Results 71 to 80 of about 11,286 (211)

Novel pyridazinone derivatives as butyrylcholinesterase inhibitors

Bioorganic Chemistry, 2019
In the current study, forty-four new [3-(2/3/4-methoxyphenyl)-6-oxopyridazin-1(6H)-yl]methyl carbamate derivatives were synthesized and evaluated for their ability to inhibit electric eel acetylcholinesterase (EeAChE) and equine butyrylcholinesterase (eqBuChE) enzymes.
Dundar, Yasemin, Kuyrukcu, Ozge, Eren, Gokcen, Deniz, F. Sezer Senol, Onkol, Tijen, Orhan, Ilkay Erdogan   +5 more
openaire   +4 more sources

Cholinergic Dysregulation in Alzheimer's Disease: A Meta‐Analysis of Enzymatic Activity and Regional Alterations in Brain and Cerebrospinal Fluid

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Alzheimer's disease (AD), the leading cause of dementia, is characterized by β‐amyloid plaques, tau tangles, and early cholinergic dysfunction. This meta analysis examines changes in Butyrylcholinesterase (BChE), Acetylcholinesterase (AChE), Choline Acetyltransferase (ChAT), and choline levels in brain regions and cerebrospinal ...
Muneeb Ahmad Muneer, Harshita Agarwal, Poorvikha Gowda, Mohammad Orooj Azmi, Parshant Yadav, Victor Ghosh, Mohammad Hassan, Anmol Kaur, Vinay Suresh, Ahmed Y. Azzam, Mainak Bardhan, Alzheimer's Interest and Analytics Group ‐ NeuroStats Network   +11 more
wiley   +1 more source

Butyrylcholinesterase Protein Ends in the Pathogenesis of Alzheimer’s Disease—Could BCHE Genotyping Be Helpful in Alzheimer’s Therapy?

Biomolecules, 2019
Late-onset Alzheimer’s disease (AD) is clinically characterized by a progressive decline of memory and other cognitive functions leading to the loss of the ability to perform everyday activities.
Jacek Jasiecki, Bartosz Wasąg
doaj   +1 more source

Automatable Flow System for Paraoxon Detection with an Embedded Screen-Printed Electrode Tailored with Butyrylcholinesterase and Prussian Blue Nanoparticles

Chemosensors, 2015
Nowadays extensive volumes of pesticides are employed for agricultural and environmental practices, but they have negative effects on human health. The levels of pesticides are necessarily restricted by international regulatory agencies, thus rapid ...
Fabiana Arduini, Daniela Neagu, Viviana Scognamiglio, Sabrina Patarino, Danila Moscone, Giuseppe Palleschi   +5 more
doaj   +1 more source

Secondary Structure of Butyrylcholinesterase

Journal of Diabetes & Metabolism, 2012
Objective: Butyrylcholinesterase, a protein from the esterase family of enzymes, has been shown to modulate the expression of insulin resistance syndrome. In order to identify related proteins with more well established functions, the current in silico work was done to delineate the secondary structure of the enzyme and compare it with other proteins ...
Srinivas K, Sridhar GR
openaire   +1 more source

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

Molecules, 2017
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission.
Terrone L. Rosenberry, Xavier Brazzolotto, Ian R. Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nachon   +6 more
doaj   +1 more source

Synthesis, Analysis, Cholinesterase-Inhibiting Activity and Molecular Modelling Studies of 3-(Dialkylamino)-2-hydroxypropyl 4-[(Alkoxy-carbonyl)amino]benzoates and Their Quaternary Ammonium Salts

Molecules, 2017
Tertiary amines 3-(dialkylamino)-2-hydroxypropyl 4-[(alkoxycarbonyl)amino]benzoates and their quaternary ammonium salts were synthesized. The final step of synthesis of quaternary ammonium salts was carried out by microwave-assisted synthesis.
Tereza Padrtova, Pavlina Marvanova, Klara Odehnalova, Renata Kubinova, Oscar Parravicini, Adriana Garro, Ricardo D. Enriz, Otakar Humpa, Michal Oravec, Petr Mokry   +9 more
doaj   +1 more source

Obesity and variants of the GHRL (ghrelin) and BCHE (butyrylcholinesterase) genes

Genetics and Molecular Biology, 2011
Ghrelin coded by the GHRL gene is related to weight-gain, its deactivation possibly depending on its hydrolyzation by butyrylcholinesterase (BChE) encoded by the BCHE gene, an enzyme already associated with the body mass index (BMI).
Vitor G.L. Dantas, Lupe Furtado-Alle, Ricardo L.R. Souza, Eleidi A. Chautard-Freire-Maia   +3 more
doaj   +1 more source

Butyrylcholinesterase as a biochemical marker

Bratislava Medical Journal, 2013
Butyrylcholinesterase (BChE) is an enzyme expressed in multiple organs and abundant in plasma. BChE can fluctuate in course of several reasons while both hypercholiensterasemia and hypocholinesterasemia are known. Considering evidence of BChE activity alterations, hepatocellular carcinoma, chronic liver diseases and poisoning with carbamates or ...
openaire   +3 more sources

Photography by Cameras Integrated in Smartphones as a Tool for Analytical Chemistry Represented by an Butyrylcholinesterase Activity Assay

Sensors, 2015
Smartphones are popular devices frequently equipped with sensitive sensors and great computational ability. Despite the widespread availability of smartphones, practical uses in analytical chemistry are limited, though some papers have proposed promising
Miroslav Pohanka
doaj   +1 more source