Results 41 to 50 of about 10,504 (228)

Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity

Molecules, 2022
Transformations of 1-methoxymethylethynyl substituted isoquinolines triggered by terminal alkynes in alcohols were studied and new 3-benzazecine-containing compounds synthesized, such as 6-methoxymethyl-3-benzazecines incorporating an endocyclic C6–C8 ...
Alexander A. Titov, Rosa Purgatorio, Arina Y. Obydennik, Anna V. Listratova, Tatiana N. Borisova, Modesto de Candia, Marco Catto, Cosimo D. Altomare, Alexey V. Varlamov, Leonid G. Voskressensky   +9 more
doaj   +1 more source

Chemical Composition, Antioxidant, Antimicrobial, Antidiabetic, and Butyrylcholinesterase Inhibitory Activities in Vitro of the Essential Oil and Crude Extracts of the Aerial Parts of Thymus ciliatus

Chemistry &Biodiversity, EarlyView.
ABSTRACT This study explores the potential of Thymus ciliatus as a natural source of bioactive compounds by investigating its chemical composition and in vitro biological activities, including antioxidant, antimicrobial, antidiabetic, and anti‐Alzheimer properties.
Nadia Djermane, Mostapha Brahmi, Djallal Eddine Adli, Micaela Gliozzi, Vincenzo Musolino, Rebbas Khellaf, Ramazan Erenler, Rabah Arhab, Stefania Garzoli   +8 more
wiley   +1 more source

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

Molecules, 2017
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission.
Terrone L. Rosenberry, Xavier Brazzolotto, Ian R. Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nachon   +6 more
doaj   +1 more source

Critically Ill COVID-19 Patients Show Reduced Point of Care-Measured Butyrylcholinesterase Activity—A Prospective, Monocentric Observational Study

Diagnostics, 2022
A biomarker for risk stratification and disease severity assessment in SARS-CoV-2 infections has not yet been established. Point of care testing (POCT) of butyrylcholinesterase (BChE) enables early detection of systemic inflammatory responses and ...
Florian Espeter, David Künne, Lena Garczarek, Henning Kuhlmann, Annabell Skarabis, Aleksandar R. Zivkovic, Thorsten Brenner, Karsten Schmidt   +7 more
doaj   +1 more source

The Phenolic Content and Bioactivity Assessment of Rubus sanctus Schreber Species with Potential for Food and Ethnopharmacological Uses

Chemistry &Biodiversity, EarlyView.
ABSTRACT In this study, the phytochemical content and various biological activities of Rubus sanctus Schreber species, widely distributed in Turkiye and used in folk medicine, were determined. The ethanol extracts of the root and aerial parts of the species were prepared and their bioactive phytochemical composition was identified by liquid ...
Ismail Yener
wiley   +1 more source

Evaluation of cholinergic enzymes and selected biochemical parameters in the serum of patients with a diagnosis of acute subarachnoid hemorrhage

Translational Neuroscience, 2023
Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5–7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH ...
Aycan Abdurrahman, Tas Abdurrahim, Yeltekin Asli Cilingir, El-Tekreti Sama Amer Abbas, Arslan Ayse, Arslan Mustafa, Aycan Nur   +6 more
doaj   +1 more source

Software for Matching Standard Activity Enzyme Biosensors for Soil Pollution Analysis

Sensors, 2021
This work is dedicated to developing enzyme biosensor software to solve problems regarding soil pollution analysis. An algorithm and specialised software have been developed which stores, analyses and visualises data using JavaScript programming language.
Valentina A. Kratasyuk, Elizaveta M. Kolosova, Oleg S. Sutormin, Viktoriya I. Lonshakova-Mukina, Matvey M. Baygin, Nadezhda V. Rimatskaya, Irina E. Sukovataya, Alexander A. Shpedt   +7 more
doaj   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Targeting acetylcholinesterase and butyrylcholinesterase in dementia [PDF]

The International Journal of Neuropsychopharmacology, 2005
The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain acetylcholinesterase (AChE) has been the major therapeutic target of ChE-I treatment strategies for Alzheimer's disease (AD).
Steven G. Potkin, Roger Lane, Albert Enz
openaire   +2 more sources

The biological activities of butyrylcholinesterase inhibitors

Biomedicine & Pharmacotherapy, 2022
Acetylcholinesterase (AChE) inhibitor is the first choice for the treatment of Alzheimer's disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term treatment effect. Recent studies have shown that butyrylcholinesterase (BuChE) inhibitors or double acetyl and butyryl cholinesterase inhibitors have better curative ...
Shiyang, Zhou, Gangliang, Huang
openaire   +2 more sources