Results 21 to 30 of about 11,286 (211)
Molecules, 2017 Human butyrylcholinesterase is a performant stoichiometric bioscavenger of organophosphorous nerve agents. It is either isolated from outdated plasma or functionally expressed in eukaryotic systems.
Xavier Brazzolotto +4 more
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Cord Blood Butyrylcholinesterase Activities in Normal Pregnant and Preeclamptic Women
Avicenna Journal of Medical Biochemistry, 2016 Background Human placenta, a non-neural tissue, contains cholinergic system and high-affinity muscarinic receptors. The role of cholinesterases (CE) in trophoblast function and pregnancy is not clear. Objectives
Kharb +5 more
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Diagnostics, 2022 A biomarker for risk stratification and disease severity assessment in SARS-CoV-2 infections has not yet been established. Point of care testing (POCT) of butyrylcholinesterase (BChE) enables early detection of systemic inflammatory responses and ...
Florian Espeter +7 more
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Serum butyrylcholinesterase in type 2 diabetes mellitus: a biochemical and bioinformatics approach
Lipids in Health and Disease, 2005 Background Butyrylcholinesterase is an enzyme that may serve as a marker of metabolic syndrome. We (a) measured its level in persons with diabetes mellitus, (b) constructed a family tree of the enzyme using nucleotide sequences downloaded from NCBI ...
Sreelatha S +6 more
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Biology, 2021 Butyrylcholinesterase (BChE) is detected in plaques preferentially in Alzheimer’s disease (AD) and may be associated with stress disorders. However, the physiological function of BChE in the central nervous system remains to be further investigated. BChE
Weiwei Liu +6 more
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Butyrylcholinesterase deficiency identified after succinylcholine administration. Case report
Iatreia, 2018 The main function of the enzyme butyrylcholinesterase is to hydrolyze exogenous esters such as those present in the neuromuscular blocking agent succinylcholine, which is frequently used in short surgical procedures.
Manzano Rincón, Yolima +3 more
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Molecules, 2021 The multi-target-directed ligands (MTDLs) strategy is encouraged for the development of novel modulators targeting multiple pathways in the neurodegenerative cascade typical for Alzheimer’s disease (AD). Based on the structure of an in-house irreversible
Tjaša Mazej +4 more
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Comparison of butyrylcholinesterase and acetylcholinesterase [PDF]
Biochemical Journal, 1989 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are compared, the first focus being on the high homologies of the molecular forms, and the homologies in protein sequences. Cholinesterases are the prototype of a new family of related serine hydrolases. Secondly, the distribution and regulation of AChE and BChE is reviewed.
Chatonnet, Arnaud, Lockridge, O.
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Butyrylcholinesterase and Cognitive Function
International Psychogeriatrics, 2001 Butyrylcholinesterase (BuChE) is expressed in brain structures involved in cognition, but the effect of selective BuChE inhibitors on human cognitive function is unknown. We report a patient whose cognitive function deteriorated following a reduction and improved following reinstitution of ethopropazine, a selective BuChE inhibitor.
S, Darvesh, C, MacKnight, K, Rockwood
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Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering
Advanced Science, 2020 Organophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic reactivators of cholinesterase‐organophosphate complexes, but suffer from ...
Libin Zhang +7 more
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