Results 51 to 60 of about 11,286 (211)

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase [PDF]

, 2021
Jakub Jończyk, Jędrzej Kukułowicz, Kamil Łątka, Barbara Malawska, Young‐Sik Jung, Kamil Musílek, Marek Bajda   +6 more
openalex   +1 more source

Acute collapse in a dog with multiple autoimmune syndromes and polymyositis complicated by suspected organophosphate/carbamate toxicity

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 6.5‐year‐old, spayed, female dog presented in acute respiratory distress. On admission, the dog exhibited dyspnoea, bradycardia, cyanosis and gastrointestinal signs, requiring immediate intubation and mechanical ventilation. Diagnostic evaluation revealed reduced butyrylcholinesterase activity, non‐cardiogenic pulmonary oedema, elevated ...
Sarah Hefer, Efrat Kelmer, Michal Mazaki Tovi, Dana Peery, Kobi Aharoni, Nir Edry, Sigal Klainbart   +6 more
wiley   +1 more source

Synthesis, Structural Characterization, and Cholinesterase Inhibition of Sulfonamide Derivatives Incorporating Dipeptide Units

Journal of Chemistry
Five new sulfonamide deriatives bearing dipeptide moieties (4a-e) were synthesized and assessed for their inhibitory activity against acetylcholinesterase and butyrylcholinesterase. First, the condensation reaction of benzenesulfonyl chlorides (1a-c) and
Florence Uchenna Eze, Joshua Tochukwu Okoro, James Anayochukwu Ezugwu, Ogechi Chinelo Ekoh, Jeanet Conradie, David Izuchukwu Ugwu   +5 more
doaj   +1 more source

T1WI‐SWI Dual Modal Magnetic Resonance Nanoprobes for Accurate Diagnosis of Early Stage Alzheimer's Disease

Advanced Science, Volume 13, Issue 1, 5 January 2026.
We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li, Aijun Shen, Xiaolong Gao, Chao Lin, Zongliang Huang, Qi Lv, Junjun Tang, Xiaolong Ma, Jiong Ni, Ju Tian, Jiaqi Wu, Xiaowen Xu, Wei Wang, Peijun Wang   +13 more
wiley   +1 more source

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source

Structure–activity relationship, in vitro and in vivo evaluation of novel dienyl sulphonyl fluorides as selective BuChE inhibitors for the treatment of Alzheimer's disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
To discover novel scaffolds as leads against dementia, a series of δ-aryl-1,3-dienesulfonyl fluorides with α-halo, α-aryl and α-alkynyl were assayed for ChE inhibitory activity, in which compound A10 was identified as a selective BuChE inhibitor (IC50 ...
Chengyao Wu, Guijuan Zhang, Zai-Wei Zhang, Xia Jiang, Ziwen Zhang, Huanhuan Li, Hua-Li Qin, Wenjian Tang   +7 more
doaj   +1 more source

Exploring Adjunctive Novel Therapeutic Approach of KarXT (Xanomeline‐Trospium Chloride) for Managing Psychotic Symptoms in Patients With Schizophrenia and Alzheimer's Disease

Brain and Behavior, Volume 16, Issue 1, January 2026.
An overview of the mechanism of action, clinical trials, and classical findings of KarXT for the management of psychotic symptoms in patients with schizophrenia and alzheimer's disease. ABSTRACT Background Acute psychotic symptoms like delusions and hallucinations are of major concern while treating patients with schizophrenia and alzheimer's psychosis,
Ashir Kanwal, Bismah Azeem, Hania Nasir, Fatima Mumtaz, Nauman Ashraf, Mohammed Hammad Jaber Amin, Warisha Kanwal, Bilal Wazir Khan   +7 more
wiley   +1 more source

Sex‐Specific Response to Predator Auditory Cues in Asian Corn Borer (Ostrinia furnacalis)

Ecology and Evolution, Volume 16, Issue 1, January 2026.
Females downregulate more DEGs; males upregulate under predation risk. Males boost ecdysteroid; females reduce fecundity under bat ultrasound. Female O. furnacalis reacted more strongly to auditory cues of bats than males. ABSTRACT Predation risk has profound effects on prey from phenotype to gene expression.
Li Wang, Qiang Qu, Qiulin Guo, Junhao Guan, Jiayi Zhao, Yue Zhu, Tinglei Jiang, Jiang Feng, Hui Wu   +8 more
wiley   +1 more source

Bioactive Phenolic Compounds from Thapsia garganica L. Different Parts: HPLC‐DAD Profiling,Cholinesterase Inhibition, and Antioxidant Potential

ChemistrySelect, Volume 11, Issue 1, 8 January 2026.
ABSTRACT This study investigates the biological properties of methanolic and petroleum ether (PE) extracts from the roots and flowers of Thapsia garganica L., providing new insights into its potential medicinal uses. Although T. garganica has a long history in traditional medicine, the anticholinesterase and tyrosinase‐inhibiting activities of this ...
Rania Arabi, Meriem Chafaa, Dilaycan Çam, Cansel Çakir, Zohra Arabi, Leila Soudani, Mehmet Öztürk, Tarek H. Taha, Sulaiman A. Alsalamah, Takfarinas Idres, Stefania Garzoli, Hamdi Bendif   +11 more
wiley   +1 more source

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Molecules, 2017
Recent research shows that butyrylcholinesterase (BChE) is not simply a liver enzyme that detoxifies bioactive esters in food and medications. In fact, in pursuing other goals, we recently found that it has an equally important role in regulating the ...
Yang Gao, Liyi Geng, Vicky Ping Chen, Stephen Brimijoin   +3 more
doaj   +1 more source