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Bufalin suppresses hepatocarcinogenesis by targeting β-catenin/TCF signaling via cell cycle-related kinase

, 2018
Hepatocellular carcinoma (HCC) is one of the most aggressive malignant tumors, of which treatment options are limited especially in advanced stage. Bufalin, the major digoxin-like component of the traditional Chinese medicine Chansu, exhibits significant
Alfred Szelok Cheng, Xin Zhang, Chao Zheng, Hai Feng, Xuehua Sun, Man Li, Lingying Huang, Yun Jiang, Xiaojun Zhu, Zhenhua Zhou, Yunhui Zhuo, Zhuo Yu, Fan Le, Yueqiu Gao   +13 more
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ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy

Cancer Cell International
Despite advancements in treating metastatic melanoma, many patients exhibit resistance to targeted therapies. Our study focuses on ATP1A1, a sodium pump subunit associated with cancer development.
Laura Soumoy, Aline Genbauffe, Lena Mouchart, Alexandra Sperone, Anne Trelcat, Léa Mukeba-Harchies, Mathilde Wells, Bertrand Blankert, Ahmad Najem, Ghanem Ghanem, Sven Saussez, Fabrice Journe   +11 more
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Bufalin synergizes with sorafenib to induce apoptosis in HCC cells.

, 2015
HepG2 and Huh7 cells were incubated with 100 nM bufalin and/or 5 μM sorafenib for 48 h. (A) The cells were stained with Annexin V/PI and subjected to flow cytometry to measure the apoptosis rate (%).
Xueying Sun (201047), Shangha Pan (201039), Fengli Hu (113458), Haijiang Yan (797379), Dali Zhao (797380), Xin Jin (108988), Bo Zhai (113456), Taishi Fang (797381), Lishan Xu (797382)   +8 more
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Figures S1-S5 from Role of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin

, 2018
Figure S1 shows A. Concentration-dependent reduction of number of adherent LNCaP cells exposed to increasing concentrations of bufalin for 96 h; B. Representative photomicrograph of LNCaP cells exposed to bufalin at 2 concentrations for 48 h.
Hongbo Hu (574041), Kartick Pramanik (15070962), Yinhui Dong (1874257), Junxuan Lu (41183), Wei Wu (27708), Sangyub Kim (15070965), Michael W. Melkus (8485434), Su-Ni Tang (333213), Yong Zhang (5893), Shutao Yin (15070959), Peixin Jiang (12534507), Cheng Jiang (41176), Min Ye (171404)   +12 more
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Multi-b-value DWI to evaluate the synergistic antiproliferation and anti-heterogeneity effects of bufalin plus sorafenib in an orthotopic HCC model

European Radiology Experimental
Background Multi-b-value diffusion-weighted imaging (DWI) with different postprocessing models allows for evaluating hepatocellular carcinoma (HCC) proliferation, spatial heterogeneity, and feasibility of treatment strategies.
Ran Guo, Fang Lu, Jiang Lin, Caixia Fu, Mengxiao Liu, Shuohui Yang   +5 more
doaj   +1 more source

Bufalin induces G(0)/G(1) phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells.

, 2012
[[abstract]]Most of the chemotherapy treatments for bladder cancer aim to kill the cancer cells, but a high recurrence rate after medical treatments is still occurred.
闕甫伈;Chueh, Fu-Shin;范宗宸;Fan, Ming-Jen;Chen, Po-Yuan;Tsuzuki, Minoru;鍾景光;Chung, Jing-Gung
core  

Bufalin Induces Ferroptosis in Triple-Negative Breast Cancer via Inhibition of the NRF2/HO-1/GPX4 Pathway

Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer characterized by poor prognosis and limited therapeutic options, remains a major clinical challenge.
Ke-Yan Chai, Mei-Ling Guo, Hua Luo, Jia-Rui Wu, Si-Yu Guo, An-Xin Wang, Ji-Ying Zhou, Fan-Qin Zhang, Min Jin, Muyassar Mamattohti, Pei-Ying Lu   +10 more
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