Results 11 to 20 of about 102,685 (330)

Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro [PDF]

Scientific Reports, 2016
Retrospective studies indicate that the use of regional anesthesia can reduce cancer recurrence after surgery which could be due to ranging from immune function preservation to direct molecular mechanisms.
W. Xuan, Hailin Zhao, J. Hankin, Lin Chen, S. Yao, D. Ma   +5 more
semanticscholar   +10 more sources

iTRAQ proteomics analysis reveals that PI3K is highly associated with bupivacaine‐induced neurotoxicity pathways [PDF]

Proteomics, 2016
Bupivacaine, a commonly used local anesthetic, has potential neurotoxicity through diverse signaling pathways. However, the key mechanism of bupivacaine-induced neurotoxicity remains unclear.
Wei Zhao, Zhongjie Liu, Xu-jiao Yu, Luying Lai, Haobo Li, Zipeng Liu, Le Li, Shan Jiang, Z. Xia, Shi-Yuan Xu   +9 more
semanticscholar   +2 more sources

Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model. [PDF]

PLoS ONE, 2015
BACKGROUND:Dexamethasone has been studied as an effective adjuvant to prolong the analgesia duration of local anesthetics in peripheral nerve block. However, the route of action for dexamethasone and its potential neurotoxicity are still unclear. METHODS:
Ke An, Nabil M Elkassabany, Jiabin Liu
doaj   +2 more sources

Bupivacaine modulates the apoptosis and ferroptosis in bladder cancer via phosphatidylinositol 3-kinase (PI3K)/AKT pathway

Bioengineered, 2022
The study aimed to explore the effects of local anesthetic bupivacaine on bladder cancer cells in vivo and in vitro. The cytotoxicity was detected by MTT assay. Apoptosis was measured by Hoechst 33342 staining and TUNEL.
Jianli Hao, Weiqing Zhang, Zeqing Huang
semanticscholar   +1 more source

Efficacy of Liposomal Bupivacaine and Bupivacaine Hydrochloride vs Bupivacaine Hydrochloride Alone as a Periarticular Anesthetic for Patients Undergoing Knee Replacement

JAMA Surgery, 2022
This randomized clinical trial assesses the efficacy and cost-effectiveness of liposomal bupivacaine plus bupivacaine hydrochloride compared with bupivacaine hydrochloride alone for postoperative recovery and pain management among patients undergoing ...
T. Hamilton, R. Knight, Jamie R. Stokes, I. Rombach, C. Cooper, L. Davies, S. Dutton, K. Barker, J. Cook, S. Lamb, D. Murray, Lisa Poulton, Ariel Wang, L. Strickland, B. V. van Duren, J. Leal, D. Beard, H. Pandit   +17 more
semanticscholar   +1 more source

Analgesia Quality and Duration of Fentanyl and Sufentanil Added to Bupivacaine in Spinal Anesthesia in Inguinal Hernia Surgery: A Double-Blind Parallel Randomized Controlled Trial. [PDF]

Health Sci Rep
ABSTRACT Background and Aims To compare the quality and duration of analgesia provided by Fentanyl and Sufentanil when added to 12–15 mg Bupivacaine 0.5% in spinal anesthesia for inguinal hernia surgery. Methods In the present double‐blind parallel Randomized Controlled Trial (RCT), 180 patients who were candidates for elective inguinal hernia surgery ...
Soleimany H, Tavan H, Khalighi E, Pakzad R.   +3 more
europepmc   +2 more sources

Perineural Liposomal Bupivacaine Is Not Superior to Nonliposomal Bupivacaine for Peripheral Nerve Block Analgesia.

Anesthesiology, 2020
BACKGROUND Liposomal bupivacaine is purported to extend analgesia of peripheral nerve blocks when administered perineurally. However, evidence of the clinical effectiveness of perineural liposomal bupivacaine is mixed.
N. Hussain, R. Brull, Brendan Sheehy, M. Essandoh, D. Stahl, T. Weaver, F. Abdallah   +6 more
semanticscholar   +1 more source

Clinical Effectiveness of Liposomal Bupivacaine Administered by Infiltration or Peripheral Nerve Block to Treat Postoperative Pain.

Anesthesiology, 2020
The authors provide a comprehensive summary of all randomized, controlled trials (n = 76) involving the clinical administration of liposomal bupivacaine (Exparel; Pacira Pharmaceuticals, USA) to control postoperative pain that are currently published ...
B. Ilfeld, J. Eisenach, R. Gabriel
semanticscholar   +1 more source

Transversus Abdominis Plane Block With Liposomal Bupivacaine for Pain After Cesarean Delivery in a Multicenter, Randomized, Double-Blind, Controlled Trial

Anesthesia and Analgesia, 2020
BACKGROUND: In women undergoing cesarean delivery under spinal anesthesia with intrathecal morphine, transversus abdominis plane (TAP) block with bupivacaine hydrochloride (HCl) may not improve postsurgical analgesia.
S. Nedeljkovic, A. Kett, M. Vallejo, J. Horn, B. Carvalho, X. Bao, Naida M. Cole, Leslie A. Renfro, J. Gadsden, Jia Song, Julia Yang, A. Habib   +11 more
semanticscholar   +1 more source

Mepivacaine versus Bupivacaine Spinal Anesthesia for Early Postoperative Ambulation

Anesthesiology, 2020
Background: Early ambulation after total hip arthroplasty predicts early discharge. Spinal anesthesia is preferred by many practices but can delay ambulation, especially with bupivacaine. Mepivacaine, an intermediate-acting local anesthetic, could enable
E. Schwenk, V. Kasper, J. Smoker, Andrew M. Mendelson, M. Austin, Scot Brown, W. Hozack, Alexa J. Cohen, Jonathan J Li, Christopher Wahal, Jaime L. Baratta, M. Torjman, Alyson C Nemeth, Eric E Czerwinski   +13 more
semanticscholar   +1 more source