Results 1 to 10 of about 10,504 (228)

Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering

Advanced Science, 2020
Organophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic reactivators of cholinesterase‐organophosphate complexes, but suffer from ...
Krzysztof Matyjaszewski, Alan J Russell, Lin Cheng   +2 more
exaly   +2 more sources

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study

Pharmaceuticals, 2023
Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles.
Bushra Adalat, Fazal Rahim, Wajid Rehman, Zarshad Ali, Liaqat Rasheed, Yousaf Khan, Thoraya A. Farghaly, Sulaiman Shams, Muhammad Taha, Abdul Wadood, Syed A. A. Shah, Magda H. Abdellatif   +11 more
doaj   +1 more source

Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase. [PDF]

PLoS ONE, 2013
Concerns about the safety of paralytics such as succinylcholine to facilitate endotracheal intubation limit their use in prehospital and emergency department settings.
Brian C Geyer, Katherine E Larrimore, Jacquelyn Kilbourne, Latha Kannan, Tsafrir S Mor   +4 more
doaj   +1 more source

Wide awake under anesthesia: Scoline apnoea update [PDF]

Serbian Journal of Anesthesia and Intensive Therapy, 2016
Butyrylcholinesterase (BChE) catalyses the hydrolysis of choline esters and thus deactivates muscle relaxants such as succinylcholine and mivacurium. The prolonged neuromuscular blockade following the use of succinylcholine, called scoline apnea, occurs ...
Marković Danica, Janković Radmilo J.
doaj   +1 more source

Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold. [PDF]

PLoS ONE, 2018
This paper describes the synthesis and anticholinesterase potency of Cinchona-based alkaloids; ten quaternary derivatives of cinchonines and their corresponding pseudo-enantiomeric cinchonidines. The quaternization of quinuclidine moiety of each compound
Anita Bosak, Alma Ramić, Tamara Šmidlehner, Tomica Hrenar, Ines Primožič, Zrinka Kovarik   +5 more
doaj   +1 more source

Surrogate Markers of the Kidney and Liver in the Assessment of Gestational Diabetes Mellitus and Fetal Outcome [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: To investigate whether serum levels of butyrylcholinesterase activity, cystatin C, and pre-albumin has the potential value as γ-glutamyl transferase in reflecting gestational diabetes mellitus and its fetal outcome. Materials and Methods:
Hong Liu, Shao-Gang Ma, Liang Cheng, Feng Bai, Wei Xu   +4 more
doaj   +1 more source

The role of butyrylcholinesterase in the regulation of cognitive dysfunction in minimal hepatic encephalopathy: A potential blood marker of disease evolution

Frontiers in Neurology, 2022
Background and aimsPatients with cirrhosis commonly experience minimal hepatic encephalopathy (MHE), and alterations in neurotransmitters have been thought to be related to cognitive function.
Xuhong Yang, Pei Dang, Wenxiao Liu, Wanlong Ma, Xin Ge, Kai Zhu, Minglei Wang, Xueying Huang, Xiangchun Ding, Xiaodong Wang   +9 more
doaj   +1 more source

Discovery of pyrrole derivatives as acetylcholinesterase-sparing butyrylcholinesterase inhibitor

Frontiers in Pharmacology, 2022
Inspired by the crucial roles of (hetero)aryl rings in cholinesterase inhibitors and the pyrrole ring in new drug discovery, we synthesized 19 pyrrole derivatives and investigated their cholinesterase inhibitory activity.
Shouyuan Sun, Tao Shi, Yan Peng, Honghua Zhang, Linsheng Zhuo, Xue Peng, Qien Li, Manxia Wang, Shuzhi Wang, Zhen Wang, Zhen Wang   +10 more
doaj   +1 more source

Serum cholinesterases are differentially regulated in normal and dystrophin-deficient mutant mice

Frontiers in Molecular Neuroscience, 2012
The cholinesterases, acetylcholinesterase and butyrylcholinesterase (pseudocholinesterase), are abundant in the nervous system and in other tissues. The role of acetylcholinesterase in terminating transmitter action in the peripheral and central nervous ...
Andrea R. Durrant, Liliya eTamayev, Lili eAnglister   +2 more
doaj   +1 more source

Influence of obstructive sleep apnea on serum butyrylcholinesterase activity and ischemia-modified albumin levels

Clinics, 2013
OBJECTIVE: To investigate the effect of obstructive sleep apnea and continuous positive airway pressure treatment on serum butyrylcholinesterase activity and ischemia-modified albumin levels.
Liu-Xue Yang, Shao-Gang Ma, Hong Liu, Wei Xu   +3 more
doaj   +1 more source