Results 41 to 50 of about 11,286 (211)

Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase [PDF]

International Journal of Molecular Sciences, 2013
Caffeine is an alkaloid with a stimulant effect in the body. It can interfere in transmissions based on acetylcholine, epinephrine, norepinephrine, serotonin, dopamine and glutamate. Clinical studies indicate that it can be involved in the slowing of Alzheimer disease pathology and some other effects. The effects are not well understood. In the present
Miroslav Pohanka, Petr Dobes
openaire   +2 more sources

Evaluation of cholinergic enzymes and selected biochemical parameters in the serum of patients with a diagnosis of acute subarachnoid hemorrhage

Translational Neuroscience, 2023
Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5–7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH ...
Aycan Abdurrahman, Tas Abdurrahim, Yeltekin Asli Cilingir, El-Tekreti Sama Amer Abbas, Arslan Ayse, Arslan Mustafa, Aycan Nur   +6 more
doaj   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Human butyrylcholinesterase polymorphism: Molecular modeling

International Journal of Risk & Safety in Medicine, 2015
BACKGROUND: Prolonged apnoea following injection of ester-containing myoralaxants was first described in 1953. Because a large part of administered succinylcholine is shortly hydrolyzed by plasma butyrylcholinesterase (BChE) under normal conditions, prolonged apnoea was attributed to deficiency in BChE.
S, Lushchekina, H, Delacour, O, Lockridge, P, Masson   +3 more
openaire   +3 more sources

Benzoylcholine, Indole-3-acetic And Human Serum Butyrylcholinesterase Interactions [PDF]

Türk Biyokimya Dergisi, 2006
In this study we studied the kinetic interaction of indole-3- acetic acid with human serum butyrylcholinesterase. Butyrylcholinesterase was purified from human serum and the benzoylcholine kinetics was analyzed.
Ebru Bodur,, A. Neşe Çokuğraş
doaj  

Update on diagnosis, nonpharmacological treatment and prevention of Equine Gastric Ulcer Syndrome (EGUS)

Equine Veterinary Education, EarlyView.
Summary The term Equine Gastric Ulcer Syndrome (EGUS) has been used since 1999. As there are important differences, the terms Equine Squamous Gastric Disease (ESGD) and Equine Glandular Gastric Disease (EGGD) were introduced in 2015. Risk factors like dietary management, training regimens and drug side effects, as described for NSAIDs, predispose ...
R. Lensing, A. K. Barton
wiley   +1 more source

Signature Ions in MS/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine

Molecules, 2020
Bacterial transglutaminase was used to label human plasma proteins with fluorescent tags. Protein lysines were modified with dansyl-epsilon-aminohexyl-Gln-Gln-Ile-Val-OH (dansylQQIV), while protein glutamines were modified with dansyl cadaverine. Labeled
Lawrence M. Schopfer, Oksana Lockridge
doaj   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Emerging significance of butyrylcholinesterase

World Journal of Experimental Medicine
Butyrylcholinesterase (BChE; EC 3.1.1.8), an enzyme structurally related to acetylcholinesterase, is widely distributed in the human body. It plays a role in the detoxification of chemicals such as succinylcholine, a muscle relaxant used in anesthetic practice.
Sridhar, Gumpeny R, Gumpeny, Lakshmi
openaire   +2 more sources

Synthesis and biological evaluation of 3–(4-aminophenyl)-coumarin derivatives as potential anti-Alzheimer’s disease agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The work is focused on the design of drugs that prevent and treat Alzheimer’s disease (AD) and its complications. A series of 3–(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated in vitro/vivo.
Yu-Heng Hu, Jie Yang, Yun Zhang, Ke-Chun Liu, Teng Liu, Jie Sun, Xiao-Jing Wang   +6 more
doaj   +1 more source