Results 1 to 10 of about 11,286 (211)

Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase [PDF]

Frontiers in Pharmacology, 2018
Butyrylcholinesterase (BChE), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (AChE) but with the capability to degrade a broad range of bioactive esters.
Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P. Chen   +3 more
doaj   +2 more sources

2,5‐Bis(4‐phenethylpiperazin‐1‐yl)‐1,4‐benzoquinone: Harnessing AChE Selectivity for Alzheimer's Disease Therapy. [PDF]

Alzheimers Dement
Abstract Background The present study recounts the potency of the novel synthesized 2,5‐Bis(4‐phenethylpiperazin‐1‐yl)‐1,4‐benzoquinone (P‐1) as a potent molecule selectively targeting AChE along with the antioxidant action that helps to manage cognitive decline in Alzheimer’s disease.
Silakari P, Yadav A, Piplani P.
europepmc   +2 more sources

Alzheimer's mice model APP‐knock‐in displays altered hippocampal cholinergic function [PDF]

Alzheimers Dement
Abstract Background The hippocampal region of the brain is a crucial site of neurotrophic factor production like nerve growth factor (NGF) – the master regulator of cholinergic pathways and brain derived neurotrophic factor (BDNF). Hippocampus coordinates memory and cognition and is found affected with amyloid‐beta (Aβ) pathology in AD.
Mitra S, Gera R, Tambaro S, Nilsson P, Linderoth B, Behbahani H, Darreh‐Shori T, Eriksdotter M.   +7 more
europepmc   +2 more sources

Butyrylcholinesterase-Loaded Liposomes and Polymersomes: Catalytic Parameters for Three Types of Substrates. [PDF]

Int J Mol Sci
Shaihutdinova Z, Batasheva S, Masson P, Pashirova T.   +3 more
europepmc   +3 more sources

The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke

Cerebral Circulation - Cognition and Behavior, 2021
Aim: Our study aimed to test whether plasma acetylcholinesterase and butyrylcholinesterase enzyme activity were related to the presence and intensity of delirium in acute stroke patients.
Lara Caeiro, Filipa Novais, Carlota Saldanha, Teresa Pinho e Melo, Patrícia Canhão, José M. Ferro   +5 more
doaj   +1 more source

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study

Pharmaceuticals, 2023
Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles.
Bushra Adalat, Fazal Rahim, Wajid Rehman, Zarshad Ali, Liaqat Rasheed, Yousaf Khan, Thoraya A. Farghaly, Sulaiman Shams, Muhammad Taha, Abdul Wadood, Syed A. A. Shah, Magda H. Abdellatif   +11 more
doaj   +1 more source

Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase. [PDF]

PLoS ONE, 2013
Concerns about the safety of paralytics such as succinylcholine to facilitate endotracheal intubation limit their use in prehospital and emergency department settings.
Brian C Geyer, Katherine E Larrimore, Jacquelyn Kilbourne, Latha Kannan, Tsafrir S Mor   +4 more
doaj   +1 more source

5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study

Pharmaceuticals, 2022
2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia ...
Václav Pflégr, Šárka Štěpánková, Katarína Svrčková, Markéta Švarcová, Jarmila Vinšová, Martin Krátký   +5 more
doaj   +1 more source

Surrogate Markers of the Kidney and Liver in the Assessment of Gestational Diabetes Mellitus and Fetal Outcome [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: To investigate whether serum levels of butyrylcholinesterase activity, cystatin C, and pre-albumin has the potential value as γ-glutamyl transferase in reflecting gestational diabetes mellitus and its fetal outcome. Materials and Methods:
Hong Liu, Shao-Gang Ma, Liang Cheng, Feng Bai, Wei Xu   +4 more
doaj   +1 more source

Software for Matching Standard Activity Enzyme Biosensors for Soil Pollution Analysis

Sensors, 2021
This work is dedicated to developing enzyme biosensor software to solve problems regarding soil pollution analysis. An algorithm and specialised software have been developed which stores, analyses and visualises data using JavaScript programming language.
Valentina A. Kratasyuk, Elizaveta M. Kolosova, Oleg S. Sutormin, Viktoriya I. Lonshakova-Mukina, Matvey M. Baygin, Nadezhda V. Rimatskaya, Irina E. Sukovataya, Alexander A. Shpedt   +7 more
doaj   +1 more source