Results 81 to 90 of about 2,051 (160)

Pharmacokinetics (PK) of 3-Phospho-bufalin (p-Buf).

, 2015
PK trace of p-buf (orange) and free bufalin generated from p-buf (blue) in mice treated with p-buf (0.5 mg/kg). The blue and orange dotted lines represent the lower limit of quantification (LLOQ) for bufalin and p-buf in this assay, respectively.
Mingkun Zhao (803007), Xing Liu (221084), Feng Li (30515), Jianwei Chen (281404), Chengwei Zhang (573927), Jianming Xu (15308), Xiaosong Wang (14022), Hui Chen (28597), David M. Lonard (554019), Xianzhou Song (803006), Bert W. O’Malley (63322), Jin Wang (29560), Li Qin (205731)   +12 more
core   +1 more source

Effect of Bufalin on Proliferation and Apoptosis of Human Non-small Cell Lung Cancer A549 Cell

Chinese Journal of Lung Cancer, 2010
Background and objective Bufalin, a component of the Chinese medicine chan'su, induces apoptosis in various human tumor cell lines. The aim of this study is to investigate the mechanism of anti-proliferation and the induction of apoptosis of Bufalin on ...
Zhitu ZHU, Yunlong YU, Kai WANG, Enze LI, Yangyang LIU, Yunpeng LIU   +5 more
doaj  

Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives

World Journal of Traditional Chinese Medicine, 2015
Toad venom, called as ChanSu in China, is a widely used traditional Chinese medicine (TCM) whose active components are mainly bufadienolides. ChanSu could exhibit cardiotonic, anti-microbial, anti-inflammatory and, most importantly, anti-cancer effects ...
Miao Liu, Li-Xing Feng, Li-Hong Hu, Xuan Liu, De-An Guo   +4 more
doaj   +1 more source

ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells

, 2000
Treatment of human leukemia THP-1 cells with bufalin, a specific inhibitor of Na+-K+-ATPase, sequentially induces c- fos and inflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) gene expressions before the appearance of ...
Takemi Yoshida, Satoshi Numazawa, Masahiro Kurosawa, Yoshihiro Tani   +3 more
core   +1 more source

Research on the cytostatic effect of bufalin on cervical carcinoma cells and the related mechanism

Zhongguo aizheng zazhi, 2015
Background and purpose: Cervical cancer remains the second leading cause of death in gynecologic malignancies partially because of resistance to chemotherapy. Bufalin, a component of the traditional Chinese medicine Chansu, has been widely used in cancer
刘　霏, 李浩然, 程　玺
doaj  

Bufalin Alters Gene Expressions Associated DNA Damage, Cell Cycle, and Apoptosis in Human Lung Cancer NCI-H460 Cells in Vitro

Molecules, 2014
Lung cancer is the leading cause of cancer related death and there is no effective treatment to date. Bufalin has been shown effective in inducing apoptosis and DNA damage in lung cancer cells.
Shin-Hwar Wu, Yung-Ting Hsiao, Jaw-Chyum Chen, Ju-Hwa Lin, Shu-Chun Hsu, Te-Chun Hsia, Su-Tso Yang, Wu-Huei Hsu, Jing-Gung Chung   +8 more
doaj   +1 more source

Transferrin and folic acid co-modified bufalin-loaded nanoliposomes: preparation, characterization, and application in anti-cancer activity

, 2018
Qiankun Chen,1 Ji Liu2 1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China; 2Department of Anesthesia, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Aim:
Chen Q, Liu J
core  

Bufalin downregulates SRC–3 and decreases cell viability in TNBC cells.

, 2015
(A) Western blot shows that bufalin (100 nM) downregulates SRC–3 protein levels in TNBC cells. IC50 values, TNBC subtypes and gene ontologies are also listed.
Mingkun Zhao (803007), Xing Liu (221084), Feng Li (30515), Jianwei Chen (281404), Chengwei Zhang (573927), Jianming Xu (15308), Xiaosong Wang (14022), Hui Chen (28597), David M. Lonard (554019), Xianzhou Song (803006), Bert W. O’Malley (63322), Jin Wang (29560), Li Qin (205731)   +12 more
core   +1 more source

Bufalin-Inhibited Migration and Invasion in Human Osteosarcoma U-2 OS Cells Is Carried Out by Suppression of the Matrix Metalloproteinase-2, ERK, and JNK Signaling Pathways

, 2014
[[abstract]]Bufalin has been shown to exhibit multiple pharmacological activities, including induction of apoptosis in many types of cancer cell lines.
Fu-Shin Chueh;Ya-Yin Chen;An-Cheng Huang;Heng-Chien Ho;Ching-Lung Liao;Jai-Sing Yang;Chao-Lin Kuo;Jing-Gung Chung
core   +1 more source

Global trends in bufalin application research for cancer from 2003 to 2022: A bibliometric and visualised analysis

Heliyon
Background: Bufalin, the main active ingredient of the traditional Chinese medicine huachansu, is used in the clinical treatment of colorectal cancer and has multiple effects, including the inhibition of migratory invasion, reversal of multi-drug ...
Donghao Tang, Yuejiao Feng, Jiahao Lu, Linlin Jia, Dongxiao Shen, Jing Shang, Teng Chen, Peihao Yin, Jinbao Chen, Jie Wang   +9 more
doaj   +1 more source