Results 61 to 70 of about 11,286 (211)

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

Discovery of pyrrole derivatives as acetylcholinesterase-sparing butyrylcholinesterase inhibitor [PDF]

, 2022
Shouyuan Sun, Tao Shi, Yan Peng, Honghua Zhang, Linsheng Zhuo, Peng Xue, Qien Li, Manxia Wang, Shuzhi Wang, Zhen Wang   +9 more
openalex   +1 more source

Developing downstream processes for the purification of recombinant proteins and small molecules from Nicotiana benthamiana biomass

Plant Biotechnology Journal, Volume 24, Issue 1, Page 66-80, January 2026.
Summary Nicotiana benthamiana (Australian tobacco) has become a major host for plant‐based recombinant protein production, especially using transient expression. Once a candidate protein has been designed and produced in a suitable variety (e.g. facilitated humanized glycosylation) under reproducible conditions (e.g.
J. F. Buyel
wiley   +1 more source

Imaging butyrylcholinesterase activity in Alzheimer's disease [PDF]

Annals of Neurology, 2006
Brain-Mind Project and University of Miami School of Medicine, Miami, FL, Departments of Medicine, Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada, Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD, and Laboratory for Neurodegenerative and
Kuhl, David E., Koeppe, Robert A., Snyder, Scott E., Minoshima, Satoshi, Frey, Kirk A., Kilbourn, Michael R.   +5 more
openaire   +3 more sources

Occurrence of butyrylcholinesterase polymorphisms in patients undergoing surgery in Slovakia. [PDF]

, 2023
Lukáš Čuchráč, Marta Mydlárová Blaščáková, Jozef Firment, J Šimonová, Jarmila Bernasovská, Janka Vašková   +5 more
openalex   +1 more source

Licochalcone A as Novel Multitarget Inhibitors via AChE, BuChE, and Synapsin III for Therapeutic Intervention Against Alzheimer’s Disease: Computer‐Aided Drug Design

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Alzheimer’s disease (AD) is characterized by key pathological features, including cholinergic dysfunction, amyloid‐beta (Aβ) aggregation, and disrupted synaptic transmission, positioning proteins such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and Synapsin III as critical targets for therapeutic strategies.
Ali Alimari, Bagher Seyedalipour, Payam Baziyar, Ehsan Joz Jalalian, Sohini Basu Roy   +4 more
wiley   +1 more source

Butyrylcholinesterase and the cholinergic system

Neuroscience, 2013
The cholinergic system plays important roles in neurotransmission in both the peripheral and central nervous systems. The cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and its action terminated by acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).
Reid, G.A., Chilukuri, N., Darvesh, S.
openaire   +2 more sources

Gene Expression Omnibus database analysis reveals comorbidity mechanisms of type 2 diabetes mellitus and vascular dementia and predicts potential herbal therapeutics

Advanced Chinese Medicine, Volume 2, Issue 4, Page 147-162, December 2025.
Abstract Objective This study aimed to investigate the comorbid mechanisms linking type 2 diabetes mellitus (T2DM) and vascular dementia (VaD), focusing on the roles of astrocytes and neurons, and to identify potential therapeutic traditional Chinese medicines (TCMs) and compounds.
Meiyue Li, Xue Li, Lijia Xu, Peigen Xiao, Pei Ma, Lifeng Yue   +5 more
wiley   +1 more source

Triterpene-Based Carboxamides Act as Good Inhibitors of Butyrylcholinesterase

Molecules, 2019
A set of overall 40 carboxamides was prepared from five different natural occurring triterpenoids including oleanolic, ursolic, maslinic, betulinic, and platanic acid.
Anne Loesche, Michael Kahnt, Immo Serbian, Wolfgang Brandt, René Csuk   +4 more
doaj   +1 more source

Genome‐Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms–Fish Hosts System and Drug Target Identification

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang, Jie‐Mei Zhao, Chuan‐Yu Xiang, Yi‐Wen Ma, Hong‐Peng Lei, Yu‐Ying Shi, Shun Zhou, Xiaofei Zeng, Jinsong Chen, Fei Liu, Benhe Zeng, Rui Song, Ye Hu, Feng Zhang, Xiang Liu, Wen‐Xiang Li, Gui‐Tang Wang, Ivan Jakovlić   +17 more
wiley   +1 more source